Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation

The legend is as follows: Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation. Reactive oxygen species are generated and then participate in osteoclast differentiation. Nrf2 deficiency leads to the promotion of RANKL-induced osteoclast differentiation, most likely owing to a higher level of oxidative stress that is caused by the aberrant production of antioxidant enzymes and GSH.131