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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Quantitative Monitoring the Anti-Solvent Crystallization and Storage Process for Nandrolone by Near-Infrared Spectroscopy
Fulltext Access 32 Pages 2018
Synthesis and biological evaluation of Schizandrin derivatives as potential anti-cancer agents
Fulltext Access 32 Pages 2018
Fluoroquinolone derivatives and their anti-tubercular activities
Fulltext Access 32 Pages 2018
Synthesis and biological evaluation of a series of multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect
Fulltext Access 32 Pages 2018
Synthesis of 10-membered and larger rings via free radical methods
Fulltext Access 32 Pages 2018
Pathway-based gene-gene interaction network modelling to predict potential biomarkers of essential hypertension
Fulltext Access 32 Pages 2018
Evaluation of the promoting effect of soluble cyclodextrins in drug nail penetration
Fulltext Access 32 Pages 2018
Current strategies to streamline pharmacotherapy for older adults
Fulltext Access 32 Pages 2018
Dibucaine in Ionic-Gradient Liposomes: Biophysical, Toxicological, and Activity Characterization
Fulltext Access 32 Pages 2018
Urea Improves Stability of Inactivated Polio Vaccine Serotype 3 During Lyophilization and Storage in Dried Formulations
Fulltext Access 32 Pages 2018
Structure Determination and Characterization of a Family of Primary Alcohol Solvates
Fulltext Access 32 Pages 2018
Clinical ultrasound stimulating angiogenesis following drug-release from polymersomes on the ischemic zone for peripheral arterial occlusive disease
Fulltext Access 32 Pages 2018
A Small-Scale Process for Predicting Donnan and Volume Exclusion Effects During Ultrafiltration/Diafiltration Process Development
Fulltext Access 32 Pages 2018
Determination of Nonspherical Morphology of Doxorubicin-Loaded Liposomes by Atomic Force Microscopy
Fulltext Access 32 Pages 2018
Functional neurological symptom disorder (conversion disorder): A role for microglial-based plasticity mechanisms?
Fulltext Access 32 Pages 2018
The role of antimalarial quality in the emergence and transmission of resistance
Fulltext Access 32 Pages 2018
Cannabinoid type 2 receptors mediate a cell type-specific self-inhibition in cortical neurons
Fulltext Access 32 Pages 2018
Maternal nicotine exposure effects on adolescent learning and memory are abolished in alpha(α)2* nicotinic acetylcholine receptor-null mutant mice
Fulltext Access 32 Pages 2018
Animal toxins for channelopathy treatment
Fulltext Access 32 Pages 2018
Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction
Fulltext Access 32 Pages 2018
Metal-plant frameworks in nanotechnology: An overview
Fulltext Access 32 Pages 2018
Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes
Fulltext Access 32 Pages 2018
Synthesis and antikinetoplastid evaluation of bis(benzyl)spermidine derivatives
Fulltext Access 32 Pages 2018
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery
Fulltext Access 32 Pages 2018
Reversed isoniazids: Design, synthesis and evaluation against Mycobacterium tuberculosis
Fulltext Access 32 Pages 2018
Potential targets for therapeutic intervention and structure based vaccine design against Zika virus
Fulltext Access 32 Pages 2018
Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials
Fulltext Access 32 Pages 2018
Silver nanoparticles-based hydrogel: Characterization of material parameters for pressure ulcer dressing applications
Fulltext Access 33 Pages 2018
Antibacterial properties of Latarcin 1 derived cell-penetrating peptides
Fulltext Access 33 Pages 2018
Mechanochemically induced solid state transformations: The case of raloxifene hydrochloride
Fulltext Access 33 Pages 2018
Cell-based and pharmacological neurorestorative therapies for ischemic stroke
Fulltext Access 33 Pages 2018
Fast and non-invasive serum detection technology based on surface-enhanced Raman spectroscopy and multivariate statistical analysis for liver disease
Fulltext Access 33 Pages 2018
Gradient nanocomposite hydrogels for interface tissue engineering
Fulltext Access 33 Pages 2018
Rational design of liposomes for sustained release drug delivery of bevacizumab to treat ocular angiogenesis
Fulltext Access 33 Pages 2018
Enhanced antifungal activity of Ketoconazole using rose oil based novel microemulsion formulation
Fulltext Access 33 Pages 2018
Stem cell-based gene delivery mediated by cationic niosomes for bone regeneration
Fulltext Access 33 Pages 2018
High sensitive and multiple detection of acute myocardial infarction biomarkers based on a dual-readout immunochromatography test strip
Fulltext Access 33 Pages 2018
Pharmacokinetic studies of naproxen amides of some amino acid esters with promising colorectal cancer chemopreventive activity
Fulltext Access 33 Pages 2018
Improved Stability of Tuberculosis Drug Fixed-Dose Combination Using Isoniazid-Caffeic Acid and Vanillic Acid Cocrystal
Fulltext Access 33 Pages 2018
Predicting Solubility/Miscibility in Amorphous Dispersions: It Is Time to Move Beyond Regular Solution Theories
Fulltext Access 33 Pages 2018
A novel dressing for the combined delivery of platelet lysate and vancomycin hydrochloride to chronic skin ulcers: Hyaluronic acid particles in alginate matrices
Fulltext Access 33 Pages 2018
Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives
Fulltext Access 33 Pages 2018
Design, synthesis and biological evaluation of novel quinazoline-2,4-diones conjugated with different amino acids as potential chitin synthase inhibitors
Fulltext Access 33 Pages 2018
New selective cyclooxygenase-2 inhibitors from cyclocoumarol: Synthesis, characterization, biological evaluation and molecular modeling
Fulltext Access 33 Pages 2018
Prenylated flavonoids as potent phosphodiesterase-4 inhibitors from Morus alba: Isolation, modification, and structure-activity relationship study
Fulltext Access 33 Pages 2018
Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer cells
Fulltext Access 33 Pages 2018
Gastric fluid composition in a paediatric population: Age-dependent changes relevant for gastrointestinal drug disposition
Fulltext Access 33 Pages 2018
Gene therapy and editing: Novel potential treatments for neuronal channelopathies
Fulltext Access 33 Pages 2018
Zinc phthalocyanine encapsulated in polymer micelles as a potent photosensitizer for the photodynamic therapy of osteosarcoma
Fulltext Access 33 Pages 2018
A method for optical imaging and monitoring of the excretion of fluorescent nanocomposites from the body using artificial neural networks
Fulltext Access 33 Pages 2018
Pharmacological profile of mephedrone analogs and related new psychoactive substances
Fulltext Access 33 Pages 2018
Pharmacokinetics of pericyte involvement in small-molecular drug transport across the blood-brain barrier
Fulltext Access 33 Pages 2018
Development of probiotic-loaded microcapsules for local delivery: Physical properties, cell release and growth
Fulltext Access 33 Pages 2018
Finding order in chemical chaos - Continuing characterization of synthetic cannabinoid receptor agonists
Fulltext Access 33 Pages 2018
Melanin concentrating hormone modulates oxytocin-mediated marble burying
Fulltext Access 34 Pages 2018
Quality markers of animal medicinal materials: Correlative analysis of musk reveals distinct metabolic changes induced by multiple factors
Fulltext Access 34 Pages 2018
Omega-3 fatty acids moderate oxidative and proinflammatory events in experimental hepatotoxicity in Wistar rats: comparison with livolin
Fulltext Access 34 Pages 2018
Inhalational anesthetics accelerate desensitization of acid-sensing ion channels
Fulltext Access 34 Pages 2018
The potential effect of garlic extract and curcumin nanoparticles against complication accompanied with experimentally induced diabetes in rats
Fulltext Access 34 Pages 2018
Toward detection of toxoplasmosis from urine in mice using hydro-gel nanoparticles concentration and parallel reaction monitoring mass spectrometry
Fulltext Access 34 Pages 2018
Global gene expression analysis of macrophage response induced by nonporous and porous silica nanoparticles
Fulltext Access 34 Pages 2018
A potentially curative fetal intervention for hypoplastic left heart syndrome
Fulltext Access 34 Pages 2018
Tumor associated macrophages and angiogenesis dual-recognizable nanoparticles for enhanced cancer chemotherapy
Fulltext Access 34 Pages 2018
Crosstalk between endoplasmic reticulum stress and brain inflammation in Alzheimer's disease
Fulltext Access 34 Pages 2018
Food for thought: Leptin regulation of hippocampal function and its role in Alzheimer's disease
Fulltext Access 34 Pages 2018
Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease
Fulltext Access 34 Pages 2018
Mechanisms underlying anticonvulsant and proconvulsant actions of norepinephrine
Fulltext Access 34 Pages 2018
Prophylactic vaccination protects against the development of oxycodone self-administration
Fulltext Access 34 Pages 2018
Design and Evaluation of Bilayer Pump Tablet of Flurbiprofen Solid Dispersion for Zero-Order Controlled Delivery
Fulltext Access 34 Pages 2018
Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects
Fulltext Access 34 Pages 2018
Symmetrical and unsymmetrical substituted 2,5-diarylidene cyclohexanones as anti-parasitic compounds
Fulltext Access 34 Pages 2018
Cyclic Concatenated Genetic Encoder: A mathematical proposal for biological inferences
Fulltext Access 34 Pages 2018
Spectroscopic characterization of tablet properties in a continuous powder blending and tableting process
Fulltext Access 34 Pages 2018
Nanostructured lipid carriers versus solid lipid nanoparticles for the potential treatment of pulmonary hypertension via nebulization
Fulltext Access 34 Pages 2018
Exploiting polymer blending approach for fabrication of buccal chitosan-based composite sponges with augmented mucoadhesive characteristics
Fulltext Access 34 Pages 2018
Comparison among different “revealers” in the study of accelerated blood clearance phenomenon
Fulltext Access 34 Pages 2018
Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs
Fulltext Access 34 Pages 2018
Milk from transgenic goat expressing human lysozyme for recovery and treatment of gastrointestinal pathogens
Fulltext Access 34 Pages 2018
Gamma scintigraphic pulmonary deposition study of glycopyrronium/formoterol metered dose inhaler formulated using co-suspension delivery technology
Fulltext Access 34 Pages 2018
Enhanced efficacy and bioavailability of thymoquinone using nanoliposomal dosage form
Fulltext Access 34 Pages 2018
Curcumin loaded biomimetic composite graft for faster regeneration of skin in diabetic wounds
Fulltext Access 34 Pages 2018
Riluzole attenuates the efficacy of glutamatergic transmission by interfering with the size of the readily releasable neurotransmitter pool
Fulltext Access 34 Pages 2018
Comparative study in physico-chemical properties of gelatin derivatives and their microspheres as carriers for controlled release of green tea's extract
Fulltext Access 34 Pages 2018
Novel adhesive hyaluronic acid based solid dosage form for pediatric application
Fulltext Access 34 Pages 2018
Optimization and evaluation of mucoadhesive buccal films loaded with resveratrol
Fulltext Access 34 Pages 2018
A thermosensitive gel loaded with an enzyme and an antibiotic drug for the treatment of periprosthetic joint infection
Fulltext Access 34 Pages 2018
Phosphatidylserine Is Not Just a Cleanup Crew but Also a Well-Meaning Teacher
Fulltext Access 34 Pages 2018
Design, synthesis and molecular docking of thiazolidinedione based benzene sulphonamide derivatives containing pyrazole core as potential anti-diabetic agents
Fulltext Access 34 Pages 2018
New Polymorph Form of Dexamethasone Acetate
Fulltext Access 34 Pages 2018
Current trends in Hedgehog signaling pathway inhibition by small molecules
Fulltext Access 35 Pages 2018
Spray bandage strategy in topical drug delivery
Fulltext Access 35 Pages 2018
Rapid characterization of chemical markers for discrimination of Moutan Cortex and its processed products by direct injection-based mass spectrometry profiling and metabolomic method
Fulltext Access 35 Pages 2018
Albumin-Encapsulated Liposomes: A Novel Drug Delivery Carrier With Hydrophobic Drugs Encapsulated in the Inner Aqueous Core
Fulltext Access 35 Pages 2018
Superparamagnetic Iron Oxide-Loaded Lipid Nanocarriers Incorporated in Thermosensitive In Situ Gel for Magnetic Brain Targeting of Clonazepam
Fulltext Access 35 Pages 2018
Rapidly dissolving lacidipine nanoparticle strips for transbuccal administration
Fulltext Access 35 Pages 2018
Cancer chemotherapy: Effect of poloxamer modified nanoparticles on cellular function
Fulltext Access 35 Pages 2018
Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1,2,3-triazole conjugates
Fulltext Access 35 Pages 2018
Ocular irritation and cyclosporine A distribution in the eye tissues after administration of Solid Lipid Microparticles in the rabbit model
Fulltext Access 35 Pages 2018
Combined hyaluronate-based films loaded with pemetrexed and cisplatin for the treatment of malignant pleural mesothelioma: Preliminary evaluation in an orthotopic tumor recurrence model
Fulltext Access 35 Pages 2018
Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity
Fulltext Access 35 Pages 2018
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