کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9017853 | 1128671 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lipid peroxidation induced by carbon tetrachloride and its inhibition by antioxidant as evaluated by an oxidative stress marker, HODE
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کلمات کلیدی
PBSBO-653HpODEGPT8-iso-PGF2α - 8-ISO-PGF2α8-iso-prostaglandin F2α - 8-ایزو پروستاگلاندین F2αHODE - HEADN,O-bis(trimethylsilyl)trifluoroacetamide - N، O-bis (trimethylsilyl) trifluoroacetamideAntioxidant - آنتی اکسیدانhydroperoxyoctadecadienoic acid - اسید هیدروپروئیکوکتا داکدینوئیکhydroxyoctadecadienoic acid - اسید هیدروکسیکوکاتدکادویوئیکIsoprostanes - ایزوپروتامین هاGOT - بدست آوردglutamic oxaloacetic transaminase - ترانس آمیناز اگزوالکتیک گلوتامیکglutamic pyruvic transaminase - ترانس آمیناز پریوویک گلوتامینTocotrienol - توکوتیرنولTocopherol - توکوفرولPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریLipid peroxidation - پراکسیداسیون لیپیدCarbon tetrachloride - کربن تتراکلرید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We have recently proposed total hydroxyoctadecadienoic acid (HODE) as a biomarker for oxidative stress in vivo. The biological samples such as plasma, urine, and tissues were first reduced and then saponified to convert the oxidation products of linoleate to HODE. In the present study, this method was applied to measure the oxidative damage induced by the administration of carbon tetrachloride to mice and also to evaluate the capacity of antioxidant to inhibit the above damage. α-Tocopherol transfer protein knock out (α-TTPâ/â) mice were used to evaluate antioxidant effect in the absence of α-tocopherol. The intraperitoneal administration of carbon tetrachloride to mice induced the increase in HODE in liver and plasma, which was followed by an increase in plasma glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT). F2-isoprostanes, another prevailing biomarker, were also increased similarly, but their concentration was approximately two to three orders of magnitude smaller than that of HODE. The lipophilic antioxidants such as γ-tocopherol, γ-tocotrienol and 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran (BO-653) were effective in suppressing the formation of HODE.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 208, Issue 1, 1 October 2005, Pages 87-97
Journal: Toxicology and Applied Pharmacology - Volume 208, Issue 1, 1 October 2005, Pages 87-97
نویسندگان
Yasukazu Yoshida, Nanako Itoh, Mieko Hayakawa, Rosaria Piga, Osamu Cynshi, Kou-ichi Jishage, Etsuo Niki,