کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8148428 | 1524332 | 2018 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A new polymorph of fenofibrate prepared by polymer-mediated crystallization
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The polymer-mediated crystallization is an effective means to control the drug crystal. This project was focusing on a new form of Fenofibrate (Form IV) obtained by polymer-mediated crystallization. Medical polymer materials such as Hydroxy Propyl Methyl Cellulose (HPMC), Sodium Carboxyl Methyl Cellulose (CMC-Na) and Polyvinylpyrrolidone (PVP) were tested in this study. The powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA) and Fourier Transform Infrared Spectroscopy (FTIR) were used to differentiate the new form and other known forms. Material studio was applied to solve structures of Form IV. These polymorphic forms present different physicochemical properties. The crystallization conditions of Form IV were also detected. The study disclosed the Form IV has a low melting point of 65â¯Â°C and it is more stable compared with other metastable forms. This new form was proved to be more soluble in 0.5% tween-80 solution, which suggested it has highly potential to generate medicinal crystal.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Crystal Growth - Volume 498, 15 September 2018, Pages 93-102
Journal: Journal of Crystal Growth - Volume 498, 15 September 2018, Pages 93-102
نویسندگان
Xiangjun Shi, Yinghua Shao, Xiaoxia Sheng,