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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Berberine inhibits arylamine N-acetyltransferase activity and gene expression in mouse leukemia L 1210 cells
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Transport of anti-allergic drugs across the passage cultured human nasal epithelial cell monolayer
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The rheological properties of self-emulsifying systems, water and microcrystalline cellulose
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Anti-inflammatory profile of dehydrocostic acid, a novel sesquiterpene acid with a pharmacophoric conjugated diene
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Cetirizine dihydrochloride interaction with some diclofenac complexes
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Bupivacaine salts of diflunisal and other aromatic hydroxycarboxylic acids: Aqueous solubility and release characteristics from solutions and suspensions using a rotating dialysis cell model
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Studies on the formation of O/W nano-emulsions, by low-energy emulsification methods, suitable for pharmaceutical applications
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Bioreversible quaternary N-acyloxymethyl derivatives of the poorly soluble tertiary amine Lu 28-179-Synthesis, pharmaceutical chemical characterization and bioavailability studies in dogs
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Inhibitory effects of Cnidium officinale Makino and Tabanus fulvus Meigan on the high glucose-induced proliferation of glomerular mesangial cells
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A randomized, double-blind, placebo-controlled, clinical dose-response trial of an extract of Baptisia, Echinacea and Thuja for the treatment of patients with common cold
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Efficacy of a Comfrey root extract ointment in comparison to a Diclo-fenac gel in the treatment of ankle distortions: Results of an observer-blind, randomized, multicenter study
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Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition
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Antifungal constituents of Northern prickly ash, Zanthoxylum americanum Mill.
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Adaptation and optimization of the emulsification-diffusion technique to prepare lipidic nanospheres
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Inhibition of the myotoxic activity of Bothrops jararacussu venom and its two major myotoxins, BthTX-I and BthTX-II, by the aqueous extract of Tabernaemontana catharinensis A. DC. (Apocynaceae)
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In vitro decreases of the fibrinolytic potential of cultured human fibrosarcoma cell line, HT1080, by Nigella sativa oil
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Low-dose Tadenan protects the rabbit bladder from bilateral ischemia/reperfusion-induced contractile dysfunction
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Aqueous extract of Anoectochilus formosanus attenuate hepatic fibrosis induced by carbon tetrachloride in rats
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The effect of turmeric extracts on inflammatory mediator production
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A randomized trial of Korodin® Herz-Kreislauf-Tropfen as add-on treatment in older patients with orthostatic hypotension
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Are genes of human intelligence related to the metabolism of thyroid and steroids hormones? - Endocrine changes may explain human evolution and higher intelligence
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Can arteries of skeletal muscles act as a circulatory bottleneck during heavy exercise?
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Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?
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Can a herpes simplex virus type 1 neuroinvasive score be correlated to other risk factors in Alzheimer's disease?
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Neuropharmacology of theophylline induced stuttering: the role of dopamine, adenosine and GABA
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Characterization of the 13-cis-retinoic acid/cyclodextrin inclusion complexes by phase solubility, photostability, physicochemical and computational analysis
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In vitro versus canine data for predicting input profiles of isosorbide-5-mononitrate from oral extended release products on a confidence interval basis
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Oesophageal bioadhesion of sodium alginate suspensions
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Preparation of chitosan beads by simultaneous cross-linking/insolubilisation in basic pH
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Brain penetration of synthetic adenosine A1 receptor agonists in situ: role of the rENT1 nucleoside transporter and binding to blood constituents
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Contribution of academic research to discovery and development of medicines: current status and future opportunities
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Clinical study of solid dispersions of itraconazole prepared by hot-stage extrusion
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Evaluation of a chylomicron flow blocking approach to investigate the intestinal lymphatic transport of lipophilic drugs
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Influence of flow rate on the disposition of levofloxacin and netilmicin in the isolated rat lung
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Microcalorimetric studies of the effects on the interactions of human recombinant interferon-α2a
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Bioreversible quaternary N-acyloxymethyl derivatives of the tertiary amines bupivacaine and lidocaine-synthesis, aqueous solubility and stability in buffer, human plasma and simulated intestinal fluid
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A simple method for differentiation of monoisotopic drug metabolites with hydrogen-deuterium exchange liquid chromatography/electrospray mass spectrometry
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A solid-state NMR study of molecular mobility and phase separation in co-spray-dried protein-sugar particles
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The fetus cannot exercise like an astronaut: gravity loading is necessary for the physiological development during second half of pregnancy
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Melt sonocrystallization of ibuprofen: Effect on crystal properties
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Physical stability of the amorphous state of loperamide and two fragment molecules in solid dispersions with the polymers PVP-K30 and PVP-VA64
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Polyelectrolyte complex formation and stability when mixing polyanions and polycations in salted media: A model study related to the case of body fluids
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Synthesis and antiamoebic activity of 3,7-dimethyl-pyrazolo[3,4-e][1,2,4] triazin-4-yl thiosemicarbazide derivatives
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SDS-aided immobilization and controlled release of camptothecin from agarose hydrogel
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Effect of experimental pH on the in vitro permeability in intact rabbit intestines and Caco-2 monolayer
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Can protonated β-blockers interact with biomembranes stronger than neutral isolipophilic compounds?
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Geometric mean ratio-dependent scaled bioequivalence limits with leveling-off properties
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Effect of lipophilic counter-ions on membrane diffusion of benzydamine
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The use of an in vitro dissolution and absorption system to evaluate oral absorption of two weak bases in pH-independent controlled-release formulations
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Instructions to Authors
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Genetic Variations and Haplotypes of CYP2C19 in a Japanese Population
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Application of Ultrasonic Shear Rheometer to Characterize Rheological Properties of High Protein Concentration Solutions at Microliter Volume
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Hepatobiliary Disposition of Liposomal Amphotericin B in the Isolated Perfused Rat Liver
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Simple Strategies for Reducing Sample Loads in In Vitro Metabolic Stability High-Throughput Screening Experiments: A Comparison between Traditional, Two-Time-Point and Pooled Sample Analyses
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Biopharmaceutical Considerations on Antihistamine Effects of Topically Administered Emedastine
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Nuclear magnetic resonance investigation of the interaction of water vapor with sildenafil citrate in the solid state
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Methyl esters of N‐(dicyclohexyl)acetyl‐piperidine‐4‐(benzylidene‐4‐carboxylic acids) as drugs and prodrugs: A new strategy for dual inhibition of 5α‐reductase type 1 and type 2
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Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction
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Structures from lysine-based dendrons and dendrimers: monolayers, dendriplexes, dendrisomes, nanoparticles and micellar aggregates
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Hexakis (3,6-anhydro) tetrakis (2A,B,D,E-O-butyl) cyclomalto hexaose as a promising biological cation cryptant: complexation and NMR study of interaction with membranes
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Versatility of three techniques for preparing ibuprofen-loaded methacrylic acid copolymer nanoparticles of controlled sizes
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Evaluation of statistical design/modeling for prediction of the effect of amino acids on agitation-induced aggregation of human growth hormone and human insulin
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Cation complexing 2-O-alkylated, 3,6-anhydro-α-cyclodextrins: the side-chain length governs physicochemical properties and practical applications
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Role of Organic Anion Transporting Polypeptide 2 in Pharmacokinetics of Digoxin and β-Methyldigoxin in Rats
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The Quantitative Prediction of In Vivo Enzyme-Induction Caused by Drug Exposure from In Vitro Information on Human Hepatocytes
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Evaluation of Bayesian Predictability of Vancomycin Concentration Using Population Pharmacokinetic Parameters in Pediatric Patients
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Genetic Variations and Haplotypes of UGT1A4 in a Japanese Population
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Role of Human Liver Cytochrome P450 2C9 in the Metabolism of a Novel α4β1/α4β7 Dual Antagonist, TR-14035
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Metformin is a Superior Substrate for Renal Organic Cation Transporter OCT2 rather than Hepatic OCT1
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Pharmacokinetics and Pharmacodynamics of Landiolol Hydrochloride, an Ultra Short-acting β1-Selective Blocker, in a Dose Escalation Regimen in Healthy Male Volunteers
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Cationic Analog of Deoxycholate as an Oral Delivery Carrier for Ceftriaxone
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Formation and characterization of porous indomethacin-PVP coprecipitates prepared using solvent-free supercritical fluid processing
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Quantifying Errors in Tableting Data Analysis Using the Ryshkewitch Equation Due to Inaccurate True Density
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Solubility and Prediction of the Heat of Solution of Sodium Naproxen in Aqueous Solutions
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Effect of Chloride ion on Dissolution of Different Salt Forms of Haloperidol, a Model Basic Drug
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Alternative antiglycation mechanisms: are spermine and fructosamine-3-kinase part of a carbonyl damage control pathway?
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Can the combination of localized “proliferative therapy” with “minor ozonated autohemotherapy” restore the natural healing process?
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The role and effectiveness of bone marrow in osseous regeneration
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A novel theory: biological processes mostly involve two types of mediators, namely general and specific mediators
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Does the cell-brain theory work in explaining carcinogenesis?
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The plasmodial apicoplast was retained under evolutionary selective pressure to assuage blood stage oxidative stress
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Potential utility of natural polyphenols for reversing fat-induced insulin resistance
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Noncoding DNA and the teem theory of inheritance, emotions and innate behaviour
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A possible link between multiple sclerosis and Creutzfeldt-Jakob disease based on clinical, genetic, pathological and immunological evidence involving Acinetobacter bacteria
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A quantum biological hypothesis of human secondary dentinogenesis
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Risk analysis of ectoparasites acting as vectors for chronic wasting disease
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Could visible light contribute to the development of leukaemia and other cancers in children?
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Swelling of hepatocytes injured by oxidative stress suggests pathological changes related to macromolecular crowding
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Transdermal Iontophoretic Delivery of Triptorelin in Vitro
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Assessing the efficacy of antidepressants: The transactional paradigm
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Cardiac torsion and electromagnetic fields: The cardiac bioinformation hypothesis
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Prion protein: A pattern recognition receptor for viral components and uric acid responsible for the induction of innate and adaptive immunity
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Elevated lung cancer risk shortly after smoking cessation: Is it due to a reduction of endotoxin exposure?
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The role of dorsal shear forces in the pathogenesis of adolescent idiopathic scoliosis - A hypothesis
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Munchausen's syndrome by proxy and Lyme disease: Medical misogyny or diagnostic mystery?
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Contribution of ROCK in Contraction of Trabecular Meshwork: Proposed Mechanism for Regulating Aqueous Outflow in Monkey and Human Eyes
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Oral heparin delivery: Design and in vivo evaluation of a stomach-targeted mucoadhesive delivery system
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Preparation of polymeric nanocapsules containing octyl methoxycinnamate by the emulsification-diffusion technique: Penetration across the stratum corneum
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Erosion of microbicide formulation coating layers: Effects of contact and shearing with vaginal fluid or semen
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Influence of macromolecular crowding upon the stability and state of association of proteins: Predictions and observations
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