Keywords: Probabilistic prediction approaches; GEFS; Wind day; Heavy events prediction;
مقالات ISI (ترجمه نشده)
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Keywords: OS; overall survival; MAPK; mitogen-activated protein kinase; RTKs; receptor tyrosine kinases; PI3K; phosphatidylinositide 3-kinases; GEFs; guanine nucleotide exchange factors; GAPs; GTPase-activating proteins; FTIs; farnesyltransferase inhibitors; mTOR;
The experiences of a biochemist in the evolving world of G protein-dependent signaling
Keywords: Signaling; G-proteins; GPCRs; Ras; Cdc42; GAPs; GEFs;
IL-21 alleviates allergic asthma in DOCK8-knockout mice
Keywords: DOCK8 gene; Allergic asthma; Ovalbumin; Murine model; IL-21; rmIL-21; recombinant mouse interleukin-21; DOCK8; dedicator of cytokinesis 8; STAT3; signal transducer and activator of transcription 3; TYK2; tyrosine kinase 2; DIDS; DOCK8 immunodeficiency syn
KRAS-Mutant non-small cell lung cancer: From biology to therapy
Keywords: BATTLE; Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination; BET; bromodomains and extra-terminal domain; CDK; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CI; confidence interval; CUSTOM; Molecular Profiling and Targete
Tiam1/Vav2-Rac1 axis: A tug-of-war between islet function and dysfunction
Keywords: HG; high glucose; GEFs; guanine nucleotide exchange factors; GSIS; glucose-stimulated insulin secretion; NOD mice; nonobese diabetic mice; Nox2; phagocyte-like NADPH oxidase; Rac1; Ras-related C3 botulinum toxin substrate 1; ROS; reactive oxygen species;
Directional Migration in Esophageal Squamous Cell Carcinoma (ESCC) is Epigenetically Regulated by SET Nuclear Oncogene, a Member of the Inhibitor of Histone Acetyltransferase Complex
Keywords: ESCC; Esophageal squamous cell carcinoma; SET; SET nuclear oncogene; GEFs; Guanine nucleotide exchange factors; INHAT; Inhibitor of acetyltransferases; NAT; Natural antisense transcript;
Nudix-type motif 2 contributes to cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of rapamycin complex 1 localization
Keywords: mTORC1; mammalian target of rapamycin complex 1; NUDT2; Nudix-type motif 2; GEFs; guanine nucleotide exchange factors; GAPs; GTPase-activating proteins; Ap4A; 5â², 5â³-p1,p4-tetraphosphate; DCIS; ductal cell in situ; IDC; invasive ductal carcinoma cell;
Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP
Keywords: BCl3; boron trichloride; CAN; ceric ammonium nitrate; DAG; diacylglycerol; DBU; 1,8-diazabicyclo[5.4.0]undec-7-ene; DMAP; 4-dimethylaminopyridine; GEFs; guanine nucleotide exchange factors; LiHMDS; lithium hexamethyldisilazide; MRCKs; myotonic dystrophy k
A multi-scale ensemble-based framework for forecasting compound coastal-riverine flooding: The Hackensack-Passaic watershed and Newark Bay
Keywords: Coastal urban estuary; Ensembles; sECOM; HEC-RAS 2-D; GEFS; Uncertainty; Flood forecasting; Hydrodynamic modeling;
Redox regulation of the actin cytoskeleton and its role in the vascular system
Keywords: α; alpha; β; beta; γ; gamma; G-actin; globular actin; F-actin; filamentous actin; ROS; reactive oxygen species; O2â¢â; superoxide; H2O2; hydrogen peroxide; HOâ¢; hydroxyl radical; RNS; reactive nitrogen species; NO; nitric oxide; â¢NO2; nitrogen d
Intrinsic protein fluorescence assays for GEF, GAP and post-translational modifications of small GTPases
Keywords: GTPases; GEFs; GAPs; AnkX; Enzyme kinetics; Intrinsic protein fluorescence; DrrA/SidM; defect in Rab recruitment A, substrate of ICM/Dot transporter M; AnkX; Ankyrin repeat-containing protein X Phosphocholine transferase; Lem3; phosphocholine hydrolase; S
Crocetin ester improves myocardial ischemia via Rho/ROCK/NF-κB pathway
Keywords: AMI; acute myocardial ischemia; CE; crocetin ester; GEFs; guanine nucleotide exchanging factors; GAP; GTPase activating protein; GDI; GDP dissociation inhibitor; Pro; propranolol; ISO; isoproterenol; Crocetin ester; Myocardial ischemia; Rho; NF-κB;
Cell type-specific roles of RAS-MAPK signaling in learning and memory: Implications in neurodevelopmental disorders
Keywords: CFC; cardio-facio-cutaneous; CS; Costello syndrome; FACS; fluorescence-activated cell sorting; GAPs; GTPase activating proteins; GEFs; guanine nucleotide exchange factors; GFP; green fluorescent protein; HCN; hyperpolarization-activated cyclic nucleotide-
SUMOylation of RhoGDIα is required for its repression of cyclin D1 expression and anchorage-independent growth of cancer cells
Keywords: RhoGDIα; SUMOylation; Cyclin D1; Growth arrest; Anchorage-independent growth; CDK; cyclin-dependent kinase; Erk; extracellular stimuli mitogen-activated protein kinase; GDIs; GDP-dissociation inhibitors; GEFs; guanine nucleotide exchanging factors; GTP;
Crystal structure of GTPase-activating domain from human MgcRacGAP
Keywords: MgcRacGAP; male germ cell RacGap; MKLP1; mitotic kinesin-like protein 1; GAPs; GTPase-activating proteins; GEFs; guanine nucleotide exchange factors; GST; glutathione S-transferase; TEV; tobacco etch virus; IPTG; isopropyl-β-d-1-thiogalactopyranoside; PM
Kinetics of extracellular ATP in mastoparan 7-activated human erythrocytes
Keywords: ATPe; extracellular ATP; ATPi; intracellular ATP; CBX; carbenoxolone; CTZ; cilostazol; GEFs; guanine exchange factors; JR; flux of ATP release; JV; flux of ATPe hydrolysis; MST; mastoparan; PBC; probenecid; pnx; pannexin 1; pnx+/+; pannexin 1 wild type mi
Selective interactions of spinophilin with the C-terminal domains of the δ- and μ-opioid receptors and G proteins differentially modulate opioid receptor signaling
Keywords: GPCR; G protein-coupled receptors; RGS; Regulators of G protein Signaling; ÎÎRGS4; RGS4 lacking its N-terminal domain; 6xHis; hexahistidine; aa; amino acids; GEFs; Guanine nucleotide exchange factors; AC; adenylyl cyclase; DAMGO; [D-Ala2,N-MePhe4,Gly5-o
The RasGrf family of mammalian guanine nucleotide exchange factors
Keywords: GEFs; guanine nucleotide exchange factors; NMDA; N-methyl-d-aspartate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; CNS; Central Nervous System; DMD; differentially methylated domain; CTCF; CCCTC-binding protein; CDB; cyclin destruction b
Febrile seizures and temporal lobe epileptogenesis
Keywords: AMPA; α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate; FS; febrile seizures; GABA; γ-aminobutyric acid; GEFS; generalizes epilepsy and febrile seizures; HCN; hyperpolarization-activated cyclic-nucleotide gated channels; HS; hyperthermia-induced seizu
Prostaglandins PGE2 and PGI2 promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation
Keywords: Permeability; Lung endothelium; Small GTPases; Cytoskeleton; PKA; GEFs
Rolipram, salbutamol and prostaglandin E2 suppress TNFα release from human monocytes by activating Type II cAMP-dependent protein kinase
Keywords: Monocyte; TNFα; cAMP-dependent protein kinase; cAMP-GEF; GEFs; guanine nucleotide-exchange factors;
Ca2+ sensitization and the regulation of contractility in rat anococcygeus and retractor penis muscle
Keywords: CCh; carbachol; EFS; electrical field stimulation; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GEFs; guanine nucleotide exchange factors; GPCR; G protein coupled-receptor; HA-1077; (5-isoquinolinesulfonyl)homopiperazine; H-1152; (S)-(+)-2-methyl-1-[(
E3B1, a human homologue of the mouse gene product Abi-1, sensitizes activation of Rap1 in response to epidermal growth factor
Keywords: Abi-1; Abl-interactor-1; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GAP; GTPase-activating protein; GEFs; guanine nucleotide exchange factors; GST; glutathione-S-transferase; mAb; monoclonal antibody; pAb; polyclonal antibody; P