کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8351156 | 1541860 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nicotine enhances the expression of a sucrose or cocaine conditioned place preference in adult male rats
ترجمه فارسی عنوان
نیکوتین باعث افزایش ترشح محل مکمل سقز یا کوکائین در موش صحرایی نر است
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کلمات کلیدی
کوکائین، ترجیح محل مواجه، ارتقاء، نیکوتین، تقویت، ساکارز،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Nicotine has been shown to enhance the motivational properties of non-nicotine stimuli. This reinforcement-enhancing property of nicotine has the potential to promote the use of other illicit substances as well as maladaptive patterns of food intake. Therefore, the current study aimed to examine whether nicotine enhances preference for contexts paired with cocaine or sucrose utilizing a place conditioning procedure. Separate groups of adult male rats were administered sucrose or cocaine in one of two compartments of a standard CPP chamber on four consecutive days. Preference was then assessed following no injection, a single subcutaneous (s.c.) injection of nicotine, and a s.c. saline injection. The animals preferred the chamber paired with either sucrose or cocaine, as evident from an increased time spent in the paired chamber compared to baseline. Nicotine further increased the time spent in the sucrose- or cocaine-paired chamber, consistent with a reinforcement-enhancement effect. Previous results demonstrate an interaction between nicotine and intake of other drugs or food. The present findings provide an additional mechanism that may underlie these effects and which may have implications for drug dependence and obesity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 124, September 2014, Pages 320-325
Journal: Pharmacology Biochemistry and Behavior - Volume 124, September 2014, Pages 320-325
نویسندگان
Deanne M. Buffalari, Nana Yaa A. Marfo, Tracy T. Smith, Melissa E. Levin, Matthew T. Weaver, Edda Thiels, Alan F. Sved, Eric C. Donny,