Systematic study of the reactivity of (E)-4,4,4-trifluorobut-2-en-1-yl 4-methylbenzenesulfonate towards different classes of nucleophiles

- The reactivity of (E)-4,4,4-trifluorobut-2-en-1-yl 4-methylbenzenesulfonate towards different nucleophiles was performed.
- Phenol, amines, thiols, and malonates all provide the substitution product in moderate to excellent yields.
- Benzyl alcohol and indole provide low yield of the desired product.