کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425412 | 1295869 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hippocalcin-deficient mice display a defect in cAMP response element-binding protein activation associated with impaired spatial and associative memory
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کلمات کلیدی
VGCCNCSPFAaCSFNMDAN-methyl-d-aspartatefEPSPmGluRMK801APVGRKNVPMCPGMLKG-protein coupled receptor kinasemitogen activating proteinVILIPPDECREBPLDPBSPPFPSD+/+ - + / +−/− - - / -2-amino-5-phosphonopentanoic acid - 2-آمینو-5-فسفونوپنتانوئیک اسیدcAMP - cAMPNMDA receptor - NMDA گیرندهCyclic adenosine monophosphate - آدنوزین مونوفسفات Cycliclong-term depression - افسردگی طولانی مدتanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancepostsynaptic density - تراکم Postinapticpaired-pulse facilitation - تسکین زوایای پالسیlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP SMA - دبیرستانlight-emitting diode - دیود نورافشانLED - رهبریembryonic stem - ساقه جنینneuronal calcium sensor - سنسور کلسیم نورونPhosphodiesterase - فسفو دی استرازPhospholipase D - فسفولیپاز DSpontaneous motor activity - فعالیت حرکتی خود به خودیimmediate-early - فورا اوایلknockout mouse - ماوس نابود شدهartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیLTD - محدودPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریmap - نقشهwild-type - نوع وحشیHippocalcin - هیپوکالسینpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازparaformaldehyde - پارافرمالدهیدField excitatory postsynaptic potential - پتانسیل پستنیپتیک مزمن تحریک پذیرcAMP response element-binding protein - پروتئین واکنش القا کننده واکنش cAMPVoltage-gated Ca2+ channel - کانال Ca2 + با ولتاژmixed lineage kinase - کیناز قارچ مخلوطMetabotropic glutamate receptor - گیرنده گلوتامات متابوتروپیکVisual discrimination learning - یادگیری تبعیض بصریSpatial learning - یادگیری فضایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hippocalcin is a member of the neuronal calcium sensor (NCS) protein family that is highly expressed in hippocampal pyramidal cells and moderately expressed in the neurons of cerebral cortex, cerebellum and striatum. Here we examined the physiological roles of hippocalcin using targeted gene disruption. Hippocalcin-deficient (â/â) mice displayed no obvious structural abnormalities in the brain including hippocampal formation at the light microscopic level. Deletion of hippocalcin did not result in up-regulation of the hippocalcin-related proteins; neural visinin-like Ca2+-binding proteins (NVP) 1, 2, and 3. The synaptic excitability of hippocampal CA1 neurons appeared to be normal, as estimated by the shape of field excitatory postsynaptic potentials elicited by single- and paired-pulse stimuli, and by tetanic stimulation. However, N-methyl-d-aspartate stimulation- and depolarization-induced phosphorylation of cAMP-response element-binding protein (CREB) was significantly attenuated in â/â hippocampal neurons, suggesting an impairment in an activity-dependent gene expression cascade. In the Morris water maze test, the performance of â/â mice was comparable to that of wild-type littermates except in the probe test, where â/â mice crossed the previous location of the platform significantly less often than +/+ mice. Hippocalcin-deficient mice were also impaired on a discrimination learning task in which they needed to respond to a lamp illuminated on the left or right side to obtain food reinforcement. No abnormalities were observed in motor activity, anxiety behavior, or fear learning. These results suggest that hippocalcin plays a crucial role in the Ca2+-signaling pathway that underlies long-lasting neural plasticity and that leads to spatial and associative memory.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 133, Issue 2, 2005, Pages 471-484
Journal: Neuroscience - Volume 133, Issue 2, 2005, Pages 471-484
نویسندگان
M. Kobayashi, T. Masaki, K. Hori, Y. Masuo, M. Miyamoto, H. Tsubokawa, H. Noguchi, M. Nomura, K. Takamatsu,