A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells Fulltext Access 5 Pages 2005
Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: Discovery of potent S1P1 receptor agonists Fulltext Access 5 Pages 2005
Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors Fulltext Access 5 Pages 2005
Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase Fulltext Access 5 Pages 2005
Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1 Fulltext Access 5 Pages 2005
Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subt Fulltext Access 5 Pages 2005
Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles Fulltext Access 5 Pages 2005
Minor structural modifications convert a selective PPARα agonist into a potent, highly selective PPARδ agonist Fulltext Access 5 Pages 2005
Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists Fulltext Access 5 Pages 2005
Design, synthesis, and structure–activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis Fulltext Access 5 Pages 2005
Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists Fulltext Access 5 Pages 2005
Screening of active compounds as neuromedin U2 receptor agonist from natural products Fulltext Access 5 Pages 2005
An efficient synthesis of aryloxyphenyl cyclopropyl methanones: a new class of anti-mycobacterial agents Fulltext Access 5 Pages 2005
Hepatitis C virus NS3-4A serine protease inhibitors: Use of a P2–P1 cyclopropyl alanine combination for improved potency Fulltext Access 5 Pages 2005
Facile synthesis and PET imaging of a novel potential heart acetylcholinesterase tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2â²,2â²-diphenylpropionoxymethyl)pyridinium Fulltext Access 5 Pages 2005
Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives Fulltext Access 5 Pages 2005
Synthesis and cytotoxic activity of platinum complex immobilized by branched polyethylene glycol Fulltext Access 5 Pages 2005
Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors Fulltext Access 5 Pages 2005
Synthesis and evaluation of anti-HIV activity of isatin β-thiosemicarbazone derivatives Fulltext Access 5 Pages 2005
Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors Fulltext Access 5 Pages 2005
Synthesis and biological evaluation of novel (l)-α-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents Fulltext Access 5 Pages 2005
A minimum thickness gate valve with integrated ion optics for mass spectrometry Fulltext Access 5 Pages 2005
A Study on Mass Spectrometry of Methylated [60] Fullerenes Using the “In-beam” Electron Impact Technique Fulltext Access 5 Pages 2005
Ion Funnels for the Masses: Experiments and Simulations with a Simplified Ion Funnel Fulltext Access 5 Pages 2005
Identification of a new source of interference leached from polypropylene tubes in mass-selective analysis Fulltext Access 5 Pages 2005
Trap for MAbs: Characterization of intact monoclonal antibodies using reversed-phase HPLC on-line with ion-trap mass spectrometry Fulltext Access 5 Pages 2005
ZoomQuant: An application for the quantitation of stable isotope labeled peptides Fulltext Access 5 Pages 2005
Evidence for Unfolding and Refolding of Gas-Phase Cytochrome c Ions in a Paul Trap Fulltext Access 5 Pages 2005
Porous Anodic Alumina Membrane as a Sample Support for MALDI-TOF MS Analysis of Salt-Containing Proteins Fulltext Access 5 Pages 2005
Immobilization of Aminophenylboronic Acid on Magnetic Beads for the Direct Determination of Glycoproteins by Matrix Assisted Laser Desorption Ionization Mass Spectrometry Fulltext Access 5 Pages 2005
MALDI Mass Spectrometry Analysis of High Molecular Weight Proteins from Whole Bacterial Cells: Pretreatment of Samples with Surfactants Fulltext Access 5 Pages 2005
Characterization of an N-acylated glucagon-like peptide-1 derivative by electron capture dissociation Fulltext Access 5 Pages 2005
Inhibitors of phenylethanolamine N-methyltransferase devoid of α2-adrenoceptor affinity Fulltext Access 5 Pages 2005
Intracellular analysis of Saccharomyces cerevisiae using CLSM after ultrasonic treatments Fulltext Access 5 Pages 2005
Influence of nanoscale surface roughness on neural cell attachment on silicon Fulltext Access 5 Pages 2005
A review: Integrin αvβ3-targeted molecular imaging and therapy in angiogenesis Fulltext Access 5 Pages 2005
Simulating adsorption of n-heptane in the Pt/Al2O3 model: Influence of platinum Fulltext Access 5 Pages 2005
N-[2-(Indan-1-yl)-3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE, ECE): In vitro and In vivo activities Fulltext Access 5 Pages 2005
Structure–activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads Fulltext Access 5 Pages 2005
Hydantoin derivative formation from oxidation of 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxodG) and incorporation of 14C-labeled 8-oxodG into the DNA of human breast cancer cells Fulltext Access 5 Pages 2005
A new strategy for the synthesis of hydroxylated pyrrolizidinic alkaloids by highly stereoselective indium-mediated allylation of pyrrolidinic aldehydes Fulltext Access 5 Pages 2005
The asymmetric Michael-type alkylation of chiral β-enamino esters: critical role of a benzyl ester group in the racemization of adducts Fulltext Access 5 Pages 2005
High enantio- and diastereoselective induction of BINOL- and TADDOL-modified vinyloxy ethoxides in C-C coupling reactions with aldehydes Fulltext Access 5 Pages 2005
A convenient synthesis of the enantiomerically pure β-blocker (S)-betaxolol using hydrolytic kinetic resolution Fulltext Access 5 Pages 2005
First enantiopure calix[6]aza-cryptand: synthesis and chiral recognition properties towards neutral molecules Fulltext Access 5 Pages 2005
An efficient enzyme-catalyzed kinetic resolution: large-scale preparation of an enantiomerically pure indole-ethyl ester derivative, a key component for the synthesis of a prostaglandin D2 receptor antagonist, an anti-allergic rhinitis drug candidate Fulltext Access 5 Pages 2005
Memory of chirality trapping of low inversion barrier 1,4-benzodiazepin-2-one enolates Fulltext Access 5 Pages 2005
The bidentate complexes of (R,R)- and meso-α,α′-bis(trifluoromethyl)-9,10-anthracenedimethanol with cis-1-amino-2-indanol Fulltext Access 5 Pages 2005
Microbial oxidation/amidation of benzhydrylsulfanyl acetic acid. Synthesis of (+)-modafinil Fulltext Access 5 Pages 2005
Synthesis of sterically controlled chiral β-amino alcohols and their application to the catalytic asymmetric sulfoxidation of sulfides Fulltext Access 5 Pages 2005
Improved preparation of β-hydroxy-α-amino acids: direct formation of sulfates by sulfuryl chloride Fulltext Access 5 Pages 2005
Stereodifferentiation in the fluorescence of naproxen–arginine salts in the solid state Fulltext Access 5 Pages 2005
Thioether–phosphinite and diphosphinite ligands derived from d-xylose for the copper-catalyzed asymmetric 1,4-addition to 2-cyclohexenone Fulltext Access 5 Pages 2005
Preparation of (S)-mandelic acids by enantioselective degradation of racemates with a new isolate Pseudomonas putida ECU1009 Fulltext Access 5 Pages 2005
Application of the N-hydroxymethyl group to the stereoselective synthesis of (3S,4S)-3-aminodeoxystatine derivatives Fulltext Access 5 Pages 2005
A method to greatly improve the enantioselectivity of lipase-catalyzed hydrolysis using sodium dodecyl sulfate (SDS) as an additive Fulltext Access 5 Pages 2005
Synthesis of 3 or 3,3′-substituted BINOL ligands and their application in the asymmetric addition of diethylzinc to aromatic aldehydes Fulltext Access 5 Pages 2005
Enantiopure cycloheptenones from (R)-(−)-carvone: intermediates for perhydroazulene terpenoids Fulltext Access 5 Pages 2005
A stereoselective synthesis of (2S,4R)-δ-hydroxyleucine methyl ester: a component of cyclomarin A Fulltext Access 5 Pages 2005
Preliminary studies on the synthesis of rancinamycins from nitrosugars: first total synthesis of (3S,4S,5S,6R)-5-benzyloxy-6-hydroxy-3,4-(isopropylidendioxy)-cyclohex-1-enecarbaldehyde Fulltext Access 5 Pages 2005
A new and effective method for providing optically active monosubstituted malononitriles: selective reduction of α,β-unsaturated dinitriles catalyzed by copper hydride complexes Fulltext Access 5 Pages 2005
Asymmetric synthesis of 1,4-amino alcohol ligands with a norbornene backbone for use in the asymmetric diethylzinc addition to benzaldehyde Fulltext Access 5 Pages 2005
Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors Fulltext Access 5 Pages 2005
Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists Fulltext Access 5 Pages 2005
Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: Synthesis and structure–activity relationships Fulltext Access 5 Pages 2005
2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV Fulltext Access 5 Pages 2005
Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1 Fulltext Access 5 Pages 2005
Asymmetric synthesis of O-benzoyl cyanohydrins by reaction of aldehydes with benzoyl cyanide catalysed by BINOLAM–Ti(IV) complexes Fulltext Access 5 Pages 2005
Preparation of the four stereoisomers of 3-bromo-2-butanol or their acetates via lipase-catalysed resolutions of the racemates derived from dl- or meso-2,3-butanediol Fulltext Access 5 Pages 2005
Resolution of non-protein amino acids via Carica papaya lipase-catalyzed enantioselective transesterification Fulltext Access 5 Pages 2005
Highly stereoselective preparation of (3R,4S)-3,4-chromanediol by deracemization of (±)-3-hydroxy-4-chromanone by Trichosporon cutaneum Fulltext Access 5 Pages 2005
Influence on the enantioselectivity in allylic alkylation of the spacer between the amido group of d-glucosamine and the diphenylphosphino group Fulltext Access 5 Pages 2005
In Situ Structural Characterization of Phosphatidylcholines in Brain Tissue Using MALDI-MS/MS Fulltext Access 5 Pages 2005
Synthesis, structure, and stereochemistry of the bora derivatives of 1-[(2-hydroxy-1-naphthyl)methyl]proline Fulltext Access 5 Pages 2005
A re-investigation of Modena’s protocol for the asymmetric oxidation of prochiral sulfides Fulltext Access 5 Pages 2005
Chemoenzymatic synthesis of N-Boc protected (2S,3R)-3-hydroxy-3-methylproline Fulltext Access 5 Pages 2005
Short enantioselective synthesis of sedridines, ethylnorlobelols and coniine via reagent-based differentiation Fulltext Access 5 Pages 2005
Stereo- and regioselective construction of vicinal stereogenic quaternary carbon atoms: enantiospecific approach to cyperanes Fulltext Access 5 Pages 2005
Synthesis of (S)-(−)- and (R)-(+)-O-methylbharatamine using a diastereoselective Pomeranz–Fritsch–Bobbitt methodology Fulltext Access 5 Pages 2005
Fluorescent probes of d-(+)-gluconic acid δ-lactone based on binary hosts of chiral calix[5]arene Fulltext Access 5 Pages 2005
A simple and practical approach to enantiomerically pure (S)-3-hydroxy-γ-butyrolactone: synthesis of (R)-4-cyano-3-hydroxybutyric acid ethyl ester Fulltext Access 5 Pages 2005
Univocal syntheses of 2- and 3-hydroxymethyl-2,3-dihydro[1,4]dioxino[2,3-b]pyridine enantiomers Fulltext Access 5 Pages 2005