کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7796591 1501066 2018 44 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects on tubulin polymerization and down-regulation of c-Myc, hTERT and VEGF genes by colchicine haloacetyl and haloaroyl derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Effects on tubulin polymerization and down-regulation of c-Myc, hTERT and VEGF genes by colchicine haloacetyl and haloaroyl derivatives
چکیده انگلیسی
Several N-acyl colchicine analogues have been synthesized and their cytotoxicity, their effects on inhibition of tubulin polymerization and cell cycle have been evaluated. Moreover their capacity to downregulate some oncogenes at nontoxic dosis have been evaluated. The haloaroyl moiety enhances oncogene down-regulation effect as regards colchicine itself. Outstanding results for m-chlorobenzoylderivative 14 were obtained as this derivative is able to decrease the expression of oncogenes involved in tumor aggressiveness at concentrations in which there is no antimitotic effect.374
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 150, 25 April 2018, Pages 591-600
نویسندگان
, , , , ,