Tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one scaffold derivatives: Synthesis and biological evaluation as selective BuChE inhibitors

Novel tricyclic scaffolds were discovered as selective BuChE inhibitors. Compounds 3f and 3o with dihalogen and a 6-ethyl substituent exhibited the most potent activity. Compound 3o showed remarkable neuroprotective activity.270