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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Microwave-assisted one-pot U-4CR and intramolecular O-alkylation toward heterocyclic scaffolds
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One-pot regioselective annulation toward 3,4-dihydro-3-oxo-2H-1,4-benzoxazine scaffolds under controlled microwave heating
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Regioselective arylation of 2′-deoxyribonucleosides on amido or imino sites by copper(II)-mediated direct coupling with arylboronic acids
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Use of zinc enolate, free from other metals, in enantioselective palladium-catalyzed allylic alkylation
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Heteroarenium salts in synthesis. Highly functionalized tetra- and pentasubstituted pyridines
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Graphical contents list
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Synthesis of (tetrahydrofuran-2-yl)acetates based on a 'cyclization/hydrogenation/enzymatic kinetic resolution' strategy
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Direct synthesis of tetrahydropyrans via one-pot Babier-Prins cyclization of allylbromide with carbonyl compounds promoted by RTILs BPyX/SnX′2 or BBIMBr/SnBr2
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Synthesis of short and long chain cardiolipins
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'Two-point'-bound supramolecular complexes from semi-rigidified dipyridine receptors and zinc porphyrins
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Synthesis of coumarins by Pt-catalyzed hydroarylation of propiolic acids with phenols
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Leishmanicidal activity of withajardins and acnistins. An experimental and computational study
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Diarylethenes with intramolecular donor-acceptor structures for photo-induced electrochemical change
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Microwave-assisted regioselective olefinations of cyclic mono- and di-ketones with a stabilized phosphorus ylide
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A way to manage the thermal flexibility of ligand candidates for bioassays
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Efficient synthesis of 2,5-diketopiperazines using microwave assisted heating
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Application of the photocyclization reaction of 1,2-cyclopenta-fused pyridinium perchlorate to formal total syntheses of (−)-cephalotaxine
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A nickel(0) catalyzed cycloaddition of alkynes and isocyanates that affords pyrimidine-diones
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Synthesis of enantiopure 1-substituted, 1,2-disubstituted, and 1,4,5-trisubstituted imidazoles from 1,2-amino alcohols
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Total synthesis of (+)-massarinolin B and (+)-4-epi-massarinolin B, fungal metabolites from Massarina tunicata
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Diastereoselective Michael addition of (S)-mandelic acid enolate to 2-arylidene-1,3-diketones: enantioselective diversity-oriented synthesis of densely substituted pyrazoles
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Indirect electrochemical oxidation of piperidin-4-ones mediated by sodium halide-base system
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Synthesis of peptidomimetic-spirostane hybrids via Ugi reaction: a versatile approach for the formation of peptide-steroid conjugates
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Selective syntheses of benzoxazoles and N-(2-hydroxyaryl)pyrrolidin-2-ones from the corresponding cyclopropyl amides with PPh3/CX4
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Synthesis of substituted 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine as new scaffolds for potential bioactive compounds
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Synthesis of the heterocyclic core of martinelline and martinellic acid
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The first total synthesis of (R)-convolutamydine A
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Sequential Baylis-Hillman reaction and radical cyclization of furanose derivatives: expeditious approach to enantiopure benzo-fused nine-membered oxacycles
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On the reactivity of 2-alkyl-1,3-thiazolium-4-olates toward electrophiles
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Oxobenzo[f]benzopyrans as new fluorescent photolabile protecting groups for the carboxylic function
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Chemoselective hydrogenation method catalyzed by Pd/C using diphenylsulfide as a reasonable catalyst poison
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A convenient preparation of thioether functionalized porphyrins
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Catalytic imino Diels-Alder reaction by triflic imide and its application to one-pot synthesis from three components
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New cytotoxic sesquiterpenes from the red algae Laurencia obtusa and Laurencia microcladia
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PEG-400 promoted Pd(OAc)2/DABCO-catalyzed cross-coupling reactions in aqueous media
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Ground state oxygen in synthesis of cyclic peroxides. Part 1: Benzo fused ketals
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Chemistry of dioxine-annelated cycloheptatriene endoperoxides and their conversion into tropolone derivatives: an unusual non-benzenoid singlet oxygen source
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Stereoselective electrocatalytic transformation of malonate and alkylidenecyanoacetates into (E)-3-substituted 2-cyanocyclopropane-1,1,2-tricarboxylates
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Synthesis of analogs of the phenylamino-pyrimidine type protein kinase C inhibitor CGP 60474 utilizing a Negishi cross-coupling strategy
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Synthesis of stereochemical probes for new fluorogenic assays for yeast transketolase variants
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Asymmetric Diels-Alder reactions with hydrogen bonding heterogeneous catalysts and mechanistic studies on the reversal of enantioselectivity
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α-Amido sulfones from natural α-amino acids and their reaction with carbon nucleophiles
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Callipeltins F-I: new antifungal peptides from the marine sponge Latrunculia sp.
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Graphical contents list
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Cycloadditions of α-(4-[2.2]paracyclophanyl)-N-methyl nitrone
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The role of F-N reagent and reaction conditions on fluoro functionalisation of substituted phenols
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Studies on pyrrolidinones. Oxidations and rearrangements in the hexahydrobenz[f]indolizine-3,10-dione series
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Ring expansion of 11H-benzo[b]fluorene-11-methanols and related compounds leading to 17,18-diphenyldibenzo[a,o]pentaphene and related polycyclic aromatic hydrocarbons with extended conjugation and novel architectures
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Chiral recognition of protected amino acids by means of fluorescent binary complex pyrene/heptakis-(6-amino)-(6-deoxy)-β-cyclodextrin
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The mercury-mediated decarboxylation (Pesci reaction) of naphthoic anhydrides investigated by microwave synthesis
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Syntheses of highly functionalized δ,γ-unsaturated-α-amino acids
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Metallo-phosphorylation of alkenes: a highly regioselective reaction of zirconocene-alkene complexes with chlorophosphate
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Stereoselective total synthesis of (±)-α-vetispirene, (±)-hinesol, and (±)-β-vetivone based on a Claisen rearrangement
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Efficient halogen-lithium exchange reactions to functionalize poly(alkyl aryl ether) dendrimers
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Comparative studies for selective deprotection of the N-arylideneamino moiety from heterocyclic amides: kinetic and theoretical studies. Part 2
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Intramolecular cyclisation of functionalised heteroaryllithiums. Synthesis of novel indolizinone-based compounds
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Reaction of singlet oxygen with some benzylic sulfides
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Auxiliary controlled singlet-oxygen ene reactions of cyclohexenes
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Singlet oxygen addition to chiral allylic alcohols and subsequent peroxyacetalization with β-naphthaldehyde: synthesis of diastereomerically pure 3-β-naphthyl-substituted 1,2,4-trioxanes
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Synthesis of novel spiro-cyclohexene bicyclo[2.2.2]octane derivatives
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New cytotoxic cembranolides: isolation, biogenetic studies, and synthesis of analogues
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Regio- and diastereoselective functionalization of (−)-cytisine
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A facile access to bridged 1,2,4-trioxanes
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Operationally convenient, efficient asymmetric synthesis of enantiomerically pure 4-aminoglutamic acids via methylene dimerization of chiral glycine equivalents with dichloromethane
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Preparation of optically pure fused polycyclic scaffolds by Ugi reaction followed by olefin and enyne metathesis
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Nitroso group transfer from N-nitrososulfonamides to thiolate ions. Intrinsic reactivity
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Carbenoid rearrangement of gem-dihalogenospiropentanes
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(4R)-4-Hydroxy-1-nitroso-l-proline: synthesis, X-ray structure, ab initio and conformational calculations
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An alternate approach to quinoline architecture via Baylis-Hillman chemistry: SnCl2-mediated tandem reaction toward synthesis of 4-(substituted vinyl)-quinolines
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Syntheses of metabolites of ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603)
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The use of (−)-8-phenylisoneomenthol and (−)-8-phenylmenthol in the enantioselective synthesis of 3-functionalized 2-azabicyclo[2.2.1]heptane derivatives via aza-Diels-Alder reaction
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Highly regioselective [3,3] rearrangement of aliphatic allyl vinyl ethers catalyzed by a metalloporphyrin complex, Cr(TPP)Cl
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The novel reaction of ketones with o-oxazoline-substituted anilines
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Synthesis of dispirooxindolecycloalka[d]pyrimidino[2,3-b]-thiazole pyrrolidine/thiapyrrolizidine ring systems
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Silver(I) complexes based on novel tripodal thioglycosides: synthesis, structure and antimicrobial activity
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Biocatalytic preparation of enantioenriched 3,4-dihydroxypiperidines and theoretical study of Candida antarctica lipase B enantioselectivity
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Novel annulated products from aminonaphthyridinones
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Synthesis of functionalized analogs of pyochelin, a siderophore of Pseudomonas aeruginosa and Burkholderia cepacia
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The synthesis and reaction of N-sulfenyl heterocycles: development of effective sulfenylating reagents
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Phloroglucinols, depsidones and xanthones from the twigs of Garcinia parvifolia
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Optically pure trans-2,3-disubstituted N-sulfinyl aziridines. Regio- and stereoselective opening mediated by the sulfinyl group
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Five new isocoumarins from Sonoran desert plant-associated fungal strains Paraphaeosphaeria quadriseptata and Chaetomium chiversii
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Graphical contents list
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Functionalized thiacalix- and calix[4]arene-based Ag+ ionophores: synthesis and comparative NMR study
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Synthesis of β-amino carbonyl compounds via a Zn(OTf)2-catalyzed cascade reaction of anilines with aromatic aldehydes and carbonyl compounds
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Graphical contents list
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Regioselectivity in the formation of norbornene-fused pyrazoles: preparation of 1-substituted derivatives of 4,5,6,7-tetrahydro-1H-4,7-methanoindazole
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First cross-coupling reactions on halogenated 1H-1,2,4-triazole nucleosides
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Graphical contents list
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Graphical contents list
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Application of the combined C-H activation/Cope rearrangement as a key step in the total syntheses of the assigned structure of (+)-elisabethadione and a (+)-p-benzoquinone natural product
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Tetrahedron reports on organic chemistry author index
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Synthesis and reactions of nitro derivatives of hydrogenated cardanol
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Calix[4]quinones. Part 4: The ClO2 oxidation of calix[4]arene dialkyl ethers
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Fluorescent imidazolium receptors for the recognition of pyrophosphate
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A general and efficient method for the copper-catalyzed cross-coupling of amides and thiophenols with 6-halogenoimidazo[1,2-a]pyridines
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Unique chlorine effect in regioselective one-pot synthesis of 1-alkyl-/allyl-3-(o-chlorobenzyl) uracils: anti-HIV activity of selected uracil derivatives
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Regiospecific and enantioselective synthesis of methylated metabolites of tea catechins
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Reactions of salicyl N-tosylimines or salicylaldehydes with diethyl acetylenedicarboxylate for the synthesis of highly functionalized chromenes
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Pseudoguaiane-type sesquiterpenes and inhibitors on nitric oxide production from Dichrocephala integrifolia
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