کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7796591 | 1501066 | 2018 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects on tubulin polymerization and down-regulation of c-Myc, hTERT and VEGF genes by colchicine haloacetyl and haloaroyl derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Several N-acyl colchicine analogues have been synthesized and their cytotoxicity, their effects on inhibition of tubulin polymerization and cell cycle have been evaluated. Moreover their capacity to downregulate some oncogenes at nontoxic dosis have been evaluated. The haloaroyl moiety enhances oncogene down-regulation effect as regards colchicine itself. Outstanding results for m-chlorobenzoylderivative 14 were obtained as this derivative is able to decrease the expression of oncogenes involved in tumor aggressiveness at concentrations in which there is no antimitotic effect.374
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 150, 25 April 2018, Pages 591-600
Journal: European Journal of Medicinal Chemistry - Volume 150, 25 April 2018, Pages 591-600
نویسندگان
Ana Marzo-Mas, Eva Falomir, Juan Murga, Miguel Carda, J. Alberto Marco,