کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8384008 1543461 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Commitment of Annexin A2 in recruitment of microRNAs into extracellular vesicles
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Commitment of Annexin A2 in recruitment of microRNAs into extracellular vesicles
چکیده انگلیسی
Extracellular vesicles (EVs) contain microRNAs (miRNAs). However, the exact molecular mechanisms of the recruitment of miRNAs in EVs are not well characterized. Based on proteomic analysis, we identified that silencing of Annexin A2 (ANXA2) significantly decreased the amount of miRNAs in EVs. In addition, microarray analysis revealed that ANXA2 regulated the loading of miRNAs into EVs in a sequence independent manner. Lastly, immunoprecipitation analysis confirmed that ANXA2 could bind miRNAs in EVs in the presence of Ca2+. These observations demonstrate that ANXA2 plays an important role in the packaging process of miRNAs into EVs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 24, Part B, 21 December 2015, Pages 4071-4078
نویسندگان
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