Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding Fulltext Access 7 Pages 2005
Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers Fulltext Access 7 Pages 2005
Novel β-(imidazol-4-yl)-β-amino acids: solid-phase synthesis and study of their inhibitory activity against geranylgeranyl protein transferase type I Fulltext Access 7 Pages 2005
Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs Fulltext Access 7 Pages 2005
QSAR for anti-RNA-virus activity, synthesis, and assay of anti-RSV carbonucleosides given a unified representation of spectral moments, quadratic, and topologic indices Fulltext Access 7 Pages 2005
Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators Fulltext Access 7 Pages 2005
Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain Fulltext Access 7 Pages 2005
QSAR studies on 1,2-dithiole-3-thiones: modeling of lipophilicity, quinone reductase specific activity, and production of growth hormone Fulltext Access 7 Pages 2005
Identification of a UDP-Gal: GlcNAc-R galactosyltransferase activity in Escherichia coli VW187 Fulltext Access 7 Pages 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs? Fulltext Access 7 Pages 2005
Studies on synthesis and evaluation of quantitative structure-activity relationship of 5-[(3â²-chloro-4â²,4â²-disubstituted-2-oxoazetidinyl)(N-nitro)amino]-6-hydroxy-3-alkyl/aryl[1,3]azaphospholo[1,5-a]pyridin-1-yl-phosphorus dichlorides Fulltext Access 7 Pages 2005
QSAR study on pKa vis-Ã -vis physiological activity of sulfonamides: a dominating role of surface tension (inverse steric parameter) Fulltext Access 7 Pages 2005
Preparation and characterization of solid lipid nanoparticles (SLN) made of cacao butter and curdlan Fulltext Access 7 Pages 2005
Fast-dissolving mucoadhesive microparticulate delivery system containing piroxicam Fulltext Access 7 Pages 2005
Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug Fulltext Access 7 Pages 2005
Effects of miltefosine on membrane permeability and accumulation of [99mTc]-hexakis-2-methoxyisobutyl isonitrile, 2-[18F]fluoro-2-deoxy-d-glucose, daunorubucin and rhodamine123 in multidrug-resistant and sensitive cells Fulltext Access 7 Pages 2005
Preparation and evaluation of release characteristics of 3TabGum, a novel chewing device Fulltext Access 7 Pages 2005
Characterization of the rotating dialysis cell as an in vitro model potentially useful for simulation of the pharmacokinetic fate of intra-articularly administered drugs Fulltext Access 7 Pages 2005
Targeting liposomes with protein drugs to the blood-brain barrier in vitro Fulltext Access 7 Pages 2005
AZD3582 increases heme oxygenase-1 expression and antioxidant activity in vascular endothelial and gastric mucosal cells Fulltext Access 7 Pages 2005
Effect of staurosporine on N-glycosylation and cell adhesion to fibronectin of SW480 human colorectal adenocarcinoma cells Fulltext Access 7 Pages 2005
AMP-activated protein kinase and malonyl-CoA: Targets for treating insulin resistance? Fulltext Access 7 Pages 2005
Dipeptidyl peptidase IV inhibitors for type 2 diabetes and metabolic syndrome Fulltext Access 7 Pages 2005
Challenges and opportunities associated with targeting estrogen receptors in treating hypertension and cardiovascular disease Fulltext Access 7 Pages 2005
Peroxisome Proliferator-Activated Receptor β/δ: A novel target for the reduction of atherosclerosis Fulltext Access 7 Pages 2005
Targeting the vascular RhoA-Rho-kinase signaling pathway in hypertension Fulltext Access 7 Pages 2005
Genome scale cytometry: High content analysis for high throughput RNAi phenotype profiling Fulltext Access 7 Pages 2005
Nonviral gene delivery systems: From simple transfection agents to artificial viruses Fulltext Access 7 Pages 2005
Salt formation in solid dispersions consisting of polyacrylic acid as a carrier and three basic model compounds resulting in very high glass transition temperatures and constant dissolution properties upon storage Fulltext Access 7 Pages 2005
New poly(lactic-co-glycolic acid) derivatives: Modular polymers with tailored properties Fulltext Access 7 Pages 2005
Protein pathway analysis in Clinical Proteomics using protein microarrays Fulltext Access 7 Pages 2005
Integrating disease knowledge and technology to deliver protein targets and biomarkers into drug discovery projects Fulltext Access 7 Pages 2005
5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization Fulltext Access 7 Pages 2005
QSAR study on the antibacterial activity of some sulfa drugs: building blockers of Mannich bases Fulltext Access 7 Pages 2005
Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones Fulltext Access 7 Pages 2005
Unified Markov thermodynamics based on stochastic forms to classify drugs considering molecular structure, partition system, and biological species: Fulltext Access 7 Pages 2005
QSAR of adenosine A3 receptor antagonist 1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives using chemometric tools Fulltext Access 7 Pages 2005
Pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. Synthesis and SAR of 2-substituted 4-methyl-8-(morpholine-4-sulfonyl)-pyrrolo[3,4-c]quinoline-1,3-diones Fulltext Access 7 Pages 2005
Iminosugars as glycosyltransferase inhibitors: synthesis of polyhydroxypyrrolidines and their evaluation on chitin synthase activity Fulltext Access 7 Pages 2005
QSAR analysis of thiazole benzenesulfonamide substituted 3-pyridylethanolamines as β3-adrenergic receptor agonist Fulltext Access 7 Pages 2005
Hologram quantitative structure–activity relationships for a series of farnesoid X receptor activators Fulltext Access 7 Pages 2005
Carbonic anhydrase inhibitors: Novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX Fulltext Access 7 Pages 2005
Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines Fulltext Access 7 Pages 2005
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure–activity relationships of the 7- and 5-, 6-, 8-positions Fulltext Access 7 Pages 2005
Synthesis and bladder smooth muscle relaxing properties of substituted 3-amino-4-aryl-(and aralkyl-)cyclobut-3-ene-1,2-diones Fulltext Access 7 Pages 2005
Synthesis and structure–activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1) Fulltext Access 7 Pages 2005
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors Fulltext Access 7 Pages 2005
Structural characterization and antimicrobial activity of 1,3-bis(2-benzimidazyl)-2-thiapropane ligand and its Pd(II) and Zn(II) halide complexes Fulltext Access 7 Pages 2005
Oral delivery of G protein-coupled receptor modulators: An explanation for the observed class difference Fulltext Access 7 Pages 2005
The characterization of a novel rigid nicotine analog with α7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion Fulltext Access 7 Pages 2005
Carbonic anhydrase inhibitors: Design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma Fulltext Access 7 Pages 2005
Analysis of structure–activity relationships for the ‘A-region’ of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists Fulltext Access 7 Pages 2005
Molecular recognition of 15-deoxy-Δ12,14-prostaglandin J2 by nuclear factor-kappa B and other cellular proteins Fulltext Access 7 Pages 2005
Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid Fulltext Access 7 Pages 2005
Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs Fulltext Access 7 Pages 2005
Synthesis and antifungal activity of 2/3-arylthio- and 2,3-bis(arylthio)-5-hydroxy-/5-methoxy-1,4-naphthoquinones Fulltext Access 7 Pages 2005
Synthesis and biological evaluation of new N-substituted-Nâ²-(3,5-di/1,3,5-trimethylpyrazole-4-yl)thiourea/urea derivatives Fulltext Access 7 Pages 2005
Effects of RM-β-CD on sublingual bioavailability of Î9-tetrahydrocannabinol in rabbits Fulltext Access 7 Pages 2005
Development of a single unit extended release formulation for ZK 811 752, a weakly basic drug Fulltext Access 7 Pages 2005
Intranasal delivery of recombinant human growth hormone (somatropin) in sheep using chitosan-based powder formulations Fulltext Access 7 Pages 2005
Kinetic values for mechanism-based enzyme inhibition: Assessing the bias introduced by the conventional experimental protocol Fulltext Access 7 Pages 2005
Disorder and dissolution enhancement: Deposition of ibuprofen on to insoluble polymers Fulltext Access 7 Pages 2005
Drug permeability in 16HBE14o- airway cell layers correlates with absorption from the isolated perfused rat lung Fulltext Access 7 Pages 2005
Synthesis, in vitro cytotoxic and antiviral activity of cis-[Pt(R(-) and S(+)-2-α-hydroxybenzylbenzimidazole)2Cl2] complexes Fulltext Access 7 Pages 2005
NO-donors, part 9 [1]: diazeniumdiolates inhibit human platelet aggregation and induce a transient vasodilatation of porcine pulmonary arteries in accordance with the NO-releasing rates Fulltext Access 7 Pages 2005
HIV protease inhibitors: synthesis and activity of N-aryl-Nâ²-hydroxyalkyl hydrazide pseudopeptides Fulltext Access 7 Pages 2005
Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors Fulltext Access 7 Pages 2005
Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl)acetamido]thio-4H-1,2,4-triazole derivatives Fulltext Access 7 Pages 2005
Synthesis, physicochemical and in vitro pharmacological investigation of new platinum (II) complexes with some cycloalkanespiro-5â²-hydantoins Fulltext Access 7 Pages 2005
Synthesis and study of antibacterial and antifungal activities of novel 8-methyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones Fulltext Access 7 Pages 2005
The synthesis and antimicrobial activity of some new methyl N-arylthiocarbamates, dimethyl N-aryldithiocarbonimidates and 2-arylamino-2-imidazolines Fulltext Access 7 Pages 2005
Epoxide-containing side chains enhance antiproliferative activity of paullones Fulltext Access 7 Pages 2005
An unexpected amide bond cleavage: poly (ethylene glycol) transport forms of vancomycin. 2 Fulltext Access 7 Pages 2005
New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells Fulltext Access 7 Pages 2005
Synthesis and anticancer evaluation of certain 4-anilinofuro[2,3-b]quinoline and 4-anilinofuro[3,2-c]quinoline derivatives Fulltext Access 7 Pages 2005
Synthesis and antimalarial activity of E-2-quinolinylbenzocycloalcanones Fulltext Access 7 Pages 2005
Synthesis and antimicrobial study of novel heterocyclic compounds from hydroxybenzophenones Fulltext Access 7 Pages 2005
Synthesis and structure-activity relationships of mono- and dialkyl-substituted oxaliplatin derivatives Fulltext Access 7 Pages 2005