Keywords: Aml; amlodipine; Ca2+; free calcium; DHP; dihydropyridine; Dil; diltiazem; Epo; erythropoietin; EpoR; erythropoietin receptor; FBS; fetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; PBS; phosphate-buffered saline; Pyr3; TRPC3 inhibitor;
مقالات ISI (ترجمه نشده)
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Keywords: ER stress; KSHV; IRE1α; PERK; Primary effusion lymphoma; Unfolded protein response; ATF6; activating transcription factor-6; CHOP; CCAAT/enhancer-binding protein-homologous protein; ER; endoplasmic reticulum; GADD34; growth arrest and DNA damage gene-34;
Keywords: BiP; Binding protein; CCL2; Chemokine (C-C motif) ligand 2; CCL3; Chemokine (C-C motif) ligand 3; CCL5; Chemokine (C-C motif) ligand 5; C/EBP; CCAAT/enhancer binding protein; CHOP; C/EBP homologous protein; Ct; Comparative threshold cycle;; eIF2α; Eukary
Keywords: Thapsigargin; Nortrilobolide; Semisynthesis; Mn(OAc)3; αâ²-Acyloxylation;
Keywords: ER; endoplasmic reticulum; THG; thapsigargin; PDI; protein disulfide isomerase; TMX; thioredoxin-related-transmembrane proteins; UPR; unfolded protein response; PERK; pancreatic ER kinase PKR-like ER kinase; ATF6; activating transcription factor-6; IRE1;
Keywords: Islets; Beta-cells; Cytokines; Calcium; Insulin; Low-grade inflammation; Diabetes; Chronic; Free fatty acid; Palmitate; Oleate; Linoleate; Glucotoxicity; High glucose; Endoplasmic reticulum; Thapsigargin; Unfolded protein response; ER stress; Oxidative st
Keywords: SOCE; store-operated calcium entry; SOC; store-operated channel; Stim1; stromal interaction molecule 1; UDP; uridine diphosphate; ATP; adenosine triphosphate; LPS; lipopolysaccharide; TG; thapsigargin; 2-APB; 2-aminoethoxyldiphenyl borate; TNF-α; tumor n
Keywords: 7-AAD; aminoactinomycin; ANT; adenine nucleotide translocator; CI; combination index; CREB; cyclic AMP response element binding protein; DMSO; dimethyl sulfoxide; E; epicatechin; ELISA; enzyme-linked immunosorbent assay; ER; endoplasmic reticulum; FCCP; c
Keywords: [Ca2+]i; intracellular concentrations of Ca2+; CalC; calphostin C; DAG; diacylglycerol; E2; estradiol; EOG; electro-olfactogram; ER; endoplasmic reticulum; F340/F380; ratio of fluorescence intensity excited at 340Â nm and 380Â nm; HBSS; HEPES buffered sta
Keywords: ACF; aberrant crypt foci; AMC; 7-amino-4-methyl coumarin; Akt1; v-akt murine thymoma viral oncogene homolog 1; ATCC; American Type Culture Collection; CCL; culture clone; CHO; Chinese hamster ovary cells; CPA; cyclopiazonic acid; D9R; nona-d-arginine; DME
Keywords: ER; endoplasmic reticulum; UPR; unfolded protein response; PERK; double-stranded RNA-activated protein kinase (PKR)-like ER kinase; ATF-6; activating transcription factor 6; IRE1; inositol requiring enzyme 1; Bip; luminal binding protein (also known as GR
The organophosphorus pesticide dimethoate decreases cell viability and induces changes in different biochemical parameters of rat pancreatic stellate cells
Keywords: Calcium; Dimethoate; Esterase activity; Organophosphorus insecticide; Pancreatic stellate cells; ACh; Acetylcholine; AChE; Acetylcholinesterase; BChE; Butyrylcholinesterase; [Ca2+]i; Intracellular free Ca2+ concentration; CbEs; Carboxylesterases; ChE; Cho
The interaction between calcineurin and α-synuclein is regulated by calcium and calmodulin
Keywords: Alpha-synuclein; Calcineurin; Microscale thermophoresis; GST pull-down assays; Co-immunoprecipitation; Thapsigargin;
Effects of gamma irradiation and comparison of different extraction methods on sesquiterpene lactone yields from the medicinal plant Thapsia garganica L. (Apiaceae)
Keywords: Thapsia garganica; Gamma irradiation; Microwave assisted extraction; Thapsigargin; Antioxidant;
Ca2+ mediates axotomy-induced necrosis and apoptosis of satellite glial cells remote from the transection site in the isolated crayfish mechanoreceptor
Keywords: AT; axotomized preparation; CICR; calcium-induced calcium release; CsA; cyclosporin A; CSR; crayfish stretch receptor; MRN; mechanoreceptor neuron; Int; intact preparation; Im; ionomycin; MPTP; mitochondrial permeability transition pore; Rya; ryanodine; T
Store-independent coupling between the Secretory Pathway Ca2+ transport ATPase SPCA1 and Orai1 in Golgi stress and Hailey-Hailey disease
Keywords: ER; endoplasmic reticulum; GASE; Golgi apparatus stress recognition element; HHD; Hailey-Hailey Disease; KD; knockdown; NFAT; nuclear factor of activated T cells; NT; non-targeting; ROI; region of interest; SICE; store-independent Ca2+ entry; SOCE; store-
Steroids from Helleborus caucasicus reduce cancer cell viability inducing apoptosis and GRP78 down-regulation
Keywords: Helleborus caucasicus; Ecdysteroids; Bufadienolides; Cell viability; Apoptosis; GRP78; DMSO; dimethylsulfoxide; MTT; 3-(4,5 dimethylthiazol-2-yl)-2,5diphenyltetrazolium; BrdU; bromodeoxyuridine; DEVD; Asp-Glu-Val-Asp; pNA; p-nitroanilide; VP16; Etoposide;
Hepatitis B virus suppresses the secretion of insulin-like growth factor binding protein 1 to facilitate anti-apoptotic IGF-1 effects in HepG2 cells
Keywords: CHB; chronic hepatitis B; HBV; hepatitis B virus; HBx; HBV X protein; HCC; hepatocellular carcinoma; IGF-1; insulin-like growth factor 1; IGFBP1; insulin-like growth factor binding protein 1; STS; staurosporine; TG; thapsigargin; HBs; viral surface protei
CDNF induces the adaptive unfolded protein response and attenuates endoplasmic reticulum stress-induced cell death
Keywords: CDNF; UPR; ER stress; Thapsigargin;
Major Role for TRPV1 and InsP3R in PAR2-Elicited Inflammatory Mediator Production in Differentiated Human Keratinocytes
Keywords: DhPK; differentiated human primary keratinocytes; InsP3; inositol 1,4,5-triphosphate; InsP3R; inositol 1,4,5-triphosphate receptor; KSFM; keratinocyte serum-free medium; PLC; phospholipase C; siRNA; small interfering RNA; SOCE; store-operated Ca2+ entry;
Rab7a modulates ER stress and ER morphology
Keywords: BiP; binding immunoglobulin protein; CHOP; CCAAT-enhancer-binding protein homologous protein; CLIMP63; 63-kDa cytoskeleton-linking membrane protein; ER; endoplasmic reticulum; LEs; late endosomes; GDP; guanine diphosphate; GTP; guanine triphosphate; NT; n
Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death
Keywords: AUC; area under the curve; EpoTg; thapsigargin epoxide; ER; endoplasmic reticulum; LDH; lactate dehydrogenase; PI; propidium iodide; SERCA; sarco/endoplasmic reticulum Ca2+-ATPase; SOCE; store-operated calcium entry; Tg; thapsigargin; UPR; unfolded protei
Hepatitis B virus upregulates host microRNAs that target apoptosis-regulatory genes in an in vitro cell model
Keywords: cFLIP; cellular FLICE-inhibitory protein; CHB; chronic hepatitis B; ER; endoplasmic reticulum; HBV; hepatitis B virus; HBx; HBV X protein; HCC; hepatocellular carcinoma; MOMP; mitochondrial outer membrane permeabilization; SODD; silencer of death domains;
Endoplasmic reticulum stress-dependent ROS production mediates synovial myofibroblastic differentiation in the immobilization-induced rat knee joint contracture model
Keywords: ATF6; activating transcription factor 6; ATF6α; activating transcription factor 6 alpha; CHOP; C/EBP homology protein; DMSO; dimethylsulphoxide; DCHF-DA; 2â²,7â²-dichlorofluorescein diacetate; DPI; diphenyleneiodonium; ER; endoplasmic reticulum; GAPDH;
Sulfanilic acid increases intracellular free-calcium concentration, induces reactive oxygen species production and impairs trypsin secretion in pancreatic AR42J cells
Keywords: AR42J cells; Calcium; Pancreas; ROS; Sulfanilic acid; Trypsin secretion; BAPNA; Nα-Benzoyl-dl-arginine 4-nitroanilide hydrochloride; Dimethyl BAPTA/AM; 1,2-bis(2-amino-5-methylphenoxy) ethane-N,N,Nâ²,Nâ²-tetraacetic acid tetrakis(acetoxymethyl) ester;
Mechanisms controlling the multistage post-translational processing of endogenous Nrf1α/TCF11 proteins to yield distinct isoforms within the coupled positive and negative feedback circuits
Keywords: Nrf1; DDI-1/2; p97; Proteoform; Proteasome; Post-Translational Modification; Proteolysis; ER Stress; Hrd1; BTZ; bortezomib; CNC; cap 'n' collar; CHX; cycloheximide; DDI-1; DNA-damage inducible protein homolog 1; Epox; expoxomicin; ER; endoplasmic reticulu
Protective effects of isorhamnetin on N2a cell against endoplasmic reticulum stress-induced injury is mediated by PKCε
Keywords: ERS; endoplasmic reticulum stress; Iso; isorhamnetin; TG; Thapsigargin; ROS; reactive oxygen species; PKCε; Protein kinase C epsilon; Endoplasmic reticulum stress; Isorhamnetin; Neuroprotection; Protein kinase C epsilon;
Store-operated calcium entry is dispensable for the activation of ERK1/2 pathway in prostate cancer cells
Keywords: EGF; epidermal growth factor; ER; endoplasmic reticulum; ERK; extracellular signal-regulated kinase; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; SOCE; store-operated calcium entry; Tg; thapsigargin; Calcium; CRISPR; ERK1/2; SOCE;
HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases
Keywords: CHOP; CCAAT-enhancer-binding protein homologous protein; Di-E-GSSG; dieosin glutathione disulfide; DiOC6(3); 3,3â²-dihexyloxacarbocyanine iodide; DTT; dithiothreitol; GSSG; oxidized glutathione; ER; endoplasmic reticulum; EGSH; eosin-coupled glutathione;
Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention
Keywords: CFTR; cystic fibrosis transmembrane conductance regulator; ER; endoplasmic reticulum; CF; cystic fibrosis; SERCA; sarco/endoplasmic reticulum Ca2+ ATPase; PMCA; plasma membrane Ca2+ ATPase; TG; thapsigargin; F508del-CFTR; Calumenin; SERCA; ER Ca2+ homeost
Coupling between the TRPC3 ion channel and the NCX1 transporter contributed to VEGF-induced ERK1/2 activation and angiogenesis in human primary endothelial cells
Keywords: BAPTA-AM; 1,2-bis(2-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid tetrakis(acetoxymethyl ester); CRAC; Ca2Â +-release activated Ca2Â + channel; [Ca2Â +]i; cytosolic Ca2Â + concentration; DAG; diacylglycerol; EC; endothelial cell; eNOS; endothelial ni
Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology, and therapeutic roles
Keywords: AAV; adeno-associated virus; AKI; acute kidney injury; ARMET; arginine-rich mutated in early tumors; ATF6; activating transcription factor 6; BiP; Ig-binding protein; CDNF; conserved dopamine neurotrophic factor; CHOP; C/EBP homologous protein; DM; diabet
Cortical cytoskeleton dynamics regulates plasma membrane calcium ATPase isoform-2 (PMCA2) activity
Keywords: PMCA; plasma membrane calcium ATPase; (SERCA); (sarco)endoplasmic reticulum calcium ATPase; (HEK298 cells); human embryonic kidney 298 cells; (CytD); cytochalasin D; (JAS); jasplakinolide; (Col); colchicine; (TG); thapsigargin; (SOC); store operated chann
Metformin attenuates ER stress-induced mitochondrial dysfunction
Keywords: AIF; apoptosis inducing factor; AMPK; AMP-activated protein kinase; ASPP2; apoptosis-stimulating protein of p53-2; ADP; adenosine diphosphate; ATP; adenosine triphosphate; CHOP; C/EBP homologous protein; BSA; bovine serum albumin; CRC; calcium retention c
Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury
Keywords: Ad; adenovirus; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ATF6; activating transcription factor 6; ChIP; chromatin immunoprecipitation; CHOP; C/EBP homologous protein; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxid
Stress granules assembly affects detection of mRNA in living cells by the NanoFlares; an important aspect of the technology
Keywords: ARE; AU-rich element; ATF-4; activating transcription factor 4; BRCA1; breast cancer type 1 susceptibility; CML; chronic myeloid leukemia; eIF2α; eukaryotic initiation factor subunit α; EM; emetine; ER; endoplasmic reticulum; FBS; fetal bovine serum; mR
The dynamics of histone H2A ubiquitination in HeLa cells exposed to rapamycin, ethanol, hydroxyurea, ER stress, heat shock and DNA damage
Keywords: DNA damage; ER stress; Heat shock; Histone H2A; Stress response; Ubiquitin; ER; endoplasmic reticulum; hH2A; histone H2A; HU; hydroxyurea; MMS; methyl methanesulfonate; Tg; thapsigargin; Tm; tunicamycin; Rap; rapamycin; Ub; ubiquitin;
Original ArticleRepression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis
Keywords: Apoptosis; Myeloma; Mcl-1; Bak; ER stress; MM; multiple myeloma; HMCLs; Human myeloma cell line(s); Tg; Thapsigargin; CHX; cycloheximide;
Herp depletion inhibits zearalenone-induced cell death in RAW 264.7 macrophages
Keywords: Atg; autophagy-related proteins; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; ER; endoplasmic reticulum; ERAD; ER-associated protein degradation; FBS; fetal bovine serum; Fisher LSD; Fisher's least significant different test; GS; gl
Involvement of mitochondrial permeability transition pore (mPTP) in cardiac arrhythmias: Evidence from cyclophilin D knockout mice
Keywords: CaWs; Ca2+ waves; FCCP; carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone; CsA; cyclosporin A; CypD KO; CypD knockout mouse model; DHPR, α1 subunit of L-type Ca channel; dihydropyridine receptor; Cai2+; intracellular Ca2+; I/R; ischemia/reperfusion;
Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway
Keywords: Apoptosis; Autophagy; Thapsigargin; ROS; HepG2 cells
Thapsigargin-induced activation of Ca2+-CaMKII-ERK in brainstem contributes to substance P release and induction of emesis in the least shrew
Keywords: Thapsigargin; Emesis; Brainstem; Substance P; ERK; LTCC;
Role of miR-181a-5p and endoplasmic reticulum stress in the regulation of myogenic differentiation
Keywords: ATF6; activating transcription factor 6; BMP4; bone morphogenetic protein 4; DM; differentiation medium; ER; endoplasmic reticulum; GM; growth medium; GRP78/BIP; glucose-regulated protein of 78Â kDa/binding protein for immunoglobulins; IGF-1; insulin-like
Calmidazolium evokes high calcium fluctuations in Plasmodium falciparum
Keywords: 2-APB; 2-aminoethoxydiphenylborate; AC; acidic calcium stores; BSA; bovine serum albumin; CaM; calmodulin; CaMRs; CaM-related proteins; CZ; calmidazolium; [Ca2Â +]cyt; cytosolic calcium concentration; [Ca2Â +]mit; mitochondrial calcium concentration; EGTA
Role of SERCA and the sarcoplasmic reticulum calcium content on calcium waves propagation in rat ventricular myocytes
Keywords: Calcium waves; SERCA; Ryanodine receptors; Ventricular myocytes; Beta-adrenergic stimulation; Calcium-triggered arrhythmias; SR; sarcoplasmic reticulum; RyR2; ryanodine receptors type 2; CICR; Ca2+-induced Ca2+ release; Êwave; Ca2+ wave propagation rate;
DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress
Keywords: Apaf1; apoptotic protease activating factor-1; Bcl-2; B cell lymphoma 2; DKO; Bax Bak double knockout; Drp1; Dynamin Related Protein 1; ER; endoplasmic reticulum; IMM; inner mitochondrial membrane; MEFs; mouse embryonic fibroblasts; MFN; mitofusin; MOMP;
Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum Ca2+ content in primary hippocampal neurons
Keywords: Ca2+ signaling; Hippocampus; Thapsigargin; Neuronal RyR function;
ER and Golgi stresses increase ER-Golgi SNARE Syntaxin5: Implications for organelle stress and βAPP processing
Keywords: Aβ peptide; amyloid-β peptide; AD; Alzheimer's disease; BFA; brefeldin A; βAPP; β-amyloid precursor protein; DIV; day in vitro; ELISA; enzyme linked immunosorbent assay; ER; endoplasmic reticulum; SERCA; sarco/endoplasmic reticulum Ca2+-ATPase; siRNA;
Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca2+ pumps with a unique mode of binding
Keywords: BHC; benzene hexachloride; BHQ; 2,5-di-tert-butyl-1,4-benzohydroquinone; BLLA; biselyngbyolide A; BLLB; biselyngbyolide B; BLS; biselyngbyaside; BLSC; baselyngbyaside C; C12E8; octaethyleneglycol-n-dodecylether; CPA; cyclopiazonic acid; JFCR39; Japanese F
Targeting thapsigargin towards tumors
Keywords: Thapsigargin; Sarco/endoplasmic reticulum (SERCA); Prodrug; Prostate specific antigen (PSA); Prostate specific membrane antigen (PSMA); Targeting drugs