Keywords: NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; FC; free cholesterol; VLDL; very low density lipoprotein; LDL; low density lipoprotein; mTOR; mechanistic target of rapamycin signaling; AMPK; AMP-activated protein kinase; TG; t
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Keywords: IUGR; intrauterine growth retardation; PNE; prenatal nicotine exposure; TCH; total cholesterol; HDL-C; high-density lipoprotein-cholesterol; LDL-C; low-density lipoprotein-cholesterol; SR-B1; scavenger receptor class B type 1; ABCA1; ATP-binding cassette
Keywords: Rare disease; Sterol; Homeostasis; Sterol regulatory element binding protein-2; ABCG8; ATP-binding cassette sub-family G member 8; SREBP-2; Sterol regulatory element-binding protein 2; LDL; low-density lipoprotein; HMGCR; 3-Hydroxy-3-Methylglutaryl-CoA re
Keywords: Genetic regulation; Transcription factor; Nonlinear ordinary differential equation; SREBP-2;
Keywords: ALP; alkaline phosphatase; ALT; alanine amino trasnferase; AST; aspartate amino trasnferase; CONT; a control diet; GAPDH; glyceraldehydes-3-phosphate dehydrogenase; HDL; high-density lipoprotein; HMG-CoA; 5-hydroxy-3-methylglutaryl-CoA; LDL; low-density l
MicroRNA-98 regulates hepatic cholesterol metabolism via targeting sterol regulatory element-binding protein 2
Keywords: MiR-98; Cholesterol metabolism; SREBP-2; HMG-CoA reductase;
Long noncoding RNA lncARSR promotes hepatic cholesterol biosynthesis via modulating Akt/SREBP-2/HMGCR pathway
Keywords: lncARSR; Cholesterol; HMG-CoA reductase; SREBP-2; PI3K/Akt;
Behavior of three hypocholesterolemic peptides from soy protein in an intestinal model based on differentiated Caco-2 cell
Keywords: Hypocholesterolemic peptides; Caco-2 cells; DPP-IV; HMGCoAR; In silico docking; Intestinal absorption; LC-MRM; Mass spectrometry; Soy protein; ACN; acetonitrile; AP; apical; BL; basolateral; CV; coefficient of variance; DMEM; Dulbecco's Modified Eagle M
Lysophosphatidylcholine induces expression of genes involved in cholesterol biosynthesis in THP-1 derived macrophages
Keywords: LPC; lysophosphatidylcholine; PCA; principal component analysis; FFA; free fatty acids; DMSO; dimethyl sulfoxide; FPKM; fragments per kilobase of transcript per million fragments mapped; RT-PCR; reverse transcription polymerase chain reaction; KEGG; Kyoto
DNA methylation signatures at endoplasmic reticulum stress genes are associated with adiposity and insulin resistance
Keywords: Endoplasmic reticulum; Epigenetics; Obesity; Triglycerides; Insulin resistance; BMI; body mass index; CASP12; caspase 12; CpG; cytosine-phosphate-guanine site; DBP; diastolic blood pressure; DiOGenes; diet obesity and genes dietary trial; DNAJC1; dnaJ hea
Cholesterol-lowering effect of Aralia elata (Miq.) Seem via the activation of SREBP-2 and the LDL receptor
Keywords: Aralia elata (Miq.) Seem; Cholesterol; HMG-CoA; LDL-R; SREBP-2;
Cassia auriculata flower extract attenuates hyperlipidemia in male Wistar rats by regulating the hepatic cholesterol metabolism
Keywords: Et- CAF; ethanolic extract of Cassia auriculata flower; HMGR; HMG-CoA reductase; HMGS; HMGCoA synthase; SREBP-1c; sterol regulatory element binding protein -1c; SREBP-2; sterol regulatory element binding protein- 2; CYP7A1; cholesterol 7 α-hydroxylase; A
Neoagarooligosaccharides enhance the level and efficiency of LDL receptor and improve cholesterol homeostasis
Keywords: LDL cholesterol; LDL receptor; Neoagarooligosaccharides; PCSK9; SREBP-2; ALT; alanine aminotransferase; AOS; agaro-oligosaccharides; AST; aspartate aminotransferase; CHD; coronary heart disease; DNS; dinitrosalicylic acid; DP; degree of polymerization; HC
New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis
Keywords: ChIP-seq; chromatin immunoprecipitation-sequencing; DHCR7; 7-dehydrocholesterol reductase; DHCR24; 24-dehydrocholesterol reductase; EMSA; electrophoretic mobility shift assay; FCLPDS; fetal calf lipoprotein-deficient serum; FCS; fetal calf serum; HMGCR; 3
NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition
Keywords: 1-25-diOH D; dihydroxyvitamine D; 25-OH D; 25-hydroxyvitamin D; APO; apolipoprotein; BMI; body mass index; ER; endoplasmic reticulum; FC; free cholesterol; FFAs; free fatty acids; FGF-2; fibroblast growth factor 2; FXRÉ; farnesoid X receptor α; HDL; hig
Double blind exploratory study on de novo lipogenesis in preterm infants on parenteral nutrition with a lipid emulsion containing 10% fish oil
Keywords: Lipids; Isotope labeling; Lipogenesis; Premature infants; Omega-3 fatty acids; Omega-6 fatty acids; ASR; absolute synthesis rate; CE; cholesterol esters; C16-CE; cholesterol esters palmitate; C16-PL; phospholipids palmitate; C16-TG; triglycerides palmitat
Possible involvement of PCSK9 overproduction in hyperlipoproteinemia associated with hepatocellular carcinoma: A case report
Keywords: Hypercholesterolemia; Hypertriglyceridemia; Type III hyperlipoproteinemia; Cholesterol; Liver; Hepatocellular carcinoma; PCSK9; SREBP-2; LDL receptor; Hepatitis B virus;
DHCR7: A vital enzyme switch between cholesterol and vitamin D production
Keywords: 7DHC; 7-dehydrocholesterol; AEBS; antiestrogen binding site; DHCR7; 7-dehydrocholesterol reductase; DHCR14; Î14-sterol reductase; DHCR24; 24-dehydrocholesterol reductase; EBP; emopamil binding protein; Hh; Hedgehog; HMGCR; 3-hydroxy-3-methylglutaryl-CoA
Physiological feedback regulation of cholesterol biosynthesis: Role of translational control of hepatic HMG-CoA reductase and possible involvement of oxylanosterols
Keywords: HMG-CoA reductase; 3-hydroxy-3-methylgutaryl coenzyme A reductase; LDL; low density lipoprotein; HDL; high density lipoprotein; SRE; sterol response element; SREBP-2; sterol response element binding protein-2; Scap; SREBP cleavage-activating protein; Insi
Alginate oligosaccharide enhances LDL uptake via regulation of LDLR and PCSK9 expression
Keywords: AOS; alginate oligosaccharide; CVD; cardiovascular disease; FH; familial hypercholesterolemia; GSK3β; glycogen synthase kinase 3β; HINFP; histone nuclear factor P; HMG-CoA; 3-hydroxy-3-methylglutaryl-coenzyme A; HNF; hepatocyte nuclear factor; Insig; in
Enediynyl peptides and iso-coumarinyl methyl sulfones as inhibitors of proprotein convertases PCSK8/SKI-1/S1P and PCSK4/PC4: Design, synthesis and biological evaluations
Keywords: aa; amino acid; AMC; 7-amino 4-methyl coumarin; Amu; atomic mass unit; Au; arbitrary unit; Aufs; absorption units full scale; IMS; iso-coumarinyl methyl sulfone; Eda; enediyne amino acid; h; human; IC50; inhibitor concentration required for 50% inhibition
24S,25-Epoxycholesterol in mouse and rat brain
Keywords: HMG-CoA; 3-hydroxy-3-methyl-glutaryl-CoA; APCI; atmospheric pressure chemical ionisation; API; atmospheric pressure ionisation; BBB; blood brain barrier; CNS; central nervous system; Ctx; cortex; CYP or Cyp; cytochrome P450; DDA; data dependent analysis;
Cholesterol-lowering effect of Lactobacillus plantarum NCU116 in a hyperlipidaemic rat model
Keywords: CVDs; cardiovascular diseases; CYP7A1; cholesterol 7α-hydroxylase; HDL-C; high-density lipoprotein cholesterol; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; LDL-C; low-density lipoprotein cholesterol; SREBP-2; sterol regulatory element-binding protein
The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis
Keywords: 7DHC; 7-dehydrocholesterol; DHCR7; 7-dehydrocholesterol reductase; DHCR24; 24-dehydrocholesterol reductase; LDLR; low-density lipoprotein receptor; NF-Y; nuclear factor-Y; NPC1L1; Niemann-pick C1 like-1; SLOS; Smith-Lemli-Opitz Syndrome; Sp1; specific
Accumulation of lipids and oxidatively damaged DNA in hepatocytes exposed to particles
Keywords: ABCG5; ATP-binding cassette, sub-family G (WHITE), member 5; ABCG8; ATP-binding cassette, sub-family G (WHITE), member 8; CB; carbon black; DEP; diesel exhaust particles; FASN; fatty acid synthase; FFA; free fatty acids; FPG; formamidopyrimidine DNA glyco
Cholesterol biosynthesis and ER stress in peroxisome deficiency
Keywords: Peroxisomes; Cholesterol; Isoprenoid; Pex2; SREBP-2; ER stress; Integrated stress response; Unfolded protein response; Zellweger syndrome; ACAT; acetoacetyl-CoA thiolase; ATF; activating transcription factor; BA; bile acid; CHOP; C/EBP homologous protein;
Pectin pentasaccharide from hawthorn (Crataegus pinnatifida Bunge. Var. major) ameliorates disorders of cholesterol metabolism in high-fat diet fed mice
Keywords: HMGCR; 3-hydroxy-3-methyl-glutaryl-CoA reductase; SREBP-2; sterol regulatory element-binding protein 2; LDLR; low density lipoprotein receptor; CYP7A1; cholesterol 7α-hydroxylase; ACAT; acyl-coenzyme A: cholesterol acyl-transferase; Actb; actin beta; HPP
Lipopolysaccharide downregulates CD91/low-density lipoprotein receptor-related protein 1 expression through SREBP-1 overexpression in human macrophages
Keywords: Lipopolysaccharide; Aggregated LDL; Human macrophages; LRP1; LDLR; SREBP-1; SREBP-2;
Activation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase during high fat diet feeding
Keywords: HMG-CoA reductase; Cholesterol; SREBP-2; Fatty liver
Acetoacetyl-CoA synthetase is essential for normal neuronal development
Keywords: Ketone body; SREBP-2; Acetoacetyl-CoA synthetase; Neuronal development
DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet
Keywords: Docosahexaenoic acid; Docosapentaenoic acid; Total cholesterol; HMG-CoA reductase; SREBP-2; Vascular reactivity;
Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levels
Keywords: Ketone body; Cholesterol; SREBP-2; Acetoacetyl-CoA synthetase;
Endoplasmic reticulum stress-mediated inhibition of NSMase2 elevates plasma membrane cholesterol and attenuates NO production in endothelial cells
Keywords: NO; nitric oxide; ER; endoplasmic reticulum; BAEC; bovine aortic endothelial cells; eNOS; endothelial nitric oxide synthase; NSMase or NSM; neutral sphingomyelinase; SREBP-2; sterol-responsive element-binding protein; Tm; tunicamycin; Pm; palmitate; RNAi;
Phaleria macrocarpa (Scheff.) Boerl fruit aqueous extract enhances LDL receptor and PCSK9 expression in vivo and in vitro
Keywords: apo-B; apolipoprotein B; BSA; bovine serum albumin; CETP; cholesterol ester transfer protein; HDL; high density lipoprotein; HMG-CoA; 3-hydroxy-3-methyl-glutaryl-CoA reductase; LDL; low density lipoprotein; PBS; phosphate buffer saline; PCSK9; proprotein
Hypocholesterolemic activity of grape seed proanthocyanidin is mediated by enhancement of bile acid excretion and up-regulation of CYP7A1
Keywords: Cholesterol; Grape seed proanthocyanidin; CYP7A1; LDL receptor; HMG-CoA reductase; SREBP-2; Liver X receptor
Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box
Keywords: SRE; sterol regulatory element; SREBP-2; SRE-binding protein 2; NF-Y; nuclear factor Y; LDLR; low density lipoprotein receptor; FBS; foetal bovine serum; Lov; lovastatin; 25-OH chol; 25-hydroxycholesterol; LPDS; lipoprotein deficient serum; EMSA; electrop
Selective role of sterol regulatory element binding protein isoforms in aggregated LDL-induced vascular low density lipoprotein receptor-related protein-1 expression
Keywords: Aggregated LDL; LRP1; SREBP-1a; SREBP-1c; SREBP-2; Human VSMC
Pitavastatin induces PON1 expression through p44/42 mitogen-activated protein kinase signaling cascade in Huh7 cells
Keywords: Paraoxonase; HMG-CoA reductase inhibitor; ERK; SREBP-2; Sp1
Regulation of steroid 5-α reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin
Keywords: Srd5a2; Steroid 5-α reductase type 2; SREBP; sterol regulatory element binding protein; HMG; 3-hydroxy-3-methylglutaryl; ChIP; chromatin immunoprecipitation; qPCR; quantitative PCR; L/E; lovastatin and ezetimibe; LDLR; low density lipoprotein receptor; S
Localization of the transcription factor, sterol regulatory element binding protein-2 (SREBP-2) in the normal rat brain and changes after kainate-induced excitotoxic injury
Keywords: SREBP-2; Hippocampus; Cerebral cortex; Striatum; Dendrites; Cholesterol biosynthesis; Excitotoxicity
Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH
Keywords: NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; FFA; free fatty acids; TG; triglycerides; SREBP-2; sterol regulatory element-binding protein-2; SREBP-1c; sterol regulatory element-binding protein-1c; HMG-CoA reductase; hydro
Inhibitory effect of novel diallyldisulfide analogs on HMG-CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target
Keywords: Diallyldisulfide; HMG-CoA reductase; SREBP-2; CREB; NF-Y; NF-κB
Rapamycin down-regulates LDL-receptor expression independently of SREBP-2
Keywords: SREBP-2; Rapamycin; Sirolimus; mTOR; LDL-receptor; Hyperlipidemia;
Overexpression of A-kinase anchoring protein 12A activates sterol regulatory element binding protein-2 and enhances cholesterol efflux in hepatic cells
Keywords: AKAP12/Gravin; SREBP-2; Cholesterol; U18666A; Cholesterol efflux
Inability to fully suppress sterol synthesis rates with exogenous sterol in embryonic and extraembyronic fetal tissues
Keywords: SLOS; Smith-Lemli-Opitz syndrome; DHCR7; 3β-hydroxysterol Î7-reductase; HMGR; HMG-CoA reductase; SREBP; sterol regulatory element binding protein; SCAP; SREBP cleavage-activating protein; DPS; digitonin-precipitable sterols; Shh; Sonic hedgehog; Cho
Activation of the hepatic LDL receptor promoter by thyroid hormone
Keywords: LDL receptor promoter activity; Cholesterol domeostasis; Thyroid hormone response element; Rat liver; Thyroid receptor β1; SREBP-2; Sterol response element
LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2
Keywords: CLA, conjugated linoleic acid; LA, linoleic acid; SREBP, sterol regulatory element binding protein; HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductaseConjugated linoleic acid; LDL receptor; Atherosclerosis; SREBP-2; SREBP-1
Sterol Regulatory Element-binding Protein-2 Negatively Regulates Low Density Lipoprotein Receptor-related Protein Transcription
Keywords: LRP1; SREBP-2; down-regulationLDL, low density lipoprotein; agLDL, aggregated LDL; LDLR, LDL receptor; SRE, sterol regulatory element; SREBP-2, sterol regulatory element binding protein; VSMC, vascular smooth muscle cells; LRP1, low density lipoprotein re