Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents

► 13 new heterobivalent tacrine derivatives as multi-functional anti-Alzheimer agents were synthesized. ► Compounds showed high inhibitory activities for AChE and BuChE. ► Compounds interacted at both catalytic active site and peripheral anionic site of AChE. ► Some of these compounds exhibited potent antioxidation activity and inhibition of self-induced Aβ aggregation.