Number of Hyperreflective Foci in the Outer Retina Correlates with Inflammation and Photoreceptor Degeneration in Retinitis Pigmentosa

Outer retinal HRF number is associated with intraocular inflammation and photoreceptor degeneration in RP. Their distribution in areas with IS/OS disruption and low autofluorescence suggests that outer retinal HRF reflect defects in the retinal pigment epithelium (RPE) layer caused by RPE cell or microglial migration in response to photoreceptor degeneration.