کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7623386 | 1494541 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lepisanthes alata (Malay cherry) leaves are potent inhibitors of starch hydrolases due to proanthocyanidins with high degree of polymerization
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Type-II diabetes has become a health threat globally. One major challenge for diabetes patients is to control their post-prandial hyperglycaemia, which could be achieved through the inhibition of α-amylase and α-glucosidase. Lepisanthes alata (Malay cherry) was discovered as a promising edible plant with high starch hydrolase inhibition activities for corn starch hydrolysis with IC50 of its aqueous extracts at 0.77â±â0.09âµg/mL (for porcine α-amylase) and 10.83â±â0.67âµg/mL (for rat intestinal α-glucosidase). Proanthocyanidins were identified to be responsible as active compounds. The proanthocyanidin exhibited high degree (mDP at 27) of polymerization and was composed of (epi)catechins and (epi)gallocatechins linked through B-type 4-8 interflavanyl bonds. Inhibition kinetic study revealed that the proanthocyanidins were a mixed noncompetitive inhibitor against α-amylase but competitive inhibitor against α-glucosidase. Our discovery highlighted the potential of the leaves of L. alata for use in prevention of post prandial hyperglycaemia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 25, August 2016, Pages 568-578
Journal: Journal of Functional Foods - Volume 25, August 2016, Pages 568-578
نویسندگان
Yan Zhang, Adeline Ik Chian Wong, Ji'en Wu, Nura Binte Abdul Karim, Dejian Huang,