کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8477742 1550925 2011 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of expression and structure of the rat GH-secretagogue/ghrelin receptor (Ghsr) gene: Roles of epigenetic modifications in transcriptional regulation
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Analysis of expression and structure of the rat GH-secretagogue/ghrelin receptor (Ghsr) gene: Roles of epigenetic modifications in transcriptional regulation
چکیده انگلیسی
► The molecular basis for tissue and cell type-specific expression of GHSR has not yet been fully elucidated. ► The 5′-flanking region of the rat Ghsr gene was structurally and functionally characterized. ► The minimal promoter region was mapped to a region 200-bp upstream from the novel 5′-untranslated first exon. ► DNA methylation and histone modifications at the Ghsr proximal promoter were highly correlated with mRNA expressions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 345, Issues 1–2, 15 October 2011, Pages 1-15
نویسندگان
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