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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Highly efficient resolutions of 1,4-benzodioxane-2-carboxylic acid with para substituted 1-phenylethylamines
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A stereoselective approach to phosphodiester-linked oligomers of the repeating unit of Escherichia coli K52 capsular polysaccharide containing β-D-fructofuranosyl moieties
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Tetra- and penta-fructooligosaccharide (FOS) isomers assessment in onion bulb tissues: effect of temperature and storage time
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Versatile synthesis of oligosaccharide-containing fullerenes
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Chemoenzymatic syntheses of new optically active C2-symmetrical macrocyclic polyazacyclophanes
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A short and convenient chemoenzymatic synthesis of both enantiomers of 3-phenylGABA and 3-(4-chlorophenyl)GABA (Baclofen)
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PdII-Catalyzed stereospecific formation of tetrahydro- and 3,6-dihydro[2H]pyran rings: 1,3-chirality transfer by intramolecular oxypalladation reaction
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Graphical contents list
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Diastereomeric phosphite-pyridine ligands for enantioselective 1,4-conjugate additions
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Enzyme-catalyzed preparation of methyl (R)-N-(2,6-dimethylphenyl)alaninate: a key intermediate for (R)-metalaxyl
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Asymmetric palladium-catalyzed benzylic nucleophilic substitution: high enantioselectivity with the DUPHOS family ligands
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Stereoselective Lewis acid promoted Kharasch-type addition of 3-bromoacetyl-2-oxazolidinones to norbornadiene
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Enzymatic resolution of sec-butylamine
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Resolution of (+)-abscisic acid using an Arabidopsis glycosyltransferase
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The stereocontrolled synthesis of polyfunctional organosulfur compounds via chiral azetidinium salts and epoxyamines
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Cumulative author index
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Determination of the enantiomeric composition of ibuprofen solutions via a rapid and sensitive mass spectrometry method
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A facile and convenient chemoenzymatic synthesis of optically active O-(4-methoxyphenyl)-glycidol and 1,2-diacyl-sn-glycerol
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Enantioselective Pd-catalyzed C*-C, C*-N, and C*-S bond formation reactions using first P,P,N,N-tetradentate chiral phosphites
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Sesquiterpene constituents of the liverwort Lophozia ventricosa
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α-Hydroxy carboxylic acids as ligands for enantioselective addition reactions of organoaluminum reagents to aromatic and aliphatic aldehydes
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Enhanced enantioselectivity of Bacillus coagulans in the hydrolysis of 1,2-O-isopropylidene glycerol esters by thermal knock-out of undesired enzymes
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Total synthesis of (+)-(S)-angustureine and the determination of the absolute configuration of the natural product angustureine
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Electron transfer in N-hydroxyurea complexes with iron(III)
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Synthesis of Schiff bases of 4-(4-aminophenyl)-morpholine as potential antimicrobial agents
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Catalytic asymmetric induction of planar chirality: palladium catalyzed intramolecular Mizoroki-Heck reaction of prochiral (arene)chromium complexes
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6′-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the α4β2 nicotinic receptor pharmacophore model
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Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2
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Glycosylation of glycopeptides: a comparison of chemoenzymatic and chemical methods
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Synthesis of differentially protected ribitol derivatives from 3,4-O-benzylidene-d-ribono-1,5-lactone
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Synthesis of a trihydroxylated azepane from d-arabinose by way of an intramolecular alkene nitrone cycloaddition
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Microwave-assisted C-H bond activation using a commercial microwave oven for rapid deuterium exchange labeling (C-H → C-D) in carbohydrates
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Glyco-quantum dots: a new luminescent system with multivalent carbohydrate display
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Thiomidoyl approach to the synthesis of α-sialosides
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Stereoselective glycosylation of exo-glycals by microwave-assisted Ferrier rearrangement
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Kinetic resolution of 5-(hydroxymethyl)-3-phenyl-2-isoxazoline by using the 'low-temperature method' with porous ceramic-immobilized lipase
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Selectivity of Daucus carota roots and baker's yeast in the enantioselective reduction of γ-nitroketones
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Screening yeasts for the stereoselective reduction of oxoester clofibrate analogues
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Towards a model for the inhibition of choline kinase by a new type of inhibitor
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Convenient preparation of optically active N,N-bis(4-substituted-4-aminobutyl)amines
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Chiral C2-symmetric ligands containing two binaphthyl units linked by 2,2′-bipyridyl bridge in asymmetric catalysis
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Asymmetric hydrogenation of chiral vinyloxazaborolidines under ambient conditions
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Chemoenzymatic synthesis of ketomethylene tripeptide isosteres
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Monophosphite ligands derived from carbohydrates and H8-BINOL: highly enantioselective Rh-catalyzed asymmetric hydrogenations
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Asymmetric synthesis of α-sulfinylphosphonates in the thiolane series
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Preparation of enantiopure inherently chiral calix[5]arenes
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First synthesis of 4,5-O-isopropylidene-6-thio-d-galactono-1,6-lactone as a precursor of d-galactothioseptanose
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Furanoside thioether-phosphinite ligands for Pd-catalyzed asymmetric allylic substitution reactions
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Stereoselective synthesis of (2S,7S)-7-(4-phenoxymethyl)-2-(1-N-hydroxyureidyl-3-butyn-4-yl)oxepane: a potential anti-asthmatic drug candidate
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Enantioselective addition of organolithium reagents to quinoline catalyzed by 1,2-diamines
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Catalytic Pictet–Spengler reactions using Yb(OTf)3
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Graphical contents list
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New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human κ opioid receptors
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Graphical contents list
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Instructions to contributors
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Mechanism of proliferation arrest of embryonic cells of Xenopus by diterpene compounds
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Regioselective synthesis of cyclodextrin mono-substituted conjugates of non-steroidal anti-inflammatory drugs at C-2 secondary hydroxyl by protease in non-aqueous media
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Four diterpenoid inhibitors of Cdc25B phosphatase from a marine anemone
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Identification of caffeoylquinic acid derivatives from Brazilian propolis as constituents involved in induction of granulocytic differentiation of HL-60 cells
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Synthesis and antimycobacterial evaluation of various 7-substituted ciprofloxacin derivatives
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Carbonic anhydrase inhibitors: Inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides
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Imaging amyloid β peptide oligomeric particles in solution
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Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion
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Tetrabutylammonium fluoride-assisted rapid N9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ
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Ladder-shaped polyether compound, desulfated yessotoxin, interacts with membrane-integral α-helix peptides
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Sesterterpenoids and an alkaloid from a Thorectandra sp. as inhibitors of the phosphatase Cdc25B
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Water-soluble chitosan derivatives as a BACE1 inhibitor
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A proposed molecular basis for the selective resveratrol inhibition of the PGHS-1 peroxidase activity
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Solution conformations of two naturally occurring RNA nucleosides: 3-Methyluridine and 3-methylpseudouridine
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A synthetic approach to the generation of quercetin sulfates and the detection of quercetin 3′-O-sulfate as a urinary metabolite in the rat
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Synthesis and biological activity of N-methylated analogs of endomorphin-2
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Instructions to contributors
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Synthesis, immunological activities, and scavenging ability toward superoxide anion of (1→3)-β-d-pentaglucoside and its epoxyalkyl derivatives
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An efficient, stereoselective synthesis of (−)-bulgecinine from (S)-aspartic acid
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Enantioselective esterase activity of an industrial glutaryl acylase
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Instructions to contributors
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Antibacterial and antifungal activities of new pyrazolo[3,4-d]pyridazin derivatives
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Antileishmanial agents part-IV: synthesis and antileishmanial activity of novel terpenyl pyrimidines
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Synthesis, spectroscopic and biological properties of bis(3-arylimidazolidinyl-1)methanes. A novel family of antimicrobial agents
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A quantum chemical and statistical study of ganoderic acids with cytotoxicity against tumor cell
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Dendrimers as Potential Drug Carriers. Part I. Solubilization of Non-Steroidal Anti-Inflammatory Drugs in the Presence of Polyamidoamine Dendrimers
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One pot synthesis of oxygenated tri-heterocycles as anti-microbial agents
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3,4-trans-4-Aryl-3-(1-pyridinio)-1,2,3,4-tetrahydropyridine-6-thiolates-new group of potential cardiotonic drugs
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Synthesis and Biological Activity of Novel Acridinylidene and Benzylidene thiazolidinediones
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Index des auteurs
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Synthesis and in vitro leishmanicidal activity of 2-(1-methyl-5-nitro-1H-imidazol-2-yl)-5-substituted-1,3,4-thiadiazole derivatives
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The molecular mechanisms involved in the cytotoxicity of alkannin derivatives
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Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs)
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Improved synthesis of enantiopure pseudo-C2-symmetric 1,4-bis-epoxide building blocks from arabitol
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Instructions to contributors
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Mild and efficient oxidation of alcohols with sodium periodate catalyzed by polystyrene-bound Mn(III)porphyrin
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Instructions to contributors
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Synthesis of DEHP metabolites as biomarkers for GC–MS evaluation of phthalates as endocrine disrupters
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Instructions to contributors
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A prenylbisabolane with NF-κB inhibiting properties from Cascarilla (Croton eluteria)
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Graphical contents list
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Instructions to contributors
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Enzymatic hydrolysis of stampidine and other stavudine phosphoramidates in the presence of mammalian proteases
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Instructions to contributors
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Theoretical analysis of the retention behavior of alcohols in gas chromatography
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