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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Predictive in silico modeling for hERG channel blockers
Fulltext Access 7 Pages 2005
The BCL-2 network: Mechanistic insights and therapeutic potential
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Text-mining approaches in molecular biology and biomedicine
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Finding the target after screening the phenotype
Fulltext Access 7 Pages 2005
Gastrointestinal patch systems for oral drug delivery
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Data management solutions for protein therapeutic research and development
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How many genomics targets can a portfolio afford?
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Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer
Fulltext Access 7 Pages 2005
Interdisciplinary research and education at the biology-engineering-computer science interface: a perspective
Fulltext Access 7 Pages 2005
The impact of Life Science Identifier on informatics data
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Exploring the sounds of silence: RNAi-mediated gene silencing for target identification and validation
Fulltext Access 7 Pages 2005
Quantitative risk modelling for new pharmaceutical compounds
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Transforming the work of early-stage drug discovery through bioprocess informatics
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Array-based approaches to cancer genome analysis
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A computational view of microRNAs and their targets
Fulltext Access 7 Pages 2005
Chemical modification of gene silencing oligonucleotides for drug discovery and development
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Enantioselective chromatography in drug discovery
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A new wrinkle on pain relief: re-engineering clostridial neurotoxins for analgesics
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Predicting aqueous solubility from structure
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Transferrin: structure, function and potential therapeutic actions
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The continuing evolution of shotgun proteomics
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Bridging cheminformatic metabolite prediction and tandem mass spectrometry
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Web services in the life sciences
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Artificial intelligence and robotics in high throughput post-genomics
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Ontologies and semantic data integration
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Molecular regulation of lipotoxicity in the heart
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High throughput, nanoliter quantitative PCR
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Cerebral malaria: Which parasite? Which model?
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Mouse models of Down syndrome
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Experimental models of Huntington's disease
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Models of acetylation and the regulation of longevity: From yeast to humans
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Modelling the mitochondrial role in ageing
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Models of astrocytoma
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Models of epithelial-mesenchymal transition
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Models for pancreatic cancer: Giant steps forward, miles to go
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Models of prostate cancer
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Animal models for the study of myocardial protection against ischemia
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Models of type 2 diabetes
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Methods to reveal domain networks
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Hormone therapy and platelet function
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Cardiomyocyte apoptosis in the ischemic and failing heart
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Mechanisms in homocysteine-induced vascular disease
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Molecular mechanisms of diabetic vasculopathy
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Synovial fibroblasts in joint destruction of rheumatoid arthritis
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The B cells are back!
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Compensatory response to reducing body weight
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Biology and therapeutic potential of GLP-1 in the treatment of diabetes
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Mechanisms of psoriasis
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von Hippel-Lindau-associated malignancies: Mechanisms and therapeutic opportunities
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Cancer rejection by the immune system: Forcing the check-points of tumor immune escape
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Solid-phase synthesis of imidazoquinazolinone derivatives with three-point diversity
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The trimethylsilyl xylyl (TIX) ether: a useful protecting group for alcohols
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Molecular recognition of l-leucyl-l-alanine: enantioselective inclusion of alkyl methyl sulfoxides
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A novel and efficient catalytic epoxidation of olefins and monoterpenes with microencapsulated Lewis base adducts of methyltrioxorhenium
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Synthesis of southern (C1′-C11′) fragment of pamamycin-635A
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DDQ induced oxidative cyclisations of 1,2-dihydronaptho[2,1-b]furans
Fulltext Access 7 Pages 2005
Total synthesis of TT-1 (rasfonin), an α-pyrone-containing natural product from a fungus Trichurus terrophilus
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Convenient syntheses of 1,1,1,3,3,3-hexafluoro-2-organyl-propan-2-ols and the corresponding trimethylsilyl ethers
Fulltext Access 7 Pages 2005
Distinction between stepwise and concerted mechanisms in reductive cleavage reactions-use of voltammetric current function in the analysis of non-linear kinetic laws
Fulltext Access 7 Pages 2005
The regioselective synthesis of monomethoxynaphthylene diacetates
Fulltext Access 7 Pages 2005
A polystyrene-supported triflating reagent for the synthesis of aryl triflates
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A concise benzotriazolyl-mediated synthesis of 9-methoxycepharanone A
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Evaluation of C-trialkylsilyl enol and thioenol ethers as intermediates in the synthesis of acylsilanes
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Ionic liquids as a convenient recyclable medium for the generation of transient carbonyl ylides: syntheses of oxa and dioxa-bridged polycyclic systems
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An easy ABD→ABCD strategy to indolo[2,3-a]quinolizin-4-one. Synthesis of deplancheine and yohimbane
Fulltext Access 7 Pages 2005
Graphical contents list
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Relationship between local electrophilicity and rate coefficients for the hydrolysis of carbenium ions
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New biologically active linear triterpenes from the bark of three new-caledonian Cupaniopsis species
Fulltext Access 7 Pages 2005
Graphical contents list
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A direct intramolecular asymmetric catalytic aldol cyclodehydration of meso-3,4-disubstituted-1,6-dialdehydes
Fulltext Access 7 Pages 2005
One pot solid phase synthesis of 2-substituted 2,3-dihydropyridin-4(1H)-ones on Rinkamide-resin
Fulltext Access 7 Pages 2005
Design and synthesis of an isopenicillin N synthase mimic
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Synthesis, thermal reactivity and kinetics of substituted [(benzoyl)(phenylcarbamoyl)methylene]triphenylphosphoranes and their thiocarbamoyl analogues
Fulltext Access 7 Pages 2005
9,9-Dimethyl-8,10-dioxapentacyclo[5.3.0.02,5.03,5.03,6]decane and naphthotetracyclo[5.1.0.01,6.02,7]oct-3-ene: new substituted [1.1.1]propellanes as precursors to 1,2,3,4-tetrafunctionalized bicyclo[1.1.1]pentanes
Fulltext Access 7 Pages 2005
Solvation-dependent diastereofacial selectivity: addition of lithioacetonitrile to 2-phenyl propanal
Fulltext Access 7 Pages 2005
Storage and transmission of microarray images
Fulltext Access 7 Pages 2005
Emerging role of high-density lipoprotein in the prevention of cardiovascular disease
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Biology calls the targets: combining RNAi and disease biology
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On time-space of nonlinear phenomena with Gompertzian dynamics
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Higher mutation rate helps to rescue genes from the elimination by selection
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Evolutionary history of the retinoblastoma gene from archaea to eukarya
Fulltext Access 7 Pages 2005
Molecular mechanisms in the inherited red cell membrane disorders
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The genetics of dominant osteopetrosis
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Mechanisms of WHIM syndrome
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Mechanisms of dominant congenital neutropenias
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Recent advances in our understanding of Parkinson's disease
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Genetics and mechanisms of disease in Rett syndrome
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Interdisciplinary research and education at the biology-engineering-computer science interface: a perspective (reprinted article)
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Regio- and stereoselective synthesis of Z-vinylic tellurides from propargylic alcohols: a route to chiral Z-enynes
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Essential properties of drug-targeting delivery systems
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Information maximization for exploring neural coding in hippocampus and lateral septum
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Natural scene statistics and nonlinear neural interactions between frequency-selective mechanisms
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Synchronization with low power consumption of hardware models of cardiac cells
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Synthesis of the benzo-β-carboline isoneocryptolepine: the missing indoloquinoline isomer in the alkaloid series cryptolepine, neocryptolepine and isocryptolepine
Fulltext Access 7 Pages 2005
Synthesis and characterization of ferrocene-perylenetetracarboxylic diimide-fullerene triad
Fulltext Access 7 Pages 2005
The consecutive [2+2] cycloaddition-ring expansion route to diastereomeric 1,4-diazepin-5-ones from imino-ketenimines. Alternative intramolecular transamidation of β-lactams
Fulltext Access 7 Pages 2005
Selective microwave-accelerated synthesis and polymerization of chiral methacrylamide directly from methacrylic acid and (R)-1-phenyl-ethylamine
Fulltext Access 7 Pages 2005
Reaction of tricarbonyl[(1-4-η)-2-methoxy-5-vinylidene-cyclohexa-1,3-diene]iron derivatives with carbene: (2+1) cycloaddition for the rapid synthesis of spiro[2,5]octane
Fulltext Access 7 Pages 2005
Chemical transformation of Baylis-Hillman adducts: the reaction of methyl 3-arylamino-2-methylene-3-phenylpropanoates in polyphosphoric acid
Fulltext Access 7 Pages 2005
Graphical contents list
Fulltext Access 7 Pages 2005
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