Metabolism of palmatine by human hepatocytes and recombinant cytochromes P450

- New LC-MS method for analysis of palmatine and its metabolites was developed.
- Biotransformation of palmatine in human hepatocytes was examined for the first time.
- Phase I and phase II metabolites of palmatine were analyzed.
- CYP2D6 and to a lesser extent CYP1A2 metabolize palmatine in vitro.