Direct S-difluoromethylation of thiols using the Ruppert-Prakash reagent

- Direct S-difluoromethylation of aliphatic and aromatic thiols using TMSCF3.
- Selective S-difluoromethylation in presence of OH, NH2 and CO2H functional groups.
- One-pot nucleophilic (arylsulfanyl)difluoromethylation of PhCHO.
- Short reaction times and ambient temperatures.