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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Macrocyclization studies and total synthesis of cyclomarin C, an anti-inflammatory marine cyclopeptide
Fulltext Access 8 Pages 2005
Self-assembly of a novel series of hetero-duplexes driven by donor-acceptor interaction
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Graphical contents list
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An unusual stereochemical outcome of radical cyclization: synthesis of (+)-biotin
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A general strategy for the synthesis of azapeptidomimetic lactams
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Resolution of non-protein amino acids via the microbial protease-catalyzed enantioselective hydrolysis of their N-unprotected esters
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New pyrrolopyridazine derivatives as blue organic luminophors
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A convergent and stereoselective synthesis of a seco-precursor of macrolactin A
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Synthesis and reactivity profiles of phosphinated poly(alkyl aryl ether) dendrimers
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Isoprene-catalyzed lithiation of imidazole: synthesis of 2-(hydroxyalkyl)- and 2-(aminoalkyl)imidazoles
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Graphical contents list
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Base catalyzed intramolecular transamidation of 2-aminoquinazoline derivatives on solid phase
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Substituted coumarin amidines: useful building blocks for the preparation of [1]benzopyrano[4,3-b]pyridin-5-one and [1]benzopyrano[4,3-d]pyrimidin-5-one derivatives
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The effects of cationic and zwitterionic micelles on the keto-enol interconversion of 2-phenylacetylfuran and 2-phenylacetylthiophene
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Graphical contents list
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Synthesis of thiazo- or thiadiazo- naphthalene carboxamides via mercuric intermediates and their antitumor and DNA photocleavage activities
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Michael addition of phosphorus derivatives on tetraethyl ethylidenediphosphonate
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Mild and efficient copper-catalyzed N-arylation of alkylamines and N-H heterocycles using an oxime-phosphine oxide ligand
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Multiple hydrogen-bond-induced supramolecular nanostructure from a pincer-like molecule and a [60]fullerene derivative
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4-Substituted prolines as organocatalysts for aldol reactions
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New domino reaction. One pot synthesis of 4,7-dihydroxythioaurone derivatives from benzaldehydes and 4-acetyl-2-oxo-benz[1,3]oxathiole
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Application of recoverable nanosized palladium(0) catalyst in Sonogashira reaction
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Synthesis and characterization of novel fluorescent N-glycoconjugates
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Michael additions catalyzed by phosphines. An overlooked synthetic method
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Metallation of pyridin-2-yldiazines. Use of pyridine ring as ortho-directing group. Diazines. Part 45
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Organocatalysts of tertiary-phosphines and amines catalyzed reactions of α-keto esters with cyclopent-2-enone
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Graphical contents list
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Graphical contents list
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Graphical contents list
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High temperature bromination. Part 18: Bromination of benzonorbornadiene derivatives: Polybrominated benzonorbornenes and benzonorbornadienes
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The role of charge transfer interactions in the inclusion complexation of anionic guests with α-cyclodextrin
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Graphical contents list
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Polyhydroxylated pyrrolidines, III. Synthesis of new protected 2,5-dideoxy-2,5-iminohexitols from d-fructose
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Modular chiral selenium-containing oxazolines: synthesis and application in the palladium-catalyzed asymmetric allylic alkylation
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RETRACTED: Biomimetic approach to Galbulimina type I alkaloids
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Vinylsulfones versus alkylsulfones in the addition to chiral imines. Synthesis of N-(tert-butoxycarbonyl)-l-homophenylalanine
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Synthesis of tricyanovinyl-substituted thienylpyrroles and characterization of the solvatochromic, electrochemical and non-linear optical properties
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Enantiopure arenesulfenic acids as intermediates in stereoselective synthesis
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A convenient and efficient ring-opening reaction of aziridines with acetylenes and synthesis of dihydropyrroles
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Pluri-dimensional hydrogen-bonded networks of novel thiophene-introduced oligo(imidazole)s and physical properties of their charge-transfer complexes with TCNQ
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Oxidations of erogorgiaene in pseudopterosin biosynthesis
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Wurster's crownophanes: an alternate topology for para-phenylenediamine-based macrocycles
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Synthetic protocols and building blocks for molecular electronics
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Five novel flavonoids from Wasabia japonica
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Pallado-catalysed P-arylations and P-vinylation of 2-hydrogeno-2-oxo-1,4,2-oxazaphosphinanes
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Highly enantioselective synthesis of multifunctionalized allylic building blocks via oxazaborolidine-catalyzed borane reduction
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An efficient synthesis of 5-aminolaevulinic acid (ALA)-containing peptides for use in photodynamic therapy
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A general synthesis of five, six and seven-membered silasultones via dehydrative cyclisation
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Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge
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Investigation into the regioselective C-deuteriation of α-keto esters
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Preparation of 15-membered unsaturated N-H containing azamacrocycles and their differential coordination with Pd(0) and Pd(II)
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Synthesis of functionalized polyhedral oligomeric silsesquioxane (POSS) macromers by microwave assisted 1,3-dipolar cycloaddition
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Towards new camptothecins. Part 2: Synthesis of the ABCD ring scaffold substituted by a carboxyl group in the 5-position
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Macrocyclic receptors containing sucrose skeleton
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Lewis acid-catalyzed asymmetric radical additions of trialkylboranes to (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl-2H-azirine-3-carboxylate
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Xyloccensins Q-V, six new 8,9,30-phragmalin ortho ester antifeedants from the Chinese mangrove Xylocarpus granatum
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Computational studies of benzyl-substituted halonium ions
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Graphical contents list
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Enantioselective addition of methyllithium to aromatic imines catalyzed by C2 symmetric tertiary diamines
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Metalation of sulfoxides in the benzodiazine series. Diazines. Part 44
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Search for strategies by computer: the CONAN approach. Application to steroid and taxane frameworks
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Manganese(III) acetate based oxidative cyclizations of 3-oxopropanenitriles with conjugated alkenes and synthesis of 4,5-dihydrofuran-3-carbonitriles containing heterocycles
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Facile preparation of cyclopropanes from 2-iodoethyl-substituted olefins and 1,3-dihalopropanes with zinc powder
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On the enzymatic hydrolysis of methyl 2-fluoro-2-arylpropionates by lipases
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Substituent effects on the spectroscopic properties of solvatochromic 2-phenylimidazo[1,2-a]pyrazin-3(7H)-ones: an effective control for the colorimetric sensor properties
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Co-catalyzed autoxidation of alkene in the presence of silane. The effect of the structure of silanes on the efficiency of the reaction and on the product distribution
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First selective lithiation of pyridylpiperazines: straightforward access to potent pharmacophores
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Diastereo- and regioselectivity in Diels-Alder reaction of [1,4,2]diazaphospholo[4,5-a]pyridines
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An effective new synthesis of 2-aminopyrrole-4-carboxylates
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A new route into hexahydro-cyclopenta[b]pyrrole-cis-3a,6-diols. Synthesis of constrained bicyclic analogues of pyrrolidine azasugars
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Synthesis and reactivity of 2-(porphyrin-2-yl)-1,3-dicarbonyl compounds
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Maleimide cycloadditions by sulfinyldienes: is the sulfur configuration the only controller of the diastereofacial selectivity?
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Ionic liquids for tetraarylporphyrin preparation
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Asymmetric biocatalytic hydrocyanation of pyrrole carboxaldehydes
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Synthesis and application of polytetrahydrofuran-grafted polystyrene (PS-PTHF) resin supports for organic synthesis
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Synthesis, structure, and biological aspects of cyclopeptides related to marine phakellistatins 7-9
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Structure based design of simplified analogues of insect kinins
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Electrophilic substitution reactions of trisheteroarylmethanes: an efficient strategy to develop novel synthons for organic synthesis
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Soluble and insoluble polymeric 1,3-dithiane reagents for the synthesis of aldehydes from alkyl halides
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Graphical contents list
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A stereocontrolled route to protected isocyanates from alcohols
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Carbon dendron nano-chains with π-extended conjugation based on end-capped N,N-dimethylamino in linear 1,4-phenylethynyl or in 1,5-naphthylethynyl subunits: fluorescence analysis
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Graphical contents list
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Direct and indirect reductive amination of aldehydes and ketones with solid acid-activated sodium borohydride under solvent-free conditions
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Graphical contents list
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Desilylation procedure via a naphthalene-catalysed lithiation reaction
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Diels-Alder reactivity of 4-aryl-1-phthalimido-2-siloxy-1,3-butadienes
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Intramolecular 1,3-dipolar cycloaddition of unsaturated nitrones derived from methyl α-d-glucopyranoside
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Copper (I) 1,3-R2-3,4,5,6-tetrahydropyrimidin-2-ylidenes (R=mesityl, 2-propyl): synthesis, X-ray structures, immobilization and catalytic activity
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Wittig reactions of moderate ylides with heteroaryl substituents at the phosphorus atom
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[1,2] Boc migration during pyroglutamate alkylations
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Investigation of the scope of a [3+2] cycloaddition approach to isoxazole boronic esters
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Graphical contents list
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Reactions of (Z)-3-aryl-3-chloropropenals with nucleophiles: stereoselective formation of (E)-vinylogous esters, (E)-vinylogous amides, and vinamidinium salts
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Stereoselective synthesis of microcarpalide
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Lewis acid induced [4+3] cycloadditions of 2-silyloxyacroleins. Insights on the mechanism from a DFT analysis
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7-Deaza-2,8-diazaadenine containing oligonucleotides: synthesis, ring opening and base pairing of 7-halogenated nucleosides
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Studies on the synthesis of DNA-damaging part of leinamycin: regioselectivity in Ti(OiPr)4 mediated opening of hydroxy epoxides with carboxylic acids
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Synthesis and properties of 4,9-methanoundecafulvenes and their transformation to 3-substituted 7,12-methanocycloundeca[4,5]furo[2,3-d]pyrimidine-2,4(1H,3H)-diones: photo-induced autorecycling oxidizing reaction toward amines
Fulltext Access 8 Pages 2005
Synthesis of strapped zinc chlorophyll derivatives and their complexation with a single axial ligand
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