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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

A computational study on the cisplatin drug interaction with boron nitride nanocluster
Fulltext Access 25 Pages 2018
New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action
Fulltext Access 25 Pages 2018
Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives
Fulltext Access 25 Pages 2018
Synthesis of proline derived benzenesulfonamides: A potent anti-Trypanosoma brucei gambiense agent
Fulltext Access 25 Pages 2018
Retinal pigment epithelial cells as a therapeutic tool and target against retinopathies
Fulltext Access 25 Pages 2018
Reconceptualizing delirium as a disorder of complex system failure
Fulltext Access 25 Pages 2018
Modeling of a Hybrid Langmuir Adsorption Isotherm for Describing Interactions Between Drug Molecules and Silica Surfaces
Fulltext Access 26 Pages 2018
Quality transitivity and traceability system of herbal medicine products based on quality markers
Fulltext Access 26 Pages 2018
Changes in brain oxygen and glucose induced by oxycodone: Relationships with brain temperature and peripheral vascular tone
Fulltext Access 26 Pages 2018
The effects of incretin hormones on cerebral glucose metabolism in health and disease
Fulltext Access 26 Pages 2018
Chronic stress dysregulates amygdalar output to the prefrontal cortex
Fulltext Access 26 Pages 2018
Formulation of levodopa containing dry powder for nasal delivery applying the quality-by-design approach
Fulltext Access 26 Pages 2018
Dexamethasone-diclofenac loaded polylactide nanoparticles: Preparation, release and anti-inflammatory activity
Fulltext Access 26 Pages 2018
Could reflex cough induced through nebulized capsaicin achieve airway clearance in patients with acute retention of lung secretions?
Fulltext Access 26 Pages 2018
Tablet fragmentation without a disintegrant: A novel design approach for accelerating disintegration and drug release from 3D printed cellulosic tablets
Fulltext Access 26 Pages 2018
Flow fine synthesis with heterogeneous catalysts
Fulltext Access 26 Pages 2018
Rose Bengal attached and dextran coated gadolinium oxide nanoparticles for potential diagnostic imaging applications
Fulltext Access 26 Pages 2018
Measurement of Average Aggregate Density by Sedimentation and Brownian Motion Analysis
Fulltext Access 26 Pages 2018
Push-Pull Controlled Drug Release Systems: Effect of Molecular Weight of Polyethylene Oxide on Drug Release
Fulltext Access 26 Pages 2018
Transport of ellipsoid fibers in oscillatory shear flows: Implications for aerosol deposition in deep airways
Fulltext Access 26 Pages 2018
Formulation and optimization of transfersome containing minoxidil and caffeine
Fulltext Access 26 Pages 2018
Preparation of absorbable surgical suture: Novel approach in biomedical application
Fulltext Access 26 Pages 2018
Design, optimization and pharmacodynamic comparison of dorzolamide hydrochloride soluble ocular drug insert prepared by using 32 factorial design
Fulltext Access 26 Pages 2018
Developmental role of adenosine kinase for the expression of sex-dependent neuropsychiatric behavior
Fulltext Access 26 Pages 2018
A new strategy for battling bacterial resistance: Turning potent, non-selective and potentially non-resistance-inducing biocides into selective ones
Fulltext Access 26 Pages 2018
Modulation of the mobility of a key region in human galactokinase: Impacts on catalysis and stability
Fulltext Access 26 Pages 2018
Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer
Fulltext Access 26 Pages 2018
Structure-activity relationship of novel (benzoylaminophenoxy)phenol derivatives as anti-prostate cancer agents
Fulltext Access 26 Pages 2018
Bioactive heterocycles containing a 3,4,5-trimethoxyphenyl fragment exerting potent antiproliferative activity through microtubule destabilization
Fulltext Access 26 Pages 2018
Phthalocyanine-sulfonamide conjugates: Synthesis and photodynamic inactivation of Gram-negative and Gram-positive bacteria
Fulltext Access 26 Pages 2018
The promoting effect of enteric materials on the oral absorption of larotaxel-loaded polymer-lipid hybrid nanoparticles
Fulltext Access 26 Pages 2018
Dual copper- and photoredox-catalysed reactions
Fulltext Access 26 Pages 2018
A hybrid of coumarin and phenylsulfonylfuroxan induces caspase-dependent apoptosis and cytoprotective autophagy in lung adenocarcinoma cells
Fulltext Access 26 Pages 2018
Rapid multiplexed detection of beta-amyloid and total-tau as biomarkers for Alzheimer's disease in cerebrospinal fluid
Fulltext Access 26 Pages 2018
Wisdom of crowds for synthetic accessibility evaluation
Fulltext Access 26 Pages 2018
Deep Convolutional Neural Network Analysis of Flow Imaging Microscopy Data to Classify Subvisible Particles in Protein Formulations
Fulltext Access 27 Pages 2018
Preparation and characterization of yeast-encapsulated doxorubicin microparticles
Fulltext Access 27 Pages 2018
Computational approach for generating robust models for discovering novel molecules as Cyclin Dependent Kinase 4 inhibitors
Fulltext Access 27 Pages 2018
Development of Coprocessed Chitin-Calcium Carbonate as Multifunctional Tablet Excipient for Direct Compression
Fulltext Access 27 Pages 2018
Preparation of defatted walnut meal hydrolysate-loaded enteric-coated pellets with enhanced oral absorption efficiency
Fulltext Access 27 Pages 2018
Design, synthesis, and biological evaluation of selective and potent Carbazole-based butyrylcholinesterase inhibitors
Fulltext Access 27 Pages 2018
Preparation and characterization of novel pseudo ceramide-based nanostructured lipid carriers for transdermal delivery of apigenin
Fulltext Access 27 Pages 2018
Pectin mediated synthesis of curcumin loaded poly(lactic acid) nanocapsules for cancer treatment
Fulltext Access 27 Pages 2018
Estimation of Drug Particle Size in Intact Tablets by 2-Dimensional X-Ray Diffractometry
Fulltext Access 27 Pages 2018
Effect of gelation and storage conditions on the oxidative stability of microemulsion and nanoemulsion delivery systems
Fulltext Access 27 Pages 2018
Methylphenidate significantly alters the functional coupling between the prefrontal cortex and dopamine neurons in the ventral tegmental area
Fulltext Access 27 Pages 2018
Bronchodilator effects of Lignosus rhinocerotis extract on rat isolated airways is linked to the blockage of calcium entry
Fulltext Access 27 Pages 2018
Design, syntheses and lipid accumulation inhibitory activities of novel resveratrol mimics
Fulltext Access 27 Pages 2018
Surface-enhanced Raman nanoparticles for tumor theranostics applications
Fulltext Access 27 Pages 2018
Oriental herbal medicine for generalized anxiety disorder: A systematic review of randomized controlled trials
Fulltext Access 27 Pages 2018
Design and development of a biorelevant simulated human lung fluid
Fulltext Access 27 Pages 2018
Recent advances in the synthesis, structural diversity, and applications of mesoionic 1,2,3-triazol-5-ylidene metal complexes
Fulltext Access 27 Pages 2018
Synthesis of 3-sulfonyl coumarins through radical sulfonylation with disulfides under catalyst-free conditions
Fulltext Access 27 Pages 2018
Resolution and evaluation of 3-chlorophenyl-3-hydroxypropionylhydroxamic acid as antivirulence agent with excellent eradication efficacy in Helicobacter pylori infected mice
Fulltext Access 27 Pages 2018
Initial Risk Assessment as part of the Quality by Design in peptide drug containing formulation development
Fulltext Access 27 Pages 2018
Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2
Fulltext Access 27 Pages 2018
Effects of dissolving microneedle fabrication parameters on the activity of encapsulated lysozyme
Fulltext Access 27 Pages 2018
In vitro studies of heparin-coated magnetic nanoparticles for use in the treatment of neointimal hyperplasia
Fulltext Access 27 Pages 2018
Folic acid-modified liposomal drug delivery strategy for tumor targeting of 5-fluorouracil
Fulltext Access 27 Pages 2018
Cell type-specific pharmacological kinase inhibition for cancer chemoprevention
Fulltext Access 27 Pages 2018
Sulfonamides containing curcumin scaffold: Synthesis, characterization, carbonic anhydrase inhibition and molecular docking studies
Fulltext Access 27 Pages 2018
Uptake and light-induced cytotoxicity of hyaluronic acid-grafted liposomes containing porphyrin in tumor cells
Fulltext Access 27 Pages 2018
Recent advances in the medical use of silver complex
Fulltext Access 27 Pages 2018
Novel thymol bearing oxypropanolamine derivatives as potent some metabolic enzyme inhibitors - Their antidiabetic, anticholinergic and antibacterial potentials
Fulltext Access 27 Pages 2018
Synthesis, biological activities, and molecular docking studies of 2-mercaptobenzimidazole based derivatives
Fulltext Access 28 Pages 2018
Grandiflorenic acid promotes death of promastigotes via apoptosis-like mechanism and affects amastigotes by increasing total iron bound capacity
Fulltext Access 28 Pages 2018
Protein corona and phospholipase activity drive selective accumulation of nanomicelles in atherosclerotic plaques
Fulltext Access 28 Pages 2018
Exploring lipid markers of the quality of coix seeds with different geographical origins using supercritical fluid chromatography mass spectrometry and chemometrics
Fulltext Access 28 Pages 2018
Ecoacoustic codes and ecological complexity
Fulltext Access 28 Pages 2018
Effects on oral fat load of a nutraceutical combination of fermented red rice, sterol esters and stanols, curcumin, and olive polyphenols: A randomized, placebo controlled trial
Fulltext Access 28 Pages 2018
A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age
Fulltext Access 28 Pages 2018
Metabolic changes after licorice consumption: A systematic review with meta-analysis and trial sequential analysis of clinical trials
Fulltext Access 28 Pages 2018
Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents
Fulltext Access 28 Pages 2018
Development of a dual extrusion printing technique for an acid- and thermo-labile drug
Fulltext Access 28 Pages 2018
Interrogating the microbiome: experimental and computational considerations in support of study reproducibility
Fulltext Access 28 Pages 2018
Natural oxyprenylated coumarins are modulators of melanogenesis
Fulltext Access 28 Pages 2018
Novel hydrazido benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies
Fulltext Access 28 Pages 2018
Effect of Controlled Ice Nucleation on Stability of Lactate Dehydrogenase During Freeze-Drying
Fulltext Access 28 Pages 2018
Curcumin-loaded Nanostructured Lipid Carriers for ocular drug delivery: Design optimization and characterization
Fulltext Access 28 Pages 2018
Synthesis, characterization and chlorhexidine release from either montmorillonite or palygorskite modified organoclays for antibacterial applications
Fulltext Access 28 Pages 2018
Development and in vitro evaluation of doxorubicin and celecoxib co-loaded bone targeted nanoparticles
Fulltext Access 28 Pages 2018
Dry powder coated osmotic drug delivery system
Fulltext Access 28 Pages 2018
Effect of Freeze Dryer Design on Heat Transfer Variability Investigated Using a 3D Mathematical Model
Fulltext Access 28 Pages 2018
Novel mixed vesicles containing lactobacilli biosurfactant for vaginal delivery of an anti-Candida agent
Fulltext Access 28 Pages 2018
A Newly Identified Impurity in Polysorbate 80, the Long-Chain Ketone 12-Tricosanone, Forms Visible Particles in a Biopharmaceutical Drug Product
Fulltext Access 28 Pages 2018
Process and scaling parameters for wet media milling in early phase drug development: A knowledge based approach
Fulltext Access 28 Pages 2018
Online effects of transcranial direct current stimulation on prefrontal metabolites in gambling disorder
Fulltext Access 28 Pages 2018
Lyophilized tablets for focal delivery of fluconazole and itraconazole through vaginal mucosa, rational design and in vitro evaluation
Fulltext Access 28 Pages 2018
An allometric approach of tumor-angiogenesis
Fulltext Access 28 Pages 2018
Objective assessment of the degree of improvement or deterioration with patients by means of Ipsative Trend Analysis of resting electroencephalograms
Fulltext Access 28 Pages 2018
Chronic sleep restriction increases pain sensitivity over time in a periaqueductal gray and nucleus accumbens dependent manner
Fulltext Access 28 Pages 2018
Poly(amidoamine) Dendrimers as a Pharmaceutical Excipient. Are We There yet?
Fulltext Access 29 Pages 2018
Understanding the Differences Between Cocrystal and Salt Aqueous Solubilities
Fulltext Access 29 Pages 2018
Ophthalmic Econazole Hydrogels for the Treatment of Fungal Keratitis
Fulltext Access 29 Pages 2018
Azulene-based compounds for targeting orexin receptors
Fulltext Access 29 Pages 2018
Copper as the most likely pathogenic divergence factor between lung fibrosis and emphysema
Fulltext Access 29 Pages 2018
Treatment of anorexia nervosa with palmitoylethanoamide
Fulltext Access 29 Pages 2018
Design, synthesis of novel vesicular systems using turpentine as a skin permeation enhancer
Fulltext Access 29 Pages 2018
Hypocretin/orexin deficiency decreases cocaine abuse liability
Fulltext Access 29 Pages 2018
Carbon nanomaterials in oncology: an expanding horizon
Fulltext Access 29 Pages 2018
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