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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Cardioprotection of Sheng Mai Yin a classic formula on adriamycin induced myocardial injury in Wistar rats
Fulltext Access 11 Pages 2018
Drug transport mechanisms and in vitro release kinetics of vancomycin encapsulated chitosan-alginate polyelectrolyte microparticles as a controlled drug delivery system
Fulltext Access 11 Pages 2018
Contents (graphical abstracts and research highlights)
Fulltext Access 11 Pages 2018
Mannose-functionalized solid lipid nanoparticles are effective in targeting alveolar macrophages
Fulltext Access 11 Pages 2018
Synthetic approaches to phomactins: Novel oxidation of homoallylic alcohols using tetra-n-propylammonium perruthenate
Fulltext Access 11 Pages 2018
Coumarins with an unprecedented tetracyclic skeleton and coumarin dimers from chemically engineered extracts of a marine-derived fungus
Fulltext Access 11 Pages 2018
A new approach for the total synthesis of spilanthol and analogue with improved anesthetic activity
Fulltext Access 11 Pages 2018
An extension of nickel-catalyzed reductive coupling between tertiary alkyl halides with allylic carbonates
Fulltext Access 11 Pages 2018
Tacrolimus: An updated review on delivering strategies for multifarious diseases
Fulltext Access 11 Pages 2018
Aminothiazoles and aminothiadiazoles as nucleophiles in aminocarbonylation of iodobenzene derivatives
Fulltext Access 11 Pages 2018
A new approach to the synthesis of lactams of muramic, isomuramic and normuramic acids via intramolecular O-alkylation: Stereochemical features of the intramolecular nucleophilic substitution
Fulltext Access 11 Pages 2018
The natural and synthetic indole weaponry against bacteria
Fulltext Access 11 Pages 2018
Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis
Fulltext Access 11 Pages 2018
Strategic R&D transactions in personalized drug development
Fulltext Access 11 Pages 2018
Physical exercise prevents cognitive impairment by enhancing hippocampal neuroplasticity and mitochondrial function in doxorubicin-induced chemobrain
Fulltext Access 11 Pages 2018
Improving sustained drug delivery from ophthalmic lens materials through the control of temperature and time of loading
Fulltext Access 11 Pages 2018
Aggressive conditions during primary drying as a contemporary approach to optimise freeze-drying cycles of biopharmaceuticals
Fulltext Access 11 Pages 2018
Neurotransmitters in the mediation of cerebral ischemic injury
Fulltext Access 11 Pages 2018
Market entry, power, pharmacokinetics: what makes a successful drug innovation?
Fulltext Access 11 Pages 2018
Preparation and evaluation of clindamycin phosphate loaded chitosan/alginate polyelectrolyte complex film as mucoadhesive drug delivery system for periodontal therapy
Fulltext Access 11 Pages 2018
Demonstrating significant benefit of orphan medicines: analysis of 15 years of experience in Europe
Fulltext Access 11 Pages 2018
Effectiveness of pharmacopuncture for cervical spondylosis: A systematic review and meta-analysis
Fulltext Access 11 Pages 2018
The importance of differentiating the three modalities of Tai Chi Chuan practice in clinical trials - A critical review
Fulltext Access 11 Pages 2018
Synthesis of steroidal imidazolidinthiones as potential apoptotic agents: Investigation by theoretical and experimental studies
Fulltext Access 11 Pages 2018
Advances in paper-analytical methods for pharmaceutical analysis
Fulltext Access 11 Pages 2018
Somatostatin Receptor-Mediated Specific Delivery of Paclitaxel Prodrugs for Efficient Cancer Therapy
Fulltext Access 11 Pages 2018
The pharyngeal recess/Eustachian tube complex forms an acoustic passageway
Fulltext Access 11 Pages 2018
Molecular dynamics simulation for rational protein engineering: Present and future prospectus
Fulltext Access 11 Pages 2018
Computational assessment of thioether isosteres
Fulltext Access 11 Pages 2018
Identification of novel and selective non-peptide inhibitors targeting the polo-box domain of polo-like kinase 1
Fulltext Access 11 Pages 2018
Poly(2-Ethyl-2-Oxazoline) as an Alternative to Poly(Vinylpyrrolidone) in Solid Dispersions for Solubility and Dissolution Rate Enhancement of Drugs
Fulltext Access 11 Pages 2018
Development and Characterization of Gastroretentive High-Density Pellets Lodged With Zero Valent Iron Nanoparticles
Fulltext Access 11 Pages 2018
Anti-inflammatory hybrids of secondary amines and amide-sulfamide derivatives
Fulltext Access 11 Pages 2018
Assessment of Intragranular and Extragranular Fracture in the Development of Tablet Tensile Strength
Fulltext Access 11 Pages 2018
Investigation of Metal-Catalyzed Antibody Carbonylation With an Improved Protein Carbonylation Assay
Fulltext Access 11 Pages 2018
The recent progress of isoxazole in medicinal chemistry
Fulltext Access 11 Pages 2018
Formulation and evaluation of selected transmucosal dosage forms containing a double fixed-dose of acyclovir and ketoconazole
Fulltext Access 11 Pages 2018
Synthesis and anti-influenza virus evaluation of triterpene-sialic acid conjugates
Fulltext Access 11 Pages 2018
Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition
Fulltext Access 11 Pages 2018
Free radical rearrangement synthesis and microbiological evaluation of novel 2-sulfoether-4-quinolone scaffolds as potential antibacterial agents
Fulltext Access 11 Pages 2018
Anti-inflammatory effects of flavonoids in neurodegenerative disorders
Fulltext Access 11 Pages 2018
Prophylactic use of colchicine in preventing radiation induced coronary artery disease
Fulltext Access 12 Pages 2018
Contributions of medial prefrontal cortex to decision making involving risk of punishment
Fulltext Access 12 Pages 2018
The arteriolar injury in hypertension
Fulltext Access 12 Pages 2018
High risk for neural tube defects; the role of arsenic in drinking water and rice in Asia
Fulltext Access 12 Pages 2018
The origin of endometriosis-associated ovarian cancer from uterine neoplastic lesions
Fulltext Access 12 Pages 2018
Solid lipid nanoparticles modified with amphipathic chitosan derivatives for improved stability in the gastrointestinal tract
Fulltext Access 12 Pages 2018
Enhanced central histaminergic transmission attenuates compulsive-like behavior in mice
Fulltext Access 12 Pages 2018
Injectable Hydrogels for Localized Chemotherapy and Radiotherapy in Brain Tumors
Fulltext Access 12 Pages 2018
Medium chain triglyceride diet reduces anxiety-like behaviors and enhances social competitiveness in rats
Fulltext Access 12 Pages 2018
Cannabinoid receptor-mediated disruption of sensory gating and neural oscillations: A translational study in rats and humans
Fulltext Access 12 Pages 2018
Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review
Fulltext Access 12 Pages 2018
Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays
Fulltext Access 12 Pages 2018
Post-translational dysfunctions in channelopathies of the nervous system
Fulltext Access 12 Pages 2018
Light-actuated resorcin[4]arene cavitands
Fulltext Access 12 Pages 2018
Synthesis and biological evaluation of novel benzofuroxan-based pyrrolidine hydroxamates as matrix metalloproteinase inhibitors with nitric oxide releasing activity
Fulltext Access 12 Pages 2018
Mucus protectors: Promising therapeutic strategies for inflammatory bowel disease
Fulltext Access 12 Pages 2018
Modeling of complex signals in nerve fibers
Fulltext Access 12 Pages 2018
Novel indoline dye tetrabutylammonium carboxylates attached with a methyl group on the cyclopentane ring for dye-sensitized solar cells
Fulltext Access 12 Pages 2018
Bioinformatics-based tools in drug discovery: the cartography from single gene to integrative biological networks
Fulltext Access 12 Pages 2018
Past, Present, and Future of Bioequivalence: Improving Assessment and Extrapolation of Therapeutic Equivalence for Oral Drug Products
Fulltext Access 12 Pages 2018
Graphical contents list
Fulltext Access 12 Pages 2018
Unexpected effect of cyclodepsipeptides bearing a sulfonylhydrazide moiety towards histone deacetylase activity
Fulltext Access 12 Pages 2018
Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents
Fulltext Access 12 Pages 2018
Route design, the foundation of successful chemical development
Fulltext Access 12 Pages 2018
An efficient synthesis of multisubstituted 4-nitrobuta-1,3-dien-1-amines and application in cyclisation reactions
Fulltext Access 12 Pages 2018
Synthesis and study of the antimalarial cardamom peroxide
Fulltext Access 12 Pages 2018
Thioether macrocycles of the microbisporicins via reductive desulfurization
Fulltext Access 12 Pages 2018
Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease
Fulltext Access 12 Pages 2018
Immunoproteasome inhibition and bioactivity of thiasyrbactins
Fulltext Access 12 Pages 2018
Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout
Fulltext Access 12 Pages 2018
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease
Fulltext Access 12 Pages 2018
Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases
Fulltext Access 12 Pages 2018
Combining prolinamides with 2-pyrrolidinone: Novel organocatalysts for the asymmetric aldol reaction
Fulltext Access 12 Pages 2018
Experimental and computational modeling of interaction of kolaviron-kolaflavanone with aldehyde dehydrogenase
Fulltext Access 12 Pages 2018
Benzimidazole scaffold based hybrid molecules for various inflammatory targets: Synthesis and evaluation
Fulltext Access 12 Pages 2018
Magnetic nanoparticles modified-porous scaffolds for bone regeneration and photothermal therapy against tumors
Fulltext Access 12 Pages 2018
Lithium doped silica nanospheres/poly(dopamine) composite coating on polyetheretherketone to stimulate cell responses, improve bone formation and osseointegration
Fulltext Access 12 Pages 2018
Comparative modeling and molecular docking analysis of white, brown and soft rot fungal laccases using lignin model compounds for understanding the structural and functional properties of laccases
Fulltext Access 12 Pages 2018
Exploring the binding mechanisms of diaminopimelic acid analogs to meso-diaminopimelate dehydrogenase by molecular modeling
Fulltext Access 12 Pages 2018
Ziprasidone nanocrystals by wet media milling followed by spray drying and lyophilization: Formulation and process parameter optimization
Fulltext Access 12 Pages 2018
Evaluation of critical parameters for in vitro skin permeation and penetration studies using animal skin models
Fulltext Access 12 Pages 2018
A bibliometric review of drug repurposing
Fulltext Access 12 Pages 2018
Impact of Superdisintegrants and Film Thickness on Disintegration Time of Strip Films Loaded With Poorly Water-Soluble Drug Microparticles
Fulltext Access 12 Pages 2018
Intradermal Delivery of a Near-Infrared Photosensitizer Using Dissolving Microneedle Arrays
Fulltext Access 12 Pages 2018
Renal organic anion transporters in drug-drug interactions and diseases
Fulltext Access 12 Pages 2018
Electrohydrodynamic methods for the development of pulmonary drug delivery systems
Fulltext Access 12 Pages 2018
Improved vaginal retention and enhanced antifungal activity of miconazole microsponges gel: Formulation development and in vivo therapeutic efficacy in rats
Fulltext Access 12 Pages 2018
Improvement of Tenofovir vaginal release from hydrophilic matrices through drug granulation with hydrophobic polymers
Fulltext Access 12 Pages 2018
Novel therapeutic drug identification and gene correlation for fatty liver disease using high-content screening: Proof of concept
Fulltext Access 12 Pages 2018
Overcoming the resistance mechanisms of Smoothened inhibitors
Fulltext Access 12 Pages 2018
Comparative Assessment of Miniaturized Screening Approaches for Selection of Polymers for Amorphous Drug Stabilization
Fulltext Access 12 Pages 2018
Cancer theranostic applications of lipid-based nanoparticles
Fulltext Access 12 Pages 2018
Recent advances in near-infrared light-responsive nanocarriers for cancer therapy
Fulltext Access 12 Pages 2018
Opportunities and pitfalls in clinical proof-of-concept: principles and examples
Fulltext Access 12 Pages 2018
Light-triggerable formulations for the intracellular controlled release of biomolecules
Fulltext Access 12 Pages 2018
Dual-therapy strategy for modification of adiponectin receptor signaling in aging-associated chronic diseases
Fulltext Access 12 Pages 2018
The remarkable therapeutic potential of response-based dose individualisation in drug trials and patient care
Fulltext Access 12 Pages 2018
Turn-on fluorescence sensor for mono- and di-phosphonic acid derivatives using anthracene-based diamidine and its detection of amidinium-phosphonate and amidinium formation
Fulltext Access 12 Pages 2018
Design of a fused triazolyl 2-quinolinone unnatural nucleoside via tandem CuAAC-Ullmann coupling reaction and study of photophysical property
Fulltext Access 12 Pages 2018
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