کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7803259 1501176 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents
چکیده انگلیسی
► 13 new heterobivalent tacrine derivatives as multi-functional anti-Alzheimer agents were synthesized. ► Compounds showed high inhibitory activities for AChE and BuChE. ► Compounds interacted at both catalytic active site and peripheral anionic site of AChE. ► Some of these compounds exhibited potent antioxidation activity and inhibition of self-induced Aβ aggregation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 6, June 2011, Pages 2609-2616
نویسندگان
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