Keywords: Biomarker; Brain tumor; Diagnosis; Meningioma; Molecular characterization; Prognosis; Recurrence; AKT1; v-Akt murine thymoma viral oncogene homolog 1; BAP1; BRCA1-associated protein 1; CDKN2A and B; Cyclin-dependent kinase inhibitor 2A and 2B; FAK; Focal
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Keywords: saphenous vein; coronary artery bypass grafting; anatomy; patency; CABG; coronary artery bypass graft surgery; ITA; internal thoracic artery; KLF4; Krüppel-like factor 4; LLV; lower leg vein; SMD; standardized mean difference; SRF; serum response factor;
Keywords: As(III); arsenite; As(V); arsenate; MMA; monomethylarsonic acid; Nox 2; NADPH oxidase; NOS; nitric oxide synthases; ETC; electron transport chain; WAT; white adipose tissue; BAT; brown adipose Tissue; UCP; uncoupling protein; α-KDGH; α-ketoglutarate deh
Keywords: Primary cilia; KLF4; Osteoblasts; Hedgehog; SXR/PXR/Nr1i2;
Keywords: 5-FU; 5-Fluorouracil; ABCB5; ATP-binding cassette sub-family B member 5; ABCC2; ATP-binding cassette sub-family C member 2; ABCG2; ATP-binding cassette sub-family G member 2; ACs; Anthocyanins; ALDH; aldehyde dehydrogenase; AML; acute myeloid leukemia; AP
Keywords: 5-HT; serotonin (5-hydroxytryptamine); A83-01; TGF-β kinase/activin receptor-like kinase inhibitor; ACTB; actin beta/beta-actin; ASCL1; achaete-scute homolog 1 (MASH1); ASOs; anti-sense oligonucleotides; Bcl-xL; b-cell lymphoma-extra large; BDNF; brain d
Use of potential dietary phytochemicals to target miRNA: Promising option for breast cancer prevention and treatment?
Keywords: ALDH1; aldehyde dehydrogenase 1; AKT; protein kinase B; ARID4B; AT-rich interactive domain-containing protein 4B; BMI1; B-lymphoma Moloney murine leukemia virus insertion region-1; BMP1; bone morphogenetic protein 1; BRCA1; breast cancer 1; BIRC6; baculov
Keywords: 6-OHDA; 6-hydroxydopamine; Aβ; amyloid-β; AD; Alzheimer disease; ALS; amyotrophic lateral sclerosis; APOE4; apolipoprotein E4; APP; amyloid precursor protein; ASCL1; achaete-scute family basic helix-loop-helix transcription factor 1; ATP; adenosine trip
Keywords: Kruppel-like factor 4; Runt-related transcription factor 3; TGF-β1 signaling; Notch; lineage decision; monocyte differentiation; aN1; Active intracellular NOTCH1; DC; Dendritic cell; FITC; Fluorescein isothiocyanate; FLT3L; FMS-like tyrosine kinase 3 lig
Keywords: Anti-cancer therapies; Cancer attractors; Cancer stem cells; Hypoxia; Inflammation; Interactome; Metabolic modeling; Networks; Senescence; Signaling; AKT; RAC-alpha serine/threonine protein kinase; BMI1; polycomb ring finger oncogene; C/EBP; CCAAT/enhance
Keywords: AA; ascorbic acid; ALS; amyotrophic lateral sclerosis; BDNF; brain derived neurotropic factor; BMP; bone morphogenetic protein; DNMT; DNA methyltransferase; EB; embryoid body; EBNA1; Epstein-Barr nuclear antigen-1; ERK; extracellular signal-regulated ki
Keywords: ABCA; ATP-binding cassette transporter; AIM; Apoptosis inhibitor of macrophage; APC; antigen-presenting cell; ASC; apoptotic speck protein containing a caspase recruitment domain; AT; adipose tissue; ATM; AT macrophage; BLT; leukotriene B4 receptor; BM; b
Keywords: cDC; conventional dendritic cells; CDP; common dendritic cell precursors; cMoP; common monocyte progenitor; CMP; common myeloid precursors; CNS; central nervous system; DC; dendritic cells; GMP; granulocyte-macrophage precursors; HSC; hematopoietic stem c
Keywords: Prostate; Bladder; Differentiation; Pluripotent; Stem cells; Tissue engineering; Ureter; Urothelium; Androgen receptor; POU5F1 (formerly OCT4); SOX2; KLF4; MYC (formerly cMYC); NANOG;
Keywords: MiR-367; Osteosarcoma; Adriamycin; KLF4; Apoptosis; Chemotherapy resistance
Subcellular localization of Klf4 in non-small cell lung cancer and its clinical significance
Keywords: Klf4; non-small cell lung cancer; Subcellular localization; Cisplatin;
Hypertonic saline regulates microglial M2 polarization via miR-200b/KLF4 in cerebral edema treatment
Keywords: Hypertonic saline; Cerebral edema; Microglia M2 polarization; KLF4; miR-200b;
Peptidyl-prolyl isomerase Pin1 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in ApoEâ/â mice
Keywords: Abdominal aortic aneurysm; Pin1; Klf4; Smooth muscle; Phenotype switching; Ubiquitylation;
Is heterotopic ossification getting nervous?: The role of the peripheral nervous system in heterotopic ossification
Keywords: HO; heterotopic ossification; BMP; bone morphogenetic protein; BNB; blood-nerve barrier; TRPV1; transient receptor potential cation channel subfamily V member 1; sP; substance P; CGRP; Calcitonin gene-related protein; DRG; dorsal root ganglion; BBB; blood
KLF4 protects brain microvascular endothelial cells from ischemic stroke induced apoptosis by transcriptionally activating MALAT1
Keywords: KLF4; Endothelial cells; Ischemic stroke; MALAT1; Apoptosis; Inflammation;
Context-dependent functions of KLF4 in cancers: Could alternative splicing isoforms be the key?
Keywords: KLF4; Alternative splicing; Context-dependent function; Cancer;
Lysophosphatidylcholine induces expression of genes involved in cholesterol biosynthesis in THP-1 derived macrophages
Keywords: LPC; lysophosphatidylcholine; PCA; principal component analysis; FFA; free fatty acids; DMSO; dimethyl sulfoxide; FPKM; fragments per kilobase of transcript per million fragments mapped; RT-PCR; reverse transcription polymerase chain reaction; KEGG; Kyoto
Pancreatic DCLK1+ cells originate distinctly from PDX1+ progenitors and contribute to the initiation of intraductal papillary mucinous neoplasm in mice
Keywords: Pancreatic IPMN; DCLK1; SOX9; KLF4;
Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes
Keywords: Neuroinflammation; Microglia; Astrocytes; KLF4; IL-10; IL-1β; Honokiol;
Dynamic regulation of mRNA and miRNA associated with the developmental stages of skin pigmentation in Japanese ornamental carp
Keywords: DEGs; differentially expressed genes; DEMs; differentially expressed miRNAs; dph; days post hatching; mc1r; melanocortin 1 receptor; mitf; microphthalmia-associated transcription factor; tyr; tyrosinase; tyrp1; tyrosinase related protein 1; dct; dopachrom
FOXOs in cancer immunity: Knowns and unknowns
Keywords: 2B4; CD244 molecule; AKT or PKB; protein kinase B; APCs; antigen-presenting cells; ARG1; arginase 1; BEC; blood endothelial cell; BLNK; B cell Linker protein; BMP; bone morphogenetic protein; BTK; Bruton tyrosine kinase; C/EBP; CCAAT/enhancer-binding prot
Protostemonine attenuates alternatively activated macrophage and DRA-induced asthmatic inflammation
Keywords: AAM; alternatively activated macrophage; AHR; airway hyperresponsiveness; Arg-1; arginase-1; BALF; bronchoalveolar; BMDM; bone marrow derived macrophage; COPD; chronic obstructive pulmonary disease; DRA; dust mites, ragweed and aspergillus; Eos; eosinophi
KLF4 overcomes tamoxifen resistance by suppressing MAPK signaling pathway and predicts good prognosis in breast cancer
Keywords: Breast cancer; KLF4; MAPK; TAM resistance;
Dendritic cells conditioned by activin A-induced regulatory T cells exhibit enhanced tolerogenic properties and protect against experimental asthma
Keywords: Activin-A; allergic asthma; regulatory T cells; tolerogenic dendritic cells; immune regulation; Act-A-Treg; Activin-A-induced regulatory T; alum; Aluminum hydroxide; BAL; Bronchoalveolar lavage; BM-DCs; Bone marrow-derived dendritic cell; cDC; Convent
Effect of tetramethylpyrazine combined with cisplatin on VEGF, KLF4 and ADAMTS1 in Lewis lung cancer mice
Keywords: Non-small cell lung cancer; Tetramethylpyrazine; Cisplatin; ADAMTS1; VEGF; KLF4;
KLF4 expression enhances the efficacy of chemotherapy drugs in ovarian cancer cells
Keywords: KLF4; APTO-253; Chemoresistance; Ovarian cancer; Cell cycle;
Sp1 is a competitive endogenous RNA of Klf4 during odontoblast differentiation
Keywords: Odontoblast; Differentiation; ceRNAs; microRNAs; miRNA response elements; Sp1; Klf4;
MicroRNA-145 protects follicular granulosa cells against oxidative stress-induced apoptosis by targeting Krüppel-like factor 4
Keywords: miR-145; Granulosa cell; Oxidative stress; Apoptosis; KLF4; GCs; granulosa cells; ROS; reactive oxygen species; SOD1; superoxide dismutase 1; H2O2; hydrogen peroxide; KLF; Krüppel-like factor; LH; luteinizing hormone; IGF1; insulin-like growth factor 1;
Chickpea-supplemented diet alters the gut microbiome and enhances gut barrier integrity in C57Bl/6 male mice
Keywords: AB; Alcian Blue/Nuclear Fast red; BD; basal diet; CK; chickpea flour diet; EdU; 5-ethynyl-2â²-deoxyuridine; FITC; fluorescein isothiocyanate; FDR; false discovery rate; H&E; Haematoxylin & Eosin; JAM-A; Junctional adhesion molecule A; KEGG; Kyoto Encyclo
Deficiency of KLF4 compromises the lung function in an acute mouse model of allergic asthma
Keywords: KLF4; Asthma; Myeloid-derived suppressor cells (MDSCs); Fibrocytes; Thymic stromal lymphopoietin (TSLP); Airway hyperresponsiveness (AHR);
Myocardin: A novel player in atherosclerosis
Keywords: Myocardin; Atherosclerosis; Inflammation; Lipid metabolism; VSMC; Abca1; MYOCD; Myocardin; AS; atherosclerosis; SRF; serum response factor; VSMC; vascular smooth muscle cell; Mrtf-A/B; Myocardin-related transcription factors A/B; Mamstr; Mef2-activating S
Krüppel-like factor 4 (KLF4): What we currently know
Keywords: KLF4; Gene expression; Transcription; Tissues; Organs; Diseases; Proliferation; Differentiation; Cell cycle; Stem cells; Inflammation; Cancer; Epithelial-to-mesenchymal transition;
BMP4 promotes a phenotype change of an esophageal squamous epithelium via up-regulation of KLF4
Keywords: Barrett' s esophagus; HET-1A; DCA; KLF4; BMP4 signalling;
CCL5 deficiency reduces neointima formation following arterial injury and thrombosis in apolipoprotein E-deficient mice
Keywords: ApoE; Arterial thrombosis; CCL5; KLF4; Neointima
Skp1: Implications in cancer and SCF-oriented anti-cancer drug discovery
Keywords: Arf6; ADP-ribosylation factor 6; BIMEL; extra-long isoform of BIM; β-TRCP; β-transducin repeat-containing protein; CDCA3; cell division cycle associated 3; CDK; cyclin-dependent kinase; CENP-E; centrosome-associated protein E; Cks1; cyclin-dependent pro
Hypoxic inhibition of JMJD3 reduces H3K27me3 demethylation and induction of the STAT6 target gene CCL18
Keywords: C/EBPβ; CCAAT/enhancer binding protein (C/EBP), beta; c-myc; MYC = v-myc avian myelocytomatosis viral oncogene homolog; CBP; CREBBP = CREB binding protein; CCL18; chemokine (CC motif) ligand 18 (pulmonary and activation-regulated); CHX; cycloheximid;
Immunohistochemical study of Krüppel-like factor 4 in the spinal cords of rats with experimental autoimmune encephalomyelitis
Keywords: ABC; avidin-biotin-peroxidase-complex; CFA; complete Fruend's adjuvant; CNS; central nervous system; EAE; Experimental autoimmune encephalomyelitis; FITC; fluorescein isothiocyanate; GFAP; glial fibrillary acidic protein; iNOS; inducible nitric oxide
MiR-32 promotes gastric carcinoma tumorigenesis by targeting Kruppel-like factor 4
Keywords: Gastric cancer (GC); MiR-32; Kruppel-like factor 4 (KLF4); KLF4; Kruppel-like factor 4;
Vitamin D compounds reduce mammosphere formation and decrease expression of putative stem cell markers in breast cancer
Keywords: 1α,25(OH)2D3; 1α,25-dihydroxyvitamin D3; BCSC; breast cancer stem cell; DCIS; ductal carcinoma in situ; GATA3; GATA binding protein 3; IDC; invasive ductal carcinoma; KLF4; Kruppel-like factor 4; MFE; mammosphere forming efficiency; NFκB; nuclear facto
MALT1 induced immune response is governed by miR-2909 RNomics
Keywords: MALT1; paracaspase mucosa-associated lymphoid tissue 1; RIG1; retinoic acid-inducible gene 1; IFN-β; interferon-β; APOBEC3G; apo-lipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G; CCL5; chemokine (C-C motif) ligand 5; IL-17; interleuki
PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene
Keywords: ARF6; ADP ribosylation factor 6; BAC; bacterial artificial chromosome; BLAST; basic local alignment search tool; BSAP; B-cell lineage specific activator protein; BTK; Bruton's tyrosine kinase; CD; cluster of differentiation; Cq; quantitative PCR cycle; CT
Adenomatous polyposis coli (APC)-induced apoptosis of HT29 colorectal cancer cells depends on mitochondrial oxidative metabolism
Keywords: APC; adenomatous polyposis coli; CDX2; caudal-related homeobox 2; COX; cytochrome c oxidase; CRC; colorectal cancer; DNP; 2,4-dinitrophenol; FAP; familial adenomatous polyposis; HT29 APCi; HT29 APC inducible; HT29 βGal; HT29 β galactosidase; IRS1; insul
Using patient-specific induced pluripotent stem cells to interrogate the pathogenicity of a novel retinal pigment epithelium-specific 65Â kDa cryptic splice site mutation and confirm eligibility for enrollment into a clinical gene augmentation trial
Keywords: Best1; Bestrophin1; bFGF; basic fibroblast growth factor; DMEM; Dulbecco's Modified Eagle Medium; DNMT; DNA methyltransferases; ERG; Electroretinography; KLF4; Kruppel-like factor 4; LB; Lysogeny broth; LCA; Leber congenital amaurosis; MEM; minimum essent
miR-200c-SUMOylated KLF4 feedback loop acts as a switch in transcriptional programs that control VSMC proliferation
Keywords: ATRA; all-trans retinoic acid; cdk2; cyclin-dependent kinase 2; HASMC; human aortic smooth muscle cell; HDAC2; histone deacetylase 2; KLF; Krüppel-like factor; LSD1; lysine-specific demethylase 1; miR; microRNA; NCoR; nuclear receptor corepressor; p21; p
Sensitization to autoimmune hepatitis in group VIA calcium-independent phospholipase A2-null mice led to duodenal villous atrophy with apoptosis, goblet cell hyperplasia and leaked bile acids
Keywords: AB-PAS; alcian blue-periodic acid schiff; AIH; autoimmune hepatitis; ALT; alanine aminotransferase; AP; alkaline phosphatase; AST; aspartate aminotransferase; Bcl-2; B-cell lymphoma 2; CA; cholic acid; CCL; chemokine ligand; CCR; chemokine receptor; CDCA;