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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

New diterpenoids from stems and roots of Caesalpinia crista
Fulltext Access 7 Pages 2005
Electron deficiency of aldehydes controls the pyrrolidine catalyzed direct cross-aldol reaction of aromatic/heterocyclic aldehydes and ketones in water
Fulltext Access 7 Pages 2005
A new dimeric bidentated NHC-Pd(II) complex from trans-cyclohexane-1,2-diamine for Suzuki reaction and Heck reaction
Fulltext Access 7 Pages 2005
Investigations into the selective oxidation of vicinal diols to α-hydroxy ketones with the NaBrO3/NaHSO3 reagent: pH dependence, stoichiometry, substrates and origin of selectivity
Fulltext Access 7 Pages 2005
Tri-component reaction of 2-alkyl-4,5-dichloropyridazin-3(2H)-ones: synthesis of 5-cyano-5-(pyrimidin-2-yl)-2,7-dialkyl-5H-dipyridazino-[4,5-b:4,5-e]-4H-thiopyran-1,6-dione and 2-(4-cyanophenoxy) pyrimidine
Fulltext Access 7 Pages 2005
Synthesis of 2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-ones by the domino Michael addition retro-ene reaction of 2-alkoxyiminoimidazolidines and acetylene carboxylates
Fulltext Access 7 Pages 2005
Pd2(dba)3/Xantphos-catalyzed cross-coupling of thiols and aryl bromides/triflates
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Syntheses and optoelectronic properties of four photochromic dithienylethenes
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Oxidative coupling of methoxynaphthylenediols
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Biselides A-E: novel polyketides from the Okinawan ascidian Didemnidae sp.
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Concise and diastereoselective approach to syn- and anti-N-tosyl-α-hydroxy β-amino acid derivatives
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Polyhydroxylated pyrrolizidines. Part 6: A new and concise stereoselective synthesis of (+)-casuarine and its 6,7-diepi isomer, from DMDP
Fulltext Access 7 Pages 2005
Synthesis, antitumor and DNA photocleaving activities of novel naphthalene carboxamides: effects of different thio-heterocyclic rings and aminoalkyl side chains
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Chlorodinitrophenylhydrazine, a useful crystalline agent for absolute configuration determination of various chiral ketones
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The fluoride ion-induced intramolecular conjugate addition of propargylsilanes to dihydropyridones. A novel method for the stereoselective construction of azabicyclic ring systems
Fulltext Access 7 Pages 2005
Graphical contents list
Fulltext Access 7 Pages 2005
Efficient synthesis of analogs of safflower yellow B, carthamin, and its precursor: two yellow and one red dimeric pigments in safflower petals
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The conversion of pentoses to 3,4-dihydroxyprolines
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Synthesis and conformational studies of amide-linked cyclic homooligomers of a thymidine-based nucleoside amino acid
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Salt, concentration, and temperature effects on an asparagine-based, aqueous Diels-Alder cycloaddition
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Carboxylic acids as promoters for internucleotide-bond formation via condensation of a nucleoside phosphoramidite and a nucleoside: relationship between the acidity and the activity of the promoter
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Development of resin-to-resin transfer reactions (RRTR) using Sonogashira chemistry
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Concise total synthesis of (3Z,6Z,9S,10R)-9,10-epoxy-1,3,6-heneicosatriene, sex pheromone component of Hyphantria Cunea
Fulltext Access 7 Pages 2005
Studies on solid-state proton transfer along hydrogen bond of pyrazolone-ring
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Microwave-assisted one-pot regioselective synthesis of 2-alkyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazines
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Synthesis of all 7αH-guaia-4,11-dien-3-one diastereomers from (+)-dihydrocarvone
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Controlled transdermal delivery of model drug compounds by MEMS microneedle array
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Artemisinin inhibits cation currents in malaria-infected human erythrocytes
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Effects of single-walled carbon nanotubes on the functions of plasma proteins and potentials in vascular prostheses
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Quantum dot-mediated biosensing assays for specific nucleic acid detection
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Highlights of the first annual meeting of the American Academy of Nanomedicine
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Investigation of angiotensin II type 1 receptor by atomic force microscopy with functionalized tip
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Surfactant effects on carbon nanotube interactions with human keratinocytes
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An evanescent approach for mitochondrial function assay of living cells
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Topological models for the prediction of HIV-protease inhibitory activity of tetrahydropyrimidin-2-ones
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Homology modelling of RNA polymerase and associated transcription factors from Bacillus subtilis
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Practical synthesis of d-[1-13C]mannose, l-[1-13C] and l-[6-13C]fucose
Fulltext Access 7 Pages 2005
Graphical contents list
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Synthesis of spirane-bridged rigidified oxalkyl cyclopentadienyl ligands
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Highly regio- and stereocontrolled SN2′ reactions of gem-difluorinated vinyloxiranes with monoalkylcopper reagents
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Facile preparation of organozinc bromides using electrogenerated highly reactive zinc and its use in cross-coupling reaction
Fulltext Access 7 Pages 2005
Graphical contents list
Fulltext Access 7 Pages 2005
First enantiospecific synthesis of (+)-β-herbertenol
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Reductive ring opening of cis- and trans-2,3-diphenyloxirane: a common intermediate
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Trihydroxy-2-thiaquinolizidine derivatives as a new class of bicyclic glycosidase inhibitors
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Synthesis of annelated [a]aza-anthracenones and thieno[3,2-g]aza-naphthalenones through ring transformation of 2H-pyran-2-one followed by photocyclization
Fulltext Access 7 Pages 2005
Stereoselective synthesis of (3S,4S)-tert-butyl-N-Boc-3-ethyl-4-hydroxy-l-prolinate and (3S,4R)-tert-butyl-N-Boc-3-ethyl-4-hydroxy-l-prolinate
Fulltext Access 7 Pages 2005
The geometric isomers of methyl-2,4,6-decatrienoate, including pheromones of at least two species of stink bugs
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A 1H NMR study on the complexation of tetraalkylammonium cations, mono and diprotonated amines, and amino acids with a derivatized cyclotetrachromotropylene in an aqueous solution
Fulltext Access 7 Pages 2005
Efficient incorporation of 1-(2-deoxy-β-d-ribofuranosyl)-2-oxo-imidazole-4-carboxamide into DNA via a suitable convertible phosphoramidite derivative
Fulltext Access 7 Pages 2005
Synthesis and electrochemical characterization of dipyrroles separated by diphenyleneoxide and diphenylenesulfide spacers via the Trofimov reaction
Fulltext Access 7 Pages 2005
A novel base-promoted synthesis of β-indolylketones via a three-component condensation under ultrasonic irradiation
Fulltext Access 7 Pages 2005
Sesquiterpenoids from Ligularia virgaurea spp. oligocephala
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Facile one-pot synthesis of BINOL- and H8-BINOL-based aryl phosphites and their use in palladium catalysed asymmetric allylation
Fulltext Access 7 Pages 2005
Gas-phase thermolysis of 1-acylnaphtho[1,8-de][1,2,3]triazines. Interesting direct routes towards condensed naphtho[1,8-de]heterocyclic ring systems
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Intermolecular reductive coupling of hindered N-aryl imines towards the modular synthesis of chiral N-heterocyclic carbenes
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Synthesis of 2-methyl-4-methoxydiphenylamine by palladium catalyzed C-N coupling-high synthetic versatility by use of a flexible catalytic system
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Practical application of new catalytic methods: a concise synthesis of a potent PDE IV inhibitor
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A highly diastereoselective synthesis of 3-carbethoxy-2,5-disubstituted-3-pyrrolines by phosphine catalysis
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Enantioselective synthesis of β-amino alcohols and α-amino acids via a copper catalyzed addition of diorganozinc reagents to N-phosphinoylimines
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Three-component synthesis of polysubstituted benzene derivatives via Diels–Alder reaction of cyclopentadienone acetal with alkyne
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Indium (III) mediated Markovnikov addition of malonates and β-ketoesters to terminal alkynes and the formation of Knoevenagel condensation products
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On-resin cyclization of a head-to-tail cyclopeptide using an allyldimethylsilyl polystyrene resin pre-loaded by metathesis
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Preparation and photoluminescence of p-terphenyl derivatives containing cyano groups
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Synthesis of ketene phenyl- and butyltelluroacetals by a Horner-Wittig route
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Acremines A-F, novel secondary metabolites produced by a strain of an endophytic Acremonium, isolated from sporangiophores of Plasmopara viticola in grapevine leaves
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Efficient lipase-catalyzed synthesis of new lipid antioxidants based on a catechol structure
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Graphical contents list
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Polymer-bound diazonium salts for the synthesis of diazoacetic esters
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Synthesis and utilization of functionalized polystyrene resins
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PEG-supported pyridylthioesters for racemization-free amide synthesis: a reagent that allows simultaneous product formation and removal from the polymer
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High-load, soluble oligomeric benzenesulfonyl azide: application to facile diazo-transfer reactions
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Asymmetric Mukaiyama aldol reaction of silyl enol ethers with aldehydes using a polymer-supported chiral Lewis acid catalyst
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Aerobic oxidation of alcohols to carbonyl compounds mediated by poly(ethylene glycol)-supported TEMPO radicals
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Optimization of polystyrene-supported triphenylphosphine catalysts for aza-Morita-Baylis-Hillman reactions
Fulltext Access 7 Pages 2005
Further rearranged prenylxanthones and benzophenones from Garcinia bracteata
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Concise syntheses of 2-aminoindans via indan-2-ol
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Lanthanide complexes of new polyaminocarboxylate complexes with two chromophores derived from bispyrazolylpyridine and aceto or benzophenone: synthesis, characterization and photophysical properties
Fulltext Access 7 Pages 2005
Cytotoxic dimeric sesquiterpenoids from Curcuma parviflora: isolation of three new parviflorenes and absolute stereochemistry of parviflorenes A, B, D, F, and G
Fulltext Access 7 Pages 2005
Synthesis and reactions of a monosubstituted dithiirane 1-oxide, 3-(9-triptycyl)dithiirane 1-oxide
Fulltext Access 7 Pages 2005
Effective consideration of ring structures in CAST/CNMR for highly accurate 13C NMR chemical shift prediction
Fulltext Access 7 Pages 2005
A DFT study of the polar Diels-Alder reaction between 4-aza-6-nitrobenzofuroxan and cyclopentadiene
Fulltext Access 7 Pages 2005
Graphical contents list
Fulltext Access 7 Pages 2005
Hydrogen-bonding-induced oligoanthranilamide foldamers. Synthesis, characterization, and complexation for aliphatic ammonium ions
Fulltext Access 7 Pages 2005
Synthesis of photolabile o-nitroveratryloxycarbonyl (NVOC) protected peptide nucleic acid monomers
Fulltext Access 7 Pages 2005
Stereoselective synthesis of optically active mono and diaminoalcohols
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New C2-symmetric 2,2′-bipyridine crown macrocycles for enantioselective recognition of amino acid derivatives
Fulltext Access 7 Pages 2005
Graphical contents list
Fulltext Access 7 Pages 2005
Graphical contents list
Fulltext Access 7 Pages 2005
Highly enantioselective synthesis and potential biological activity of chiral novel nucleoside analogues containing adenine and naturally phenol derivatives
Fulltext Access 7 Pages 2005
Structures of sym-(R)dibenzo-16-crown-5-oxyacetic acids and their alkali metal cation binding
Fulltext Access 7 Pages 2005
Tetrahedron reports on organic chemistry author index
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Synthesis and properties of coumarin-derived organogelators
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A concise sequential photochemical-metathesis approach for the synthesis of (+)-castanospermine and possible uniflorine-A stereoisomers
Fulltext Access 7 Pages 2005
A convenient and new approach to the synthesis of ω-heterocyclic amino acids from carboxy lactams through ring-chain-transformation. Part 2: Synthesis of (2R)-/(2S)-2-aminomethyl-3-(1-aryl-/1,5-diaryl-1H-pyrazol-3-yl)-propionic acid
Fulltext Access 7 Pages 2005
Synthesis and reactions of 3-alkylsulfanyl-1,3-dihydro-2,1-benzisothiazole 2,2-dioxides
Fulltext Access 7 Pages 2005
Glucofuranose derivatives as a library for designing and investigating low molecular mass organogelators
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Graphical contents list
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Substrate-selective aqueous organometallic catalysis. How small water-soluble organic molecules enhance the supramolecular discrimination
Fulltext Access 7 Pages 2005
Pyridazine derivatives. Part 40: Reactivity of 5-alkynylpyridazin-3(2H)-ones toward hydrochloric acid
Fulltext Access 7 Pages 2005
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