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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Intramolecular 1,3-dipolar cycloaddition of cyclo-1,3-diene-tethered nitrile oxides
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Incorporation of an indole-containing diarylbutylamine pharmacophore into furo[2,3-a]carbazole ring systems
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Optimised synthesis and photochemistry of antenna-sensitised 1-acyl-7-nitroindolines
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Efficient synthesis of various acycloalkenyl derivatives of pyrimidine using cross-metathesis and Pd(0) methodologies
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Chelation controlled regiospecific O-substitution of myo-inositol orthoesters: convenient access to orthogonally protected myo-inositol derivatives
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Cyclodextrin assisted enantiomeric recognition of benzo[de]isoquinoline-1,3-dione derived amino acids
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Synthetic approach to pentacyclic quassinoids from communic acids, via ambracetal derivatives
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Triaryl phosphine-functionalized N-heterocyclic carbene ligands for Heck reaction
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Study on halolactamization-γ-hydroxylation or haloiminolactonization of 2,3-alkadienamides
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Stereochemical substituent effects: investigation of the cyano, amide and carboxylate group
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Palladium-mediated approach to dibenzo[b,e][1,4]diazepines and benzopyrido-analogues. An efficient synthesis of tarpane
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Conversion of 1,3-oxathiolanes to 1,4-oxathianes using a silylated diazoester
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Stereoselective synthesis of morphine fragments trans- and cis-octahydro-1H-benzo[4,5]furo[3,2-e]isoquinolines
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Synthesis and redox-active base-pairing properties of DNA incorporating mercapto C-nucleosides
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Studies on the chemistry of 2-(2-oxo-3-phenylpropyl)-benzaldehydes: novel total synthesis of 3-phenylnaphthalen-2-ols and 2-hydroxy-3-phenyl-1,4-naphthoquinones
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Cheiloclines A-I. First examples of octacyclic sesquiterpene-triterpene hetero-Diels-Alder adducts
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Development of an end-game strategy towards apoptolidin: a sequential Suzuki coupling approach
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Cryoelectrochemistry: electrochemical reduction of 2(RS)-methyl 1-(tert-butoxycarbonyl)-2-iodomethyl-2,5-dihydropyrrole-2-carboxylate
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Diastereoselective synthesis of α,β-unsaturated systems
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Tributylphosphine as a superior catalyst for the α-C-addition of 1,3-dicarbonyl compounds to electron-deficient alkynes
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Silver (I)-promoted asymmetric halohydrin reaction of chiral N-enoyl-2-oxazolidinones: scope and limitations
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Gas-phase acidity of sulfonamides: implications for reactivity and prodrug design
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Synthetic applications of aryl radical building blocks for cyclisation onto azoles
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Three dimeric anthracene derivatives from the fruits of Bulbine abyssinica
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Reaction of 3-phenylisoxazole with alkyllithiums
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Synthesis of a constrained ligand comprising carboxylate and amine donor groups via direct 1,8-functionalization of positionally protected fluorene
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Camptothecin in sterically stabilized phospholipid micelles: A novel nanomedicine
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What is nanomedicine?
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The function of the amino terminal domain in NMDA receptor modulation
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Construction of a 3D model of nattokinase, a novel fibrinolytic enzyme from Bacillus natto
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Intersurf: dynamic interface between proteins
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Modeling aided design of potent glycogen phosphorylase inhibitors
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Combining structure-based drug design and pharmacophores
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Assessment of a mechanism for reactive inhibition of carboxypeptidase A with QM/MM methods
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Accurate prediction of scorpion toxin functional properties from primary structures
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An ab initio molecular orbital study of the reduction of carbonyls by alkylaluminum complexes
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Theoretical study of aluminum arsenide clusters: Equilibrium geometries and electronic structures of AlnAsn (n = 1-4)
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Synthesis of bicyclic carbamates as precursors of Sedum alkaloid derivatives
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Synthesis and photoresponsive study of azobenzene centered polyamidoamine dendrimers
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The synthesis of baclofen and GABOB via Rh(II) catalyzed intramolecular C-H insertion of α-diazoacetamides
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One-pot synthesis of 1-aryl-3-methyl-1,3-dienes using methallyl(trimethyl)silane and aldehydes and their low temperature (Z)→(E) isomerization induced by sulfur dioxide
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Novel taxane diterpenes from Taxus sumatrana with the first C-21 taxane ester
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Comparative study of azobenzene and stilbene bridged crown ether p-tert-butylcalix[4]arene
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An improved synthesis of piperazino-piperidine based CCR5 antagonists with flexible variation on pharmacophore sites
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Bioactive steroidal glycosides from the marine sponge Erylus lendenfeldi
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Multiblock copolymer synthesis via controlled radical polymerization in aqueous dispersions. Part 1: Synthesis of S-tert-alkyl-N,N-alkoxycarbonylalkyldithiocarbamates
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Total synthesis of two 12-nordrimanes and the pharmacological active sesquiterpene hydroquinone yahazunol
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Synthesis of novel 2,5-dihydro-1,5,2-diazaphosphinines from primary enamine phosphonates and from alkyl phosphonates
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Synthesis and biological evaluation of (±)-cryptotanshinone and its simplified analogues as potent CDC25 inhibitors
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Synthesis of α-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes
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Pyridine mediated supramolecular assemblies of 3,5-dinitro substituted benzoic acid, benzamide and benzonitrile
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An efficient method for the synthesis of methyl 11α-amino-3α,7α-diacetoxy-12-oxo-5β-cholan-24-oate
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Room temperature ionic liquid promoted improved and rapid synthesis of 2,4,5-triaryl imidazoles from aryl aldehydes and 1,2-diketones or α-hydroxyketone
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A simple catalyst system for the palladium-catalyzed coupling of aryl halides with terminal alkynes
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Use of tetrahydropyrimidinium salts for highly efficient palladium-catalyzed cross-coupling reactions of aryl bromides and chlorides
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Palladium-benzimidazolium salt catalyst systems for Suzuki coupling: development of a practical and highly active palladium catalyst system for coupling of aromatic halides with arylboronic acids
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Pd2dba3/P(i-BuNCH2CH2)3N: a highly efficient catalyst for the one-pot synthesis of trans-4-N,N-diarylaminostilbenes and N,N-diarylaminostyrenes
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Ferrocenyl-palladium complexes in cross-coupling reactions: a comparative study
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Use of a bulky phosphine of weak σ-donicity with palladium as a versatile and highly-active catalytic system: allylation and arylation coupling reactions at 10−1-10−4 mol% catalyst loadings of ferrocenyl bis(difurylphosphine)/Pd
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Chemoselective Heck arylation of acrolein diethyl acetal catalyzed by an oxime-derived palladacycle
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Exhaustive degradation of the ring D of 3,20-epoxy ent-kaurane-type diterpene maoecrystal A
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Synthesis and rearrangement of cycloalkyl[1,2-e]oxazolo[3,2-a]pyrimidin-8/9-ones: an access to cycloalkyl[1,2-d]oxazolo[3,2-a]pyrimidin-5-ones
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A new strategy for the synthesis of highly functionalised fluorinated compounds by reaction of lithium dianions of carboxylic acids with perfluoroketene dithioacetals
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Bu3SnH-mediated 5-exo selective radical cyclization of N-vinyl-α,β-unsaturated amides leading to γ-lactams
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meso-Indanyl calix[4]pyrrole receptors
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Efficient and fast Heck vinylation of 2-bromo-6-methyl pyridines with methylacrylate. Application to the synthesis of 6-methyl cyclopenta[b]pyridinone
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Caldaphnidines A-F, six new Daphniphyllum alkaloids from Daphniphyllum calycinum
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Photophysical and electrochemical properties of π-extended molecular 2,1,3-benzothiadiazoles
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Bis- and tris-bicyclophosphites of d-glucofuranoside. Unexpected catalysis of P(III/V)-oxidation by triethylamine
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Tetrathiafulvalene-hydroxyamides and -oxazolines: hydrogen bonding, chirality, and a radical cation salt
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Computer-assisted design of asymmetric 1,3-dipolar cycloadditions between dimethylvinylborane and chiral nitrones
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Silicon guided rearrangement of epoxydecalines to spirocyclic compounds. Synthesis of gleenol and axenol from carvone
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Graphical contents list
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Synthesis, characterization and some properties of amide-linked porphyrin-ruthenium(II) tris(bipyridine) complexes
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New chiral porphyrin-brucine gelator characterized by methods of circular dichroism
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Graphical contents list
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A stereoselective synthesis of spiro-dioxolanes via the multicomponent reaction of dicarbomethoxycarbene, aldehydes and 1,2- or 1,4-diones
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Asymmetric synthesis of aryloxypropanolamines via OsO4-catalyzed asymmetric dihydroxylation
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Hairpin conformation of amphidinols possibly accounting for potent membrane permeabilizing activities
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Stereoselective syntheses of tri- and tetrapeptide analogues by dynamic resolution of α-halo amides in nucleophilic substitution
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Base-assisted intramolecular 6-acetoxypyranone-acetylene [5+2] cycloaddition. Synthesis and reactivity of novel oxa-tricyclo[5.3.1.01,5]undecenones
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Synthesis of 2-methyl- and 2-methylenecyclobutane amino acids
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Studies on t-BuOK-catalyzed Michael addition of 1,2-allenic ketones with 2-substituted diethyl malonates: highly selective synthesis of β,γ-unsaturated enones
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Synthesis of (±)-5′-methoxyhydnocarpin-D, an inhibitor of the Staphylococcus aureus multidrug resistance pump
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The synthesis and applications of asymmetric phase-transfer catalysts derived from isomannide and isosorbide
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Octaalkylphthalocyaninato ruthenium(II) complexes with mixed axial ligands and supramolecular porphyrin:phthalocyanine structures derived from them
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Slipping of a histidine improved the peroxidase activity of a de novo designed polypeptide packing an iron porphyrin
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Cyclocondensations of (+)-camphor derived enaminones with hydrazine derivatives
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Efficient synthesis of fluorothiosparfosic acid analogues with potential antitumoral activity
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Synthesis and biological evaluation of 3-amino-propan-1-ol based poly(ether imine) dendrimers
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Photochemical synthesis of benzoxazolo[3,2-b]isoquinolin-11-one and isoquinolino[3,2-b][1,3]benzoxazin-11-one under basic conditions
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Thienylpyrrole azo dyes: synthesis, solvatochromic and electrochemical properties
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Synthesis of 4-substituted 3-(indol-3-yl)maleimides and azepines with annelated indole and maleimide nuclei
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New and efficient synthesis of bi- and trisubstituted indazoles
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Crowned dendron: ion-responsive flexibility of macromolecules induced by integrated crown ether moieties
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Synthesis, NMR and X-ray characterisation of 6-substituted 4-amino-5-aryldiazenyl-1-arylpyridazinium salts
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Effects of electron-withdrawing substituents on DPPH radical scavenging reactions of protocatechuic acid and its analogues in alcoholic solvents
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Graphical contents list
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LIC-KOR promoted formation of conjugated dienes as useful building blocks for palladium-catalyzed syntheses
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Graphical contents list
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