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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Antibacterial efficacy of Withania somnifera (ashwagandha) an indigenous medicinal plant against experimental murine salmonellosis
Fulltext Access 7 Pages 2005
Extracts and constituents of Lavandula multifida with topical anti-inflammatory activity
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Activity of taraxasteryl acetate on inflammation and heat shock protein synthesis
Fulltext Access 7 Pages 2005
The immunophilin ligand FK506 protects against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum
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Pharmacological assay of Cordia verbenacea V: oral and topical anti-inflammatory activity, analgesic effect and fetus toxicity of a crude leaf extract
Fulltext Access 7 Pages 2005
Zea mays L. extracts modify glomerular function and potassium urinary excretion in conscious rats
Fulltext Access 7 Pages 2005
Serotonin transporter mutations associated with obsessive-compulsive disorder and phosphorylation alter binding affinity for inhibitors
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Release of l-aspartate by reversal of glutamate transporters
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Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons
Fulltext Access 7 Pages 2005
The β subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors
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Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study
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Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome
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ATP hydrolysis is required for the rapid regulation of AMPA receptors during basal synaptic transmission and long-term synaptic plasticity
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Impact of Chisan® (ADAPT-232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumonia
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Oleoylethanolamide, an endogenous PPAR-α agonist, lowers body weight and hyperlipidemia in obese rats
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Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells
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Evaluation of the effect of aqueous extract of Croton urucurana Baillon (Euphorbiaceae) on the hemorrhagic activity induced by the venom of Bothrops jararaca, using new techniques to quantify hemorrhagic activity in rat skin
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Anti-oxidant activity and effect of Pinus morrisonicola Hay. on the survival of leukemia cell line U937
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Effects of water extract of Usnea longissima on antioxidant enzyme activity and mucosal damage caused by indomethacin in rats
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Accumulation of anandamide: Evidence for cellular diversity
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A second N-acylethanolamine hydrolase in mammalian tissues
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Effect of oral administration of freshly pressed juice of Echinacea purpurea on the number of various subpopulations of B- and T-lymphocytes in healthy volunteers: Results of a double-blind, placebo-controlled cross-over study
Fulltext Access 7 Pages 2005
The secretagogue effect of the poison from Centruroides limpidus limpidus on the pancreas of mice and the antagonistic action of the Bouvardia ternifolia extract
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Anti-ulcer and anti-oxidant activity of Pepticare, a herbomineral formulation
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Lycium barbarum glycoconjugates: effect on human skin and cultured dermal fibroblasts
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Antitoxin activity of plants used in Mexican traditional medicine against scorpion poisoning
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A potential role for centrosomal deregulation within IgH translocation-positive myeloma
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Nutritional modulation of parathyroid hormone secretion may influence risk for left ventricular hypertrophy
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Relativistic parameters of senescence
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Suppression of the acute-phase response as a biological mechanism for the placebo effect
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Iloprost: an adjunctive approach to chronic viral hepatitis treatment
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Scopolamine-induced convulsions in fasted mice after food intake: effects of glucose intake, antimuscarinic activity and anticonvulsant drugs
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Herbal remedies improve the strength of repairing ligament in a rat model
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Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination
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Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts
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5-Hydroxytryptamine induced excitation and inhibition in the subthalamic nucleus: Action at 5-HT2C, 5-HT4 and 5-HT1A receptors
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Chemoprotective activity of an extract of Phyllanthus amarus against cyclophosphamide induced toxicity in mice
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Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus
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Inhibition of cyclooxygenase-2 elicits a CB1-mediated decrease of excitatory transmission in rat CA1 hippocampus
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Effect of naturally occurring isothiocyanates in the inhibition of cyclophosphamide-induced urotoxicity
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Effects of lichen heteroglycans on proliferation and IL-10 secretion by rat spleen cells and IL-10 and TNF-α secretion by rat peritoneal macrophages in vitro
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The effect of adlay oil on plasma lipids, insulin and leptin in rat
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A phase I clinical study of Andrographis paniculata fixed combination Kan Jang™ versus ginseng and valerian on the semen quality of healthy male subjects
Fulltext Access 7 Pages 2005
Comparative uptakes and biodistributions of internalizing vs. noninternalizing copper-64 radioimmunoconjugates in cell and animal models of colon cancer
Fulltext Access 8 Pages 2005
Carbon-11 labeled σ2 receptor ligands for imaging breast cancer
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Imaging of HER2/neu-positive BT-474 human breast cancer xenografts in athymic mice using 111In-trastuzumab (Herceptin) Fab fragments
Fulltext Access 8 Pages 2005
Basic characterization of 64Cu-ATSM as a radiotherapy agent
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Synthesis and evaluation of inhaled [11C]butane and intravenously injected [11C]acetone as potential radiotracers for studying inhalant abuse
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In vivo evaluation of [123I]-4-iodo-N-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-benzamide: a potential sigma receptor ligand for SPECT studies
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The in vivo characteristics of genetically engineered divalent and tetravalent single-chain antibody constructs
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Potential of [11C]DASB for measuring endogenous serotonin with PET: binding studies
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Preparation of highly specific radioactivity [18F]flumazenil and its evaluation in cynomolgus monkey by positron emission tomography
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Axonal transport of rubidium and thallium in the olfactory nerve of mice
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Correlation between 99mTc-MIBI uptake and angiogenesis in MIBI-positive breast lesions
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Uptake in melanoma cells of N-(2-diethylaminoethyl)-2-iodobenzamide (BZA2), an imaging agent for melanoma staging: relation to pigmentation
Fulltext Access 8 Pages 2005
Comparison of P-glycoprotein-mediated drug-digoxin interactions in Caco-2 with human and rodent intestine: Relevance to in vivo prediction
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Cell line-dependent differences in uptake and retention of the hypoxia-selective nuclear imaging agent Cu-ATSM
Fulltext Access 8 Pages 2005
Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypes
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Synthesis, enantiomeric resolution, F-18 labeling and biodistribution of reboxetine analogs: promising radioligands for imaging the norepinephrine transporter with positron emission tomography
Fulltext Access 8 Pages 2005
Imaging apoptosis in vivo using 124I-annexin V and PET
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Synthesis, in vitro binding and biodistribution in B16 melanoma-bearing mice of new iodine-125 spermidine benzamide derivatives
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A preliminary PET evaluation of the new dopamine D2 receptor agonist [11C]MNPA in cynomolgus monkey
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Improved posthypoxic recovery in vitro on treatment with drugs used for secondary stroke prevention
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Synthesis and evaluation of [11C]FR194921 as a nonxanthine-type PET tracer for adenosine A1 receptors in the brain
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New treatments for cocaine abuse
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Pharmacotherapy of alcohol dependence: Targeting a complex disorder
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Involvement of sigma (σ) receptors in the acute actions of methamphetamine: Receptor binding and behavioral studies
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Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist
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Dyskinesias in normal squirrel monkeys induced by nomifensine and levodopa
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mGlu and NMDA receptor contributions to capsaicin-induced thermal and mechanical hypersensitivity
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Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats
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Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells
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Adenosine receptors co-operate with NMDA preconditioning to protect cerebellar granule cells against glutamate neurotoxicity
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Neuroprotective effect of zVAD against the neurotoxin 3-nitropropionic acid involves inhibition of calpain
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The oxidative neurotoxicity of clioquinol
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The mGlu5 receptor antagonists MPEP and MTEP attenuate behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons in rats
Fulltext Access 8 Pages 2005
Ambroxol, a Nav1.8-preferring Na+ channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain
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Δ9-Tetrahydrocannabinol-induced desensitization of cannabinoid-mediated inhibition of synaptic transmission between hippocampal neurons in culture
Fulltext Access 8 Pages 2005
Mefloquine inhibits cholinesterases at the mouse neuromuscular junction
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Agonists of peroxisome proliferator-activated receptor-γ attenuate the Aβ-mediated impairment of LTP in the hippocampus in vitro
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Médicaments actuels et optimisation
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À propos d'une expérience d'organisation de dispensation journalière individuelle nominative (DJIN)
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Validation des conditions de conservation des produits de santé thermosensibles : obligations et modalités pratiques dans une PUI
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Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release
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Kynurenine 3-mono-oxygenase inhibitors reduce glutamate concentration in the extracellular spaces of the basal ganglia but not in those of the cortex or hippocampus
Fulltext Access 8 Pages 2005
Opposite effects of lithium and valproic acid on trophic factor deprivation-induced glycogen synthase kinase-3 activation, c-Jun expression and neuronal cell death
Fulltext Access 8 Pages 2005
Erreurs liées au conditionnement des médicaments : quelles mesures prendre pour les réduire ?
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KW-6002 protects from MPTP induced dopaminergic toxicity in the mouse
Fulltext Access 8 Pages 2005
Zaltoprofen inhibits bradykinin-induced responses by blocking the activation of second messenger signaling cascades in rat dorsal root ganglion cells
Fulltext Access 8 Pages 2005
Pain measurements and side effect profile of the novel cannabinoid ajulemic acid
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Evidence that (−)-7-hydroxy-4′-dimethylheptyl-cannabidiol activates a non-CB1, non-CB2, non-TRPV1 target in the mouse vas deferens
Fulltext Access 8 Pages 2005
Cannabinoid CB1 antagonist SR 141716A attenuates reinstatement of heroin self-administration in heroin-abstinent rats
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The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect
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Lack of functional D2 receptors prevents the effects of the D3-preferring agonist (+)-PD 128907 on dialysate dopamine levels
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The lateral septal area is involved in the pressor pathway activated by microinjection of norepinephrine into the rat brain cingulate cortex
Fulltext Access 8 Pages 2005
The effect of a systemically active ORL-1 agonist, Ro 64-6198, on the acquisition, expression, extinction, and reinstatement of morphine conditioned place preference
Fulltext Access 8 Pages 2005
High affinity, heterogeneous displacement of [3H]EBOB binding to cerebellar GABAA receptors by neurosteroids and GABA agonists
Fulltext Access 8 Pages 2005
Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist
Fulltext Access 8 Pages 2005
The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia
Fulltext Access 8 Pages 2005
Autoradiography in opioid triple knockout mice reveals opioid and opioid receptor like binding of naloxone benzoylhydrazone
Fulltext Access 8 Pages 2005
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