کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8460243 | 1548976 | 2018 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Salivary biomarkers of inflammation in systemic lupus erythematosus
ترجمه فارسی عنوان
بیومارکرهای بزاق از التهاب در لوپوس اریتماتیک سیستمیک
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کلمات کلیدی
بزاق، بیومارکر، اینترلوکین -6، لپتین، لوپوس اریتماتوی سیستمیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Saliva is currently used as a reliable diagnostic fluid in a wide range of local and systemic diseases. However, the link between salivary diagnosis and the inflammatory process in autoimmune diseases has not yet been explored. The aim of our study is to assess possible correlations between salivary inflammatory markers and systemic lupus erythematosus (SLE). Patients fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) diagnosis criteria were included. Salivary and serum levels of interleukin-6 (IL-6), leptin, monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) were determined using stochastic sensors. Serum leptin and IL-6 had significantly higher levels in SLE patients compared to non-SLE. Also, salivary IL-6 levels highly correlated with the serum IL-6 levels. A positive correlation was found between salivary and serum levels of IL-6, signaling salivary IL-6 as a reliable marker for assessing the inflammation process in SLE.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Anatomy - Anatomischer Anzeiger - Volume 219, September 2018, Pages 89-93
Journal: Annals of Anatomy - Anatomischer Anzeiger - Volume 219, September 2018, Pages 89-93
نویسندگان
Iulia-Ioana Stanescu, Bogdan Calenic, Alina Dima, Livia Alexandra Gugoasa, Eugenia Balanescu, Raluca-Ioana Stefan-van Staden, Cristian Baicus, Daniela Gabriela Badita, Maria Greabu,