کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
9569522 1666336 2019 6 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Interaction of tetramer protein with carbon nanotubes
ترجمه فارسی عنوان
تعامل پروتئین تترامر با نانولوله های کربنی
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
چکیده انگلیسی
Carbon nanotubes can interact with proteins or enzymes upon penetration into cell membranes of living organisms that may affect the protein-protein interactions in vivo. Here, three structural models composed of four-chain esterase from Hungatella hathewayi with and without pristine or carboxylated single-walled carbon nanotube (SWCNT) are constructed to investigate the changes in protein-protein interactions and SWCNT orientations by molecular dynamics simulations. The results show that the protein-protein interact very tightly to protect them from the separation by the carboxylated or pristine SWCNTs, as shown by the calculations of binding affinity and the distances between the centers of mass of different protein chains. Both pristine and carboxylated SWCNTs cause structural changes in the esterase. In addition, functionalization (e.g., carboxylation) can regulate the SWCNT orientation when positioned near the esterase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Surface Science - Volume 464, 15 January 2019, Pages 30-35
نویسندگان
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