کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8516338 | 1556575 | 2018 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Group I metabotropic glutamate receptors generate two types of intrinsic membrane oscillations in hippocampal oriens/alveus interneurons
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کلمات کلیدی
HEPES(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acidLY 3673852-aminoethoxydiphenylborateCGP55845SR95531ACPD2-APBMPEPNBQXmGluRAPVN-methyl-d-aspartateDHPGDICFFAAMPAaCSFNMDATTX(S)-3,5-dihydroxyphenylglycine - (S) -3،5-دی هیدروکسی فنیل گلیسین1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid - 1،2-bis (2-aminophenoxy) ethane-N، N، N '، N'-tetraacetic acid2-methyl-6-(phenylethynyl)pyridine hydrochloride - 2- متیل-6- (فنیل اتیینیل) پیریدین هیدروکلراید2-amino-5-phosphonopentanoic acid - 2-آمینو-5-فسفونوپنتانوئیک اسید4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid - 4- (2-hydroxyethyl) -1-piperazineethanesulfonic acidα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid - اسید α-آمینو 3-هیدروکسی-5-متیل-4-ایزوکسول پپونیکflufenamic acid - اسید فلوفنامیکexcitotoxicity - اکسید سمیتBAPTA - بیایپیتیایtetrodotoxin - تترو دوتوکسین Seizures - تشنجartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیaction potential - پتانسیل عمل TRP channels - کانال های TRPdifferential interference contrast - کنتراست تداخل دیفرانسیلMetabotropic glutamate receptors - گیرنده های متابوتروپیک گلوتاماتMetabotropic glutamate receptor - گیرنده گلوتامات متابوتروپیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
GABAergic interneurons in the hippocampus are critically involved in almost all hippocampal circuit functions including coordinated network activity. Somatostatin-expressing oriens-lacunosum moleculare (O-LM) interneurons are a major subtype of dendritically projecting interneurons in hippocampal subregions (e.g., CA1), and express group I metabotropic glutamate receptors (mGluRs), specifically mGluR1 and mGluR5. Group I mGluRs are thought to regulate hippocampal circuit functions partially through GABAergic interneurons. Previous studies suggest that a group I/II mGluR agonist produces slow supra-threshold membrane oscillations (<0.1â¯Hz), which are associated with high-frequency action potential (AP) discharges in O-LM interneurons. However, the properties and underlying mechanisms of these slow oscillations remain largely unknown. We performed whole-cell patch-clamp recordings from mouse interneurons in the stratum oriens/alveus (O/A interneurons) including CA1 O-LM interneurons. Our study revealed that the selective mGluR1/5 agonist (S)-3,5-dihydroxyphenylglycine (DHPG) induced slow membrane oscillations (<0.1â¯Hz), which were associated with gamma frequency APs followed by AP-free perithreshold gamma oscillations. The selective mGluR1 antagonist (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid (LY367385) reduced the slow oscillations, and the selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine hydrochloride (MPEP) partially blocked them. Blockade of nonselective cation-conducting transient receptor potential channels, L-type Ca2+ channels, or ryanodine receptors all abolished the slow oscillations, suggesting the involvement of multiple mechanisms. Our findings suggest that group I mGluR activation in O/A interneurons may play an important role in coordinated network activity, and O/A interneuron vulnerability to excitotoxicity, in disease states like seizures, is at least in part due to an excessive rise in intracellular Ca2+.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 139, 1 September 2018, Pages 150-162
Journal: Neuropharmacology - Volume 139, 1 September 2018, Pages 150-162
نویسندگان
Gubbi Govindaiah, Young-Jin Kang, Hannah Elisabeth Smashey Lewis, Leeyup Chung, Ethan M. Clement, Lazar John Jr., Edgar Garcia-Rill, Sang-Hun Lee,