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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Renal organic anion transporters in drug-drug interactions and diseases
Fulltext Access 12 Pages 2018
Neuromuscular taping reduces blood pressure in systemic arterial hypertension
Fulltext Access 13 Pages 2018
Natural compounds and combination therapy in colorectal cancer treatment
Fulltext Access 13 Pages 2018
Urokinase receptor derived peptides as potent inhibitors of the formyl peptide receptor type 1-triggered cell migration
Fulltext Access 13 Pages 2018
Triaryl-substituted pyrrolo-p-phenylene-linked porphyrin-fullerene dyads: Expanding the structural diversity of photoactive materials
Fulltext Access 13 Pages 2018
Simplified beta-glycosylation of peptides
Fulltext Access 13 Pages 2018
The cerebral collateral circulation: Relevance to pathophysiology and treatment of stroke
Fulltext Access 13 Pages 2018
Synthetic application of water-soluble hypervalent iodine reagents in aqueous media
Fulltext Access 13 Pages 2018
Functional nanomachines: Recent advances in synthetic molecular machinery
Fulltext Access 13 Pages 2018
Propranolol produces short-term facilitation of extinction in a rabbit model of post-traumatic stress disorder
Fulltext Access 13 Pages 2018
How prokaryotes 'encode' their environment: Systemic tools for organizing the information flow
Fulltext Access 13 Pages 2018
Disturbed purine nucleotide metabolism in chronic kidney disease is a risk factor for cognitive impairment
Fulltext Access 13 Pages 2018
Protein-peptide docking: opportunities and challenges
Fulltext Access 13 Pages 2018
A tumor multicomponent targeting chemoimmune drug delivery system for reprograming the tumor microenvironment and personalized cancer therapy
Fulltext Access 13 Pages 2018
Impulsive mechanisms influencing relapse in alcohol drinking
Fulltext Access 13 Pages 2018
Nanomedicine safety in preclinical and clinical development: focus on idiosyncratic injection/infusion reactions
Fulltext Access 13 Pages 2018
Calpastatin ablation aggravates the molecular phenotype in cell and animal models of Huntington disease
Fulltext Access 13 Pages 2018
Visualizing convolutional neural network protein-ligand scoring
Fulltext Access 13 Pages 2018
A new hypothesis for the pathophysiology of complex regional pain syndrome
Fulltext Access 13 Pages 2018
Big data vs accurate data in health research: Large-scale physical activity monitoring, smartphones, wearable devices and risk of unconscious bias
Fulltext Access 13 Pages 2018
Computational drug repositioning for rare diseases in the era of precision medicine
Fulltext Access 13 Pages 2018
Drug target residence time: a misleading concept
Fulltext Access 13 Pages 2018
Alternative Manufacturing Concepts for Solid Oral Dosage Forms From Drug Nanosuspensions Using Fluid Dispensing and Forced Drying Technology
Fulltext Access 13 Pages 2018
Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer
Fulltext Access 13 Pages 2018
Development and Characterization of Chitosan Cross-Linked With Tripolyphosphate as a Sustained Release Agent in Tablets, Part I: Design of Experiments and Optimization
Fulltext Access 13 Pages 2018
The effect of religious intervention on the level of consciousness of comatose patients hospitalized in an intensive care unit: a randomized clinical trial
Fulltext Access 13 Pages 2018
Merits and Limitations of Dynamic Vapor Sorption Studies on the Morphology and Physicochemical State of Freeze-Dried Products
Fulltext Access 13 Pages 2018
Curcumin drug delivery by vanillin-chitosan coated with calcium ferrite hybrid nanoparticles as carrier
Fulltext Access 13 Pages 2018
A novel approach for skin infections: Controlled release topical mats of poly(lactic acid)/poly(ethylene succinate) blends containing Voriconazole
Fulltext Access 13 Pages 2018
Synthesis and leishmanicidal activity of eugenol derivatives bearing 1,2,3-triazole functionalities
Fulltext Access 13 Pages 2018
Comparision of the efficacy of neural therapy versus steroid injection in the treatment of lateral epicondylitis (tennis elbow)
Fulltext Access 13 Pages 2018
Large supramolecular structures of 33-mer gliadin peptide activate toll-like receptors in macrophages
Fulltext Access 13 Pages 2018
Nano- and micro-materials in the treatment of internal bleeding and uncontrolled hemorrhage
Fulltext Access 13 Pages 2018
Polymer hydration and stiffness at biointerfaces and related cellular processes
Fulltext Access 13 Pages 2018
Current approaches to the discovery of novel inhaled medicines
Fulltext Access 13 Pages 2018
Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase
Fulltext Access 13 Pages 2018
Development of a new doubly-labeled fluorescent ceramide probe for monitoring the metabolism of sphingolipids in living cells
Fulltext Access 13 Pages 2018
Conventional and microwave prompted synthesis, antioxidant, anticholinesterase activity screening and molecular docking studies of new quinolone-triazole hybrids
Fulltext Access 13 Pages 2018
Synthesis and structure-activity relationship study of multi-target triazine derivatives as innovative candidates for treatment of Alzheimer's disease
Fulltext Access 13 Pages 2018
Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors
Fulltext Access 13 Pages 2018
Syntheses and structure-activity relationships on antibacterial and anti-ulcerative colitis properties of quaternary 13-substituted palmatines and 8-oxo-13-substituted dihydropalmatines
Fulltext Access 13 Pages 2018
Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids
Fulltext Access 13 Pages 2018
Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles
Fulltext Access 13 Pages 2018
Synthesis and biological evaluation of magnolol derivatives as melatonergic receptor agonists with potential use in depression
Fulltext Access 13 Pages 2018
Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents
Fulltext Access 13 Pages 2018
Relevance of tissue specific subunit expression in channelopathies
Fulltext Access 13 Pages 2018
Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review
Fulltext Access 13 Pages 2018
Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation
Fulltext Access 13 Pages 2018
Discovery of phenylsulfonylfuroxan derivatives as gamma globin inducers by histone acetylation
Fulltext Access 13 Pages 2018
A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities
Fulltext Access 13 Pages 2018
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy
Fulltext Access 13 Pages 2018
Incorporation of histone deacetylase inhibitory activity into the core of tamoxifen - A new hybrid design paradigm
Fulltext Access 13 Pages 2018
Human carboxylesterases: a comprehensive review
Fulltext Access 14 Pages 2018
Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory
Fulltext Access 14 Pages 2018
Amphipathic sulfonamidobenzamides mimicking small antimicrobial marine natural products; investigation of antibacterial and anti-biofilm activity against antibiotic resistant clinical isolates
Fulltext Access 14 Pages 2018
Modified in vitro release of the chronobiotic hormone melatonin from matrix tablets based on the marine sulfated polysaccharide ulvan
Fulltext Access 14 Pages 2018
Iron released from reactive microglia by noggin improves myelin repair in the ischemic brain
Fulltext Access 14 Pages 2018
Interfering peptides targeting protein-protein interactions: the next generation of drugs?
Fulltext Access 14 Pages 2018
Challenges and Opportunities for the Subcutaneous Delivery of Therapeutic Proteins
Fulltext Access 14 Pages 2018
Naphthalene dianhydride based selective detection targetable fluorescent probe for monitoring exogenous Iron in living cells
Fulltext Access 14 Pages 2018
Curcumin Cocrystal Micelles-Multifunctional Nanocomposites for Management of Neurodegenerative Ailments
Fulltext Access 14 Pages 2018
Heat shock protein(s) may serve as estrus indicators in animals: A conceptual hypothesis
Fulltext Access 14 Pages 2018
Clinical features of a fatal shoulder dystocia: The hypovolemic shock hypothesis
Fulltext Access 14 Pages 2018
The pathology and pathophysiology of vascular dementia
Fulltext Access 14 Pages 2018
Evaluation of Glass Delamination Risk in Pharmaceutical 10 mL/10R Vials
Fulltext Access 14 Pages 2018
Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease
Fulltext Access 14 Pages 2018
Contents (graphical abstracts and research highlights)
Fulltext Access 14 Pages 2018
Recent topics of radical-based carbon-carbon bond formations
Fulltext Access 14 Pages 2018
A highly integrated precision nanomedicine strategy to target esophageal squamous cell cancer molecularly and physically
Fulltext Access 14 Pages 2018
Cytoprotective and antioxidant properties of organic selenides for the myelin-forming cells, oligodendrocytes
Fulltext Access 14 Pages 2018
Studies on the lipid-regulating mechanism of alisol-based compounds on lipoprotein lipase
Fulltext Access 14 Pages 2018
Molecular modelling and synthesis of spiroimidazolidine-2,4-diones with dual activities as hypoglycemic agents and selective inhibitors of aldose reductase
Fulltext Access 14 Pages 2018
Development of optimized conditions for Glaser-Hay bioconjugations
Fulltext Access 14 Pages 2018
Synthesis and biological properties of aryl methyl sulfones
Fulltext Access 14 Pages 2018
Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs
Fulltext Access 14 Pages 2018
Design, synthesis and biological evaluation of anti-pancreatic cancer activity of plinabulin derivatives based on the co-crystal structure
Fulltext Access 14 Pages 2018
New phenylaniline derivatives as modulators of amyloid protein precursor metabolism
Fulltext Access 14 Pages 2018
Lead identification and optimization of bacterial glutamate racemase inhibitors
Fulltext Access 14 Pages 2018
Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues
Fulltext Access 14 Pages 2018
Ciprofloxacin derivatives and their antibacterial activities
Fulltext Access 14 Pages 2018
Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents
Fulltext Access 14 Pages 2018
Non-enzyme entrapping biohydrogels in catalysis
Fulltext Access 14 Pages 2018
Melt extrusion process for adjusting drug release of poorly water soluble drug felodipine using different polymer matrices
Fulltext Access 14 Pages 2018
Evidence for the implication of the histone code in building the genome structure
Fulltext Access 14 Pages 2018
Reversal of epigenetic aberrations associated with the acquisition of doxorubicin resistance restores drug sensitivity in breast cancer cells
Fulltext Access 14 Pages 2018
Cupping therapy for treating ankylosing spondylitis: Protocol for a systematic review
Fulltext Access 14 Pages 2018
Human and mouse artificial chromosome technologies for studies of pharmacokinetics and toxicokinetics
Fulltext Access 14 Pages 2018
Locked nucleic acid: modality, diversity, and drug discovery
Fulltext Access 14 Pages 2018
Finding hidden treasures in old drugs: the challenges and importance of licensing generics
Fulltext Access 14 Pages 2018
Safinamide: a new hope for Parkinson's disease?
Fulltext Access 14 Pages 2018
What is precise pathophysiology in development of hypertension in pregnancy? Precision medicine requires precise physiology and pathophysiology
Fulltext Access 14 Pages 2018
Pharmaceutical nanocrystals: production by wet milling and applications
Fulltext Access 14 Pages 2018
Advances in glycosylation-mediated cancer-targeted drug delivery
Fulltext Access 14 Pages 2018
Carbon dots: emerging theranostic nanoarchitectures
Fulltext Access 14 Pages 2018
Dendrimer nanohybrid carrier systems: an expanding horizon for targeted drug and gene delivery
Fulltext Access 15 Pages 2018
Effect of Water on the Chemical Stability of Amorphous Pharmaceuticals: 2. Deamidation of Peptides and Proteins
Fulltext Access 15 Pages 2018
Computational drug repurposing to predict approved and novel drug-disease associations
Fulltext Access 15 Pages 2018
The hitchhiker's guide to the chemical-biological galaxy
Fulltext Access 15 Pages 2018
Asymmetric cyclopropanation reactions catalyzed by carbohydrate-based crown ethers
Fulltext Access 15 Pages 2018
Topics of 1,3-diphosphacyclobutane-2,4-diyl derivatives: Structural aspects and functionality of isolable heavier congeners of cyclobutane-1,3-diyl and the related molecules
Fulltext Access 15 Pages 2018
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