کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
977086 | 933170 | 2009 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Information propagation from IP3 to target protein: A combined model for encoding and decoding of Ca2+ signal
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
فیزیک ریاضی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
It is well known that information is encoded in the frequency or amplitude of Ca2+ signal and then decoded by target protein. However, few models considered both the encoding and decoding procedures of Ca2+ signal. In this work, a minimal Li-Rinzel model is coupled with a phosphorylation-dephosphorylation cycle model, which is used to investigate information transmissions from inositol 1,4,5-trisphosphate (IP3) to target proteins and their relations. We found that the mean target protein activity increases with the IP3 concentration, and at a low level of stimulation, the target protein can be more efficiently activated by an oscillatory signal than a constant signal of the same average calcium if Ca2+ acts cooperatively on the kinase. The internal noise resulting from the finite system size is also taken into account in the combined model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 388, Issue 19, 1 October 2009, Pages 4105-4114
Journal: Physica A: Statistical Mechanics and its Applications - Volume 388, Issue 19, 1 October 2009, Pages 4105-4114
نویسندگان
Qi Zhao, Ming Yi, Kelin Xia, Meng Zhan,