Structure of Complement Component C2a: Implications for Convertase Formation and Substrate Binding Fulltext Access 11 Pages 2006
Regulatory Functions of Nuclear Hexokinase1 Complex in Glucose Signaling Fulltext Access 11 Pages 2006
Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration Fulltext Access 11 Pages 2006
Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi Fulltext Access 11 Pages 2006
Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival Fulltext Access 11 Pages 2006
Tumor Morphology and Phenotypic Evolution Driven by Selective Pressure from the Microenvironment Fulltext Access 11 Pages 2006
Reciprocal Gut Microbiota Transplants from Zebrafish and Mice to Germ-free Recipients Reveal Host Habitat Selection Fulltext Access 11 Pages 2006
RETRACTED: Role of the Sigma Factor in Transcription Initiation in the Absence of Core RNA Polymerase Fulltext Access 11 Pages 2006
Meiotic Proteins Bqt1 and Bqt2 Tether Telomeres to Form the Bouquet Arrangement of Chromosomes Fulltext Access 11 Pages 2006
Crystal Structures of T. brucei MRP1/MRP2 Guide-RNA Binding Complex Reveal RNA Matchmaking Mechanism Fulltext Access 11 Pages 2006
Capsid Conformational Sampling in HK97 Maturation Visualized by X-Ray Crystallography and Cryo-EM Fulltext Access 11 Pages 2006
Crystal Structure of Human Iron Regulatory Protein 1 as Cytosolic Aconitase Fulltext Access 11 Pages 2006
Activation and Catalysis of the Di-Heme Cytochrome c Peroxidase from Paracoccus pantotrophus Fulltext Access 11 Pages 2006
Mapping the Structure and Function of the E1 and E2 Glycoproteins in Alphaviruses Fulltext Access 11 Pages 2006
A Second FMN Binding Site in Yeast NADPH-Cytochrome P450 Reductase Suggests a Mechanism of Electron Transfer by Diflavin Reductases Fulltext Access 11 Pages 2006
The Structure of the N-Terminal Domain of the Fragile X Mental Retardation Protein: A Platform for Protein-Protein Interaction Fulltext Access 11 Pages 2006
Structure and Specific RNA Binding of ADAR2 Double-Stranded RNA Binding Motifs Fulltext Access 11 Pages 2006
Molecular Basis for Phosphorylation-Dependent, PEST-Mediated Protein Turnover Fulltext Access 11 Pages 2006
Structural and Functional Aspects of the Sensor Histidine Kinase PrrB from Mycobacterium tuberculosis Fulltext Access 11 Pages 2006
Crystal Structure of Group A Streptococcus Mac-1: Insight into Dimer-Mediated Specificity for Recognition of Human IgG Fulltext Access 11 Pages 2006
The Crystal Structure of Aspergillus fumigatus Cyclophilin Reveals 3D Domain Swapping of a Central Element Fulltext Access 11 Pages 2006
Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma Fulltext Access 11 Pages 2006
Oxygen binding and NO scavenging properties of truncated hemoglobin, HbN, of Mycobacterium smegmatis Fulltext Access 11 Pages 2006
Functional dissection of human protease μ-calpain in cell migration using RNAi Fulltext Access 11 Pages 2006
Correlation between genomic DNA copy number alterations and transcriptional expression in hepatitis B virus-associated hepatocellular carcinoma Fulltext Access 11 Pages 2006
Cancer-selective induction of cytotoxicity by tissue-specific expression of targeted trans-splicing ribozyme Fulltext Access 11 Pages 2006
Trace amounts of copper induce neurotoxicity in the cholesterol-fed mice through apoptosis Fulltext Access 11 Pages 2006
Altered β-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer’s disease brain Fulltext Access 11 Pages 2006
Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing Fulltext Access 11 Pages 2006
The multidrug resistance-associated protein (MRP/ABCC) subfamily of ATP-binding cassette transporters in plants Fulltext Access 11 Pages 2006
The Tie2 5′ untranslated region is inhibitory to 5′ end-mediated translation initiation Fulltext Access 11 Pages 2006
Transcriptional autoregulation by Mycobacterium tuberculosis PhoP involves recognition of novel direct repeat sequences in the regulatory region of the promoter Fulltext Access 11 Pages 2006
Structure of the Catalytic and Ubiquitin-Associated Domains of the Protein Kinase MARK/Par-1 Fulltext Access 11 Pages 2006
Epidermal sphingolipids: Metabolism, function, and roles in skin disorders Fulltext Access 11 Pages 2006
A Receptor-Modifying Deamidase in Complex with a Signaling Phosphatase Reveals Reciprocal Regulation Fulltext Access 11 Pages 2006
A Three-Protein Signaling Pathway Governing Immunity to a Bacterial Cannibalism Toxin Fulltext Access 11 Pages 2006
Structural Basis for Cooperativity in Recruitment of MAML Coactivators to Notch Transcription Complexes Fulltext Access 11 Pages 2006
A Segmentation Gene in Tribolium Produces a Polycistronic mRNA that Codes for Multiple Conserved Peptides Fulltext Access 11 Pages 2006
A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for ER-Associated Degradation Fulltext Access 11 Pages 2006
A Molecular Mousetrap Determines Polarity of Termination of DNA Replication in E. coli Fulltext Access 11 Pages 2006
Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network Fulltext Access 11 Pages 2006
Microbubble-enhanced ultrasound to deliver an antisense oligodeoxynucleotide targeting the human androgen receptor into prostate tumours Fulltext Access 11 Pages 2006
Developing functional magnetic resonance imaging techniques for alert macaque monkeys Fulltext Access 11 Pages 2006
Analysis of mitogen-activated protein kinase activation and interactions with regulators and substrates Fulltext Access 11 Pages 2006
Hormonal effects on the secretion and glycoform profile of corticosteroid-binding globulin Fulltext Access 11 Pages 2006
Identification of estrogen receptor ligands leading to activation of non-genomic signaling pathways while exhibiting only weak transcriptional activity Fulltext Access 11 Pages 2006
Targeted mutation of key residues at the start of helix 12 in the hERα ligand-binding domain identifies the role of hydrogen-bonding and hydrophobic interactions in the activity of the protein Fulltext Access 11 Pages 2006
Activation of kinase pathways in MCF-7 cells by 17β-estradiol and structurally diverse estrogenic compounds Fulltext Access 11 Pages 2006
Identification of covalent attachment site of antiestrogenic estradiol 11β-derivatives on human estrogen receptor α ligand-binding domain Fulltext Access 11 Pages 2006
Increased expression of α- and β-globin mRNAs at the pituitary following exposure to estrogen during the critical period of neonatal sex differentiation in the rat Fulltext Access 11 Pages 2006
Emerging principles for the development of resistance to antihormonal therapy: Implications for the clinical utility of fulvestrant Fulltext Access 11 Pages 2006
Combinatorial effects of the phytoestrogen genistein and of estradiol in uterus and liver of female Wistar rats Fulltext Access 11 Pages 2006
Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification Fulltext Access 11 Pages 2006
Comparison of effects of 4-hydroxy tamoxifen and trilostane on oestrogen-regulated gene expression in MCF-7 cells: Up-regulation of oestrogen receptor beta Fulltext Access 11 Pages 2006
Tissue-cell- and species-specific expression of gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) in gonads, adrenal and brain Fulltext Access 11 Pages 2006
Rational proteomics V: Structure-based mutagenesis has revealed key residues responsible for substrate recognition and catalysis by the dehydrogenase and isomerase activities in human 3β-hydroxysteroid dehydrogenase/isomerase type 1 Fulltext Access 11 Pages 2006
Other conceivable renditions of some of the oxidative processes used in the biosynthesis of steroid hormones Fulltext Access 11 Pages 2006
Development of a mouse model of mammary gland versus uterus tissue selectivity using estrogen- and progesterone-regulated gene markers Fulltext Access 11 Pages 2006
Purification and biochemical characterization of a fibroblast growth factor-binding protein (FGF-BP) from the lactoferrin fraction of bovine milk Fulltext Access 11 Pages 2006
Intracellular conformational alterations of mutant SOD1 and the implications for fALS-associated SOD1 mutant induced motor neuron cell death Fulltext Access 11 Pages 2006
Deviation of carbohydrate metabolism by the SIT4 phosphatase in Saccharomyces cerevisiae Fulltext Access 11 Pages 2006
CLA isomers inhibit TNFα-induced eicosanoid release from human vascular smooth muscle cells via a PPARγ ligand-like action Fulltext Access 11 Pages 2006
The Ig Doublet Z1Z2: A Model System for the Hybrid Analysis of Conformational Dynamics in Ig Tandems from Titin Fulltext Access 11 Pages 2006
FeeM, an N-Acyl Amino Acid Synthase from an Uncultured Soil Microbe: Structure, Mechanism, and Acyl Carrier Protein Binding Fulltext Access 11 Pages 2006
“Similarity Trap” in Protein-Protein Interactions Could Be Carcinogenic: Simulations of p53 Core Domain Complexed with 53BP1 and BRCA1 BRCT Domains Fulltext Access 11 Pages 2006
Electron Transfer Complex Formation between Oxygenase and Ferredoxin Components in Rieske Nonheme Iron Oxygenase System Fulltext Access 11 Pages 2006
Stability and Dynamics of Virus Capsids Described by Coarse-Grained Modeling Fulltext Access 11 Pages 2006
Structural Insights into the Specific Binding of Huntingtin Proline-Rich Region with the SH3 and WW Domains Fulltext Access 11 Pages 2006
Cytotoxic biotransformed products from cinobufagin by Mucor spinosus and Aspergillus Niger Fulltext Access 11 Pages 2006
Synthesis of unique 17β-estradiol homo-dimers, estrogen receptors binding affinity evaluation and cytocidal activity on breast, intestinal and skin cancer cell lines Fulltext Access 11 Pages 2006
Novel 5β-hydroxyspirostan-6-ones ecdysteroid antagonists: Synthesis and biological testing Fulltext Access 11 Pages 2006
Oxidant/antioxidant interactions of nicotine, Coenzyme Q10, Pycnogenol and phytoestrogens in oral periosteal fibroblasts and MG63 osteoblasts Fulltext Access 11 Pages 2006
The spirostenol (22R, 25R)-20α-spirost-5-en-3β-yl hexanoate blocks mitochondrial uptake of Aβ in neuronal cells and prevents Aβ-induced impairment of mitochondrial function Fulltext Access 11 Pages 2006
Detection and quantification of glucuro- and sulfoconjugated metabolites in human urine following oral administration of xenobiotic 19-norsteroids Fulltext Access 11 Pages 2006
Ionic interventions that alter the association of troponin C C-domain with the thin filaments of vertebrate striated muscle Fulltext Access 11 Pages 2006
Intracellular cytokine staining for the characterization and quantitation of antigen-specific T lymphocyte responses Fulltext Access 11 Pages 2006