کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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877470 | 911029 | 2014 | 10 صفحه PDF | دانلود رایگان |
So far, we still know little about mechanism for recovery response of engineered nanomaterials (ENMs). Here we used Caenorhabditis elegans to investigate recovery responses of titanium dioxide nanoparticles (TiO2-NPs) exposed animals and the underlying mechanism. After acute exposure to TiO2-NPs (100 mg/L), endpoints including defecation and permeable state of intestinal barrier of exposed nematodes returned to control levels; however, after prolonged exposure to TiO2-NPs (100 μg/L), endpoints of exposed nematodes could not be recovered to control levels under the normal condition. After prolonged exposure to TiO2-NPs, nematodes exhibited severe deficits in development of intestinal barrier and AVL and DVB neurons controlling defecation; however, after acute exposure to TiO2-NPs, nematodes had normal developmental state of intestinal barrier and AVL and DVB neurons. Our results imply that developmental states of intestinal barrier and AVL and DVB neurons may serve as a pivotal determinant for recovery response in TiO2-NPs exposed nematodes.From the Clinical EditorThis basic science study investigates the recovery response to TiO2 nanoparticles in a nematode model, and concludes that developmental states of the intestinal barrier and AVL and DVB neurons likely serve as determinants for recovery following TiO2-NP exposure.
Graphic AbstractIn C. elegans, after prolonged exposure to high concentrations of TiO2-NPs, animals may meet difficulties to exhibit the recovery response under the normal condition. We raised a hypothesis that both defecation behavior and intestinal barrier contribute greatly to the recovery response formation for TiO2-NPs exposed animals. Structural state of both neurons controlling defecation behavior and intestinal barrier may play a pivotal role in regulating the recovery response formation in TiO2-NPs exposed animals under the normal condition.Figure optionsDownload high-quality image (158 K)Download as PowerPoint slide
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 10, Issue 1, January 2014, Pages 89–98