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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Controlled phase separations in solutions of polyelectrolyte complexes Potential for gene delivery
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Effect of hawthorn (Crataegus oxycantha) crude extract and chromatographic fractions on multiple activities in a cultured cardiomyocyte assay
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Native Kenyan plants as possible alternatives to methyl bromide in soil fumigation
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Antihyperglycemic activity of Tarralin™, an ethanolic extract of Artemisia dracunculus L.
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Safety of ethanolic kava extract: Results of a study of chronic toxicity in rats
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Protective effects of Rosmarinus tomentosus ethanol extract on thioacetamide-induced liver cirrhosis in rats
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Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells
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Influence of liposome composition on in vitro permeation of diosmin through human stratum corneum and epidermis
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Quantitative assessment of tissue retention, lipophilicity, ionic valence and convective transport of permeant as factors affecting iontophoretic enhancement
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pH-sensitive hydrogel based on a polyaspartamide derivative
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Stimuli-sensitive protein delivery systems
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Properties of various thermoassociating polymers: pharmaceutical and cosmetic applications
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A comparative study of collagenase complex and new homogeneous collagenase preparations for scar treatment
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Electrophysiological effects of the aqueous extract of Averrhoa carambola L. leaves on the guinea pig heart
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Formulation and stability of rofecoxib suppositories
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Lysozyme-containing chitosan-coated alginate microspheres for oral immunisation
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Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution
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Insulin in flavin-containing monooxygenase regulation: Flavin-containing monooxygenase and cytochrome P450 activities in experimental diabetes
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PAMPA—A drug absorption in vitro model : 13. Chemical selectivity due to membrane hydrogen bonding: In combo comparisons of HDM-, DOPC-, and DS-PAMPA models
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Evaluation of 5-aminosalicyltaurine as a colon-specific prodrug of 5-aminosalicylic acid for treatment of experimental colitis
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Solubilization behavior of a poorly soluble drug under combined use of surfactants and cosolvents
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Drug permeability across a phospholipid vesicle-based barrier: 2. Characterization of barrier structure, storage stability and stability towards pH changes
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Permeability and swelling studies on free films containing inulin in combination with different polymethacrylates aimed for colonic drug delivery
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Paclitaxel modifies the accumulation of tumor-diagnostic tracers in different ways in P-glycoprotein-positive and negative cancer cells
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Luminal delivery and dosing considerations of local celecoxib administration to colorectal cancer
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The synthesis of heterocyclic derivatives from pyran-2-ones and hydrazine hydrate. Ammonium cerium(IV) nitrate as an efficient oxidant in pyridazine chemistry
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Graphical contents list
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One-pot conversion of activated alcohols into 1,1-dibromoalkenes and terminal alkynes using tandem oxidation processes with manganese dioxide
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Tetrahedron reports on organic chemistry author index
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Novel formation of 1,3-oxazepine heterocycles via palladium-catalyzed intramolecular coupling reaction
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Synthesis of conformationally diverse tetrathiacalix[4]arene(amido)crowns and tetrathiacalix[4]arene amides with pendant amine functions
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A novel conversion of acetylenic 1,2,4-triazoles into 3-alkyl-5-arylpyridazines
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Asymmetric cycloaddition reactions between 2-benzopyrylium-4-olates and 3-(2-alkenoyl)-2-oxazolidinones in the presence of 2,6-bis(oxazolinyl)pyridine-lanthanoid complexes
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Diastereoselective alkylation of iminomethylenephosphinates possessing an asymmetric center at the phosphorus atom
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Convergent synthesis of PAMAM dendrimers using click chemistry of azide-functionalized PAMAM dendrons
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Synthesis of enantiopure cis-decahydroquinolines from homotyramines by Birch reduction and aminocyclization
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Ten new antifouling briarane diterpenoids from the South China Sea gorgonian Junceella juncea
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Palladium-catalyzed reactions of vinylidenecyclopropanes with acetic acid
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Assessment of transport rates of proteins and peptides across primary human alveolar epithelial cell monolayers
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On the mechanism of conversion of 4-carboxy-3,4-dihydro-3-phenyl-1(2H)-isoquinolones to indeno[1,2-c]isoquinolines by thionyl chloride
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Solid-phase synthesis of backbone-cyclized β-helical peptides
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Shorter puromycin analog synthesis by means of an efficient Staudinger-Vilarrasa coupling
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Synthesis of 1,4-diaza-7-oxabicyclo[4.3.0]non-2-en-6-ones by cyclization of 1,1-bis(trimethylsiloxy)ketene acetals with pyrazine and quinoxaline
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Protective effect of CardiPro against doxorubicin-induced cardiotoxicity in mice
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Structure–activity relations of inhibitory effects of various flavonoids on lipopolysaccharide-induced prostaglandin E2 production in rat peritoneal macrophages: Comparison between subclasses of flavonoids
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In vitro glucose uptake activity of Aegles marmelos and Syzygium cumini by activation of Glut-4, PI3 kinase and PPARγ in L6 myotubes
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Multitarget therapy – The future of treatment for more than just functional dyspepsia
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Phytotherapy for functional dyspepsia: A review of the clinical evidence for the herbal preparation STW 5
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Spasmolytic and tonic effect of Iberogast® (STW 5) in intestinal smooth muscle
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Pharmaceutical prerequisites for a multi-target therapy
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In vitro evaluation of herpes simplex virus type 1 thymidine kinase reporter system in dynamic studies of transcriptional gene regulation
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Ischemia/Reperfusion Injury in the Monolayers of Human Intestinal Epithelial Cell Line Caco-2 and Its Recovery by Antioxidants
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Excellent Absorption Enhancing Characteristics of NO Donors for Improving the Intestinal Absorption of Poorly Absorbable Compound Compared with Conventional Absorption Enhancers
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Characterization of Prostaglandin E1 Transport in Rat Renal Brush-border Membrane
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Population Pharmacokinetic Analysis of Micafungin in Japanese Patients with Fungal Infections
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Fourteen Novel Genetic Variations and Haplotype Structures of the TYMS Gene Encoding Human Thymidylate Synthase (TS)
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In vitro and in vivo characterization of 177Lu-huA33: A radioimmunoconjugate against colorectal cancer
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Effect of hypoxia on the uptake of [methyl-3H]choline, [1-14C] acetate and [18F]FDG in cultured prostate cancer cells
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[99mTc]HYNIC-RGD for imaging integrin αvβ3 expression
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Dual-expressing adenoviral vectors encoding the sodium iodide symporter for use in noninvasive radiological imaging of therapeutic gene transfer
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Synthesis and evaluation of a radiometal-labeled macrocyclic chelator-derivatised thymidine analog
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Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic study
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O-(2-[18F]fluoroethyl)-l-tyrosine: uptake mechanisms and clinical applications
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Characterization of Intestinal Absorption and Enterohepatic Circulation of Mycophenolic Acid and Its 7-O-Glucuronide in Rats
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Comparison of [18F]FDOPA, [18F]FMT and [18F]FECNT for imaging dopaminergic neurotransmission in mice
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Alkyl-fluorinated thymidine derivatives for imaging cell proliferation: II. Synthesis and evaluation of N3-(2-[18F]fluoroethyl)-thymidine
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Double-tracer autoradiography with Cu-ATSM/FDG and immunohistochemical interpretation in four different mouse implanted tumor models
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A 99mTc-labeled gemcitabine bisphosphonate drug conjugate as a probe to assess the potential for targeted chemotherapy of metastatic bone cancer
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[11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia
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Rhemium-186-monoaminemonoamidedithiol-conjugated bisphosphonate derivatives for bone pain palliation
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Radionuclide imaging of small-cell lung cancer (SCLC) using 99mTc-labeled neurotensin peptide 8–13
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In vitro and in vivo evaluation of 177Lu- and 90Y-labeled E. coli heat-stable enterotoxin for specific targeting of uroguanylin receptors on human colon cancers
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Binding properties of the cerebral α4β2 nicotinic acetylcholine receptor ligand 2-[18F]fluoro-A-85380 to plasma proteins
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Metabolism of the A1 adenosine receptor PET ligand [18F]CPFPX by CYP1A2: implications for bolus/infusion PET studies
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Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line
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In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer
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Design and in vitro performance testing of multiple air classifier technology in a new disposable inhaler concept (Twincer®) for high powder doses
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The determination of relative path length as a measure for tortuosity in compacts using image analysis
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Polymorphism and thermodynamics of m-hydroxybenzoic acid
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Particle swarm algorithm trained neural network for QSAR studies of inhibitors of platelet-derived growth factor receptor phosphorylation
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Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols
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Biorelevant dissolution media as a predictive tool for glyburide a class II drug
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Genetic polymorphisms of cytochrome P450 2B6 gene in Han Chinese
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Instructions to Authors
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A level A in vitro/in vivo correlation in fasted and fed states using different methods: Applied to solid immediate release oral dosage form
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Pharmacogenetics of cyclophosphamide in patients with hematological malignancies
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The effect of crystal morphology and mill type on milling induced crystal disorder
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Gastrointestinal transit and disintegration of enteric coated magnetic tablets assessed by ac biosusceptometry
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Synthesis and evaluation of a bromine-76-labeled PPARγ antagonist 2-bromo-5-nitro-N-phenylbenzamide
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Structure elucidation of the tetrahydrocannabinol complex with randomly methylated β-cyclodextrin
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Bidirectional membrane transport: Simulations of transport inhibition in uptake studies explain data obtained with flavonoids
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Development and evaluation of an in vitro method for prediction of human drug absorption: I. Assessment of artificial membrane composition
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Modulation of the rheological and mucoadhesive properties of thermosensitive poloxamer-based hydrogels intended for the rectal administration of quinine
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Effect of trimetazidine on the nucleotide profile in rat kidney with ischemia–reperfusion injury
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Dry coating in a rotary fluid bed
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Interactions between the dopamine agonist, bromocriptine and the efflux protein, P-glycoprotein at the blood–brain barrier in the mouse
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The difference between partitioning and distribution from a thermodynamic point of view: NSAIDs as an example
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Biodegradable thermo-sensitive nanoparticles from poly(l-lactic acid)/poly(ethylene glycol) alternating multi-block copolymer for potential anti-cancer drug carrier
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Pharmacokinetic Analysis of the Uptake of Liposomes by Macrophages and Foam Cells In Vitro and their Distribution to Atherosclerotic Lesions in Mice
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Regulation of Mouse Hepatic CYP2D9 mRNA Expression by Growth and Adrenal Hormones
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