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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Development and characterization of high payload combination dry powders of anti-tubercular drugs for treating pulmonary tuberculosis
Fulltext Access 39 Pages 2018
In vitro and in silico perspectives on biological and phytochemical profile of three halophyte species-A source of innovative phytopharmaceuticals from nature
Fulltext Access 39 Pages 2018
Stigmasterol upregulates immediate early genes and promotes neuronal cytoarchitecture in primary hippocampal neurons as revealed by transcriptome analysis
Fulltext Access 39 Pages 2018
Structural exploration of cinnamate-based phosphonic acids as inhibitors of bacterial ureases
Fulltext Access 39 Pages 2018
Potent anti-inflammatory effects of honokiol in human fetal membranes and myometrium
Fulltext Access 39 Pages 2018
Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities
Fulltext Access 39 Pages 2018
Exploring the tetrahydroisoquinoline thiohydantoin scaffold blockade the androgen receptor as potent anti-prostate cancer agents
Fulltext Access 39 Pages 2018
Voluntary running influences the efficacy of fluoxetine in a model of postpartum depression
Fulltext Access 39 Pages 2018
Rapid Bioavailability and Disposition protocol: A novel higher throughput approach to assess pharmacokinetics and steady-state brain distribution with reduced animal usage
Fulltext Access 39 Pages 2018
Insights into channel dysfunction from modelling and molecular dynamics simulations
Fulltext Access 39 Pages 2018
Molecular simulations for amorphous drug formulation: Polymeric matrix properties relevant to hot-melt extrusion
Fulltext Access 39 Pages 2018
Acupuncture for anxiety in dental patients: Systematic review and meta-analysis
Fulltext Access 39 Pages 2018
Leptin and ghrelin: Sewing metabolism onto neurodegeneration
Fulltext Access 39 Pages 2018
Modeling of ultra-small lipid nanoparticle surface charge for targeting glioblastoma
Fulltext Access 39 Pages 2018
Accessing lipophilicity of drugs with biomimetic models: A comparative study using liposomes and micelles
Fulltext Access 39 Pages 2018
Preparation and characterization of pyrimethamine solid dispersions and an evaluation of the physical nature of pyrimethamine in solid dispersions
Fulltext Access 39 Pages 2018
Solid dispersion of praziquantel enhanced solubility and improve the efficacy of the schistosomiasis treatment
Fulltext Access 39 Pages 2018
Naltrexone and nalmefene attenuate cocaine place preference in male mice
Fulltext Access 39 Pages 2018
Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes
Fulltext Access 39 Pages 2018
Evaluation of alcohol use disorders pharmacotherapies in a new preclinical model of binge drinking
Fulltext Access 39 Pages 2018
Monitoring the Phase Behavior of Supersaturated Solutions of Poorly Water-Soluble Drugs Using Fluorescence Techniques
Fulltext Access 39 Pages 2018
Gaining Thermodynamic Insight From Distinct Glass Formation Kinetics of Structurally Similar Organic Compounds
Fulltext Access 39 Pages 2018
Synthesis of structurally diverse biflavonoids
Fulltext Access 39 Pages 2018
Investigation into the pulmonary inflammopathology of exposure to nickel oxide nanoparticles in mice
Fulltext Access 39 Pages 2018
Challenges and opportunities in developing targeted molecular imaging to determine inner ear defects of sensorineural hearing loss
Fulltext Access 39 Pages 2018
Effects of acupuncture during in vitro fertilization or intracytoplasmic sperm injection: An updated systematic review and meta-analysis
Fulltext Access 39 Pages 2018
Gut microbiome correlates with altered striatal dopamine receptor expression in a model of compulsive alcohol seeking
Fulltext Access 39 Pages 2018
Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors
Fulltext Access 39 Pages 2018
Optimization of pellets manufacturing process using rough set theory
Fulltext Access 39 Pages 2018
Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays
Fulltext Access 39 Pages 2018
Multifunctional magnetic-responsive hydrogels to engineer tendon-to-bone interface
Fulltext Access 39 Pages 2018
Blood-brainbarrier disruption dictates nanoparticle accumulation following experimental brain injury
Fulltext Access 39 Pages 2018
Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity
Fulltext Access 39 Pages 2018
Melt-based screening method with improved predictability regarding polymer selection for amorphous solid dispersions
Fulltext Access 39 Pages 2018
Voriconazole and sertaconazole loaded colloidal nano-carriers for enhanced skin deposition and improved topical fungal treatment
Fulltext Access 40 Pages 2018
Sucrose or sucrose and caffeine differentially impact memory and anxiety-like behaviours, and alter hippocampal parvalbumin and doublecortin
Fulltext Access 40 Pages 2018
Identification of human, rat and mouse hydrolyzing enzymes bioconverting amino acid ester prodrug of ketoprofen
Fulltext Access 40 Pages 2018
Quercetin-loaded and unloaded electrospun membranes: Synthesis, characterization and in vitro release study
Fulltext Access 40 Pages 2018
Selenium nanomaterials in biomedicine-An overview of new opportunities in nanomedicine of selenium
Fulltext Access 40 Pages 2018
Cefazolin-loaded polycaprolactone fibers produced via different electrospinning methods: Characterization, drug release and antibacterial effect
Fulltext Access 40 Pages 2018
Effects of monoamines on the intrinsic excitability of lateral orbitofrontal cortex neurons in alcohol-dependent and non-dependent female mice
Fulltext Access 40 Pages 2018
Gold nanoparticles conjugating recombinant influenza hemagglutinin trimers and flagellin enhanced mucosal cellular immunity
Fulltext Access 40 Pages 2018
Predictive Modeling of Micellar Solubilization by Single and Mixed Nonionic Surfactants
Fulltext Access 40 Pages 2018
Quince seed hydrogel (glucuronoxylan): Evaluation of stimuli responsive sustained release oral drug delivery system and biomedical properties
Fulltext Access 40 Pages 2018
Development of Orally Applicable, Combinatorial Drug-Loaded Nanoparticles for the Treatment of Fibrosarcoma
Fulltext Access 40 Pages 2018
Development and characterization of gels and liposomes containing ovalbumin for nasal delivery
Fulltext Access 40 Pages 2018
Molecular dynamics investigation of the mechanical behavior of multi-layered graphyne and its family under tensile loading
Fulltext Access 40 Pages 2018
The therapeutic properties and applications of Aloe vera: A review
Fulltext Access 40 Pages 2018
Bottom-Up and Top-Down Approaches to Explore Sodium Dodecyl Sulfate and Soluplus on the Crystallization Inhibition and Dissolution of Felodipine Extrudates
Fulltext Access 40 Pages 2018
A novel biocompatible NiII tethered moiety as a glucose uptake agent and a hit against methicillin-resistant Staphylococcus aureus
Fulltext Access 40 Pages 2018
Effects of rigidity on the selectivity of protein kinase inhibitors
Fulltext Access 40 Pages 2018
Identification and development of benzoxazole derivatives as novel bacterial glutamate racemase inhibitors
Fulltext Access 40 Pages 2018
Direct pharmacological Akt activation rescues Alzheimer's disease like memory impairments and aberrant synaptic plasticity
Fulltext Access 40 Pages 2018
From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4
Fulltext Access 40 Pages 2018
Synthesis and biological evaluation of sulfur-containing shikonin oxime derivatives as potential antineoplastic agents
Fulltext Access 40 Pages 2018
Design, synthesis and anticancer activity of fluorocyclopentenyl-purines and - pyrimidines
Fulltext Access 40 Pages 2018
Engineering chemistry for the future of chemical synthesis
Fulltext Access 40 Pages 2018
Benzothiazole carbamates and amides as antiproliferative species
Fulltext Access 40 Pages 2018
Recent advances in small molecule based cancer immunotherapy
Fulltext Access 40 Pages 2018
Evaluating the clinical importance of bacterial degradation of therapeutic agents in the lower intestine of adults using adult fecal material
Fulltext Access 40 Pages 2018
Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes
Fulltext Access 40 Pages 2018
Deformable liposomes for skin therapy with human epidermal growth factor: The effect of liposomal surface charge
Fulltext Access 40 Pages 2018
Recent advances in aptamer-armed multimodal theranostic nanosystems for imaging and targeted therapy of cancer
Fulltext Access 40 Pages 2018
Neuroprotective effect of gold nanoparticles composites in Parkinson's disease model
Fulltext Access 40 Pages 2018
A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationships
Fulltext Access 41 Pages 2018
The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system: Role of neurogenesis and dendritic remodeling
Fulltext Access 41 Pages 2018
Intermittent streptozotocin administration induces behavioral and pathological features relevant to Alzheimer's disease and vascular dementia
Fulltext Access 41 Pages 2018
Adverse reactions of herbal medicine-A quantitative assessment of severity in Mauritius
Fulltext Access 41 Pages 2018
Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats
Fulltext Access 41 Pages 2018
Inhibiting pulmonary metastasis of breast cancer based on dual-targeting graphene oxide with high stability and drug loading capacity
Fulltext Access 41 Pages 2018
Chemo-biologic combinatorial drug delivery using folate receptor-targeted dendrimer nanoparticles for lung cancer treatment
Fulltext Access 41 Pages 2018
Design, synthesis, antibacterial evaluation and molecular docking studies of some new quinoxaline derivatives targeting dihyropteroate synthase enzyme
Fulltext Access 41 Pages 2018
Amino acids/peptides conjugated heterocycles: A tool for the recent development of novel therapeutic agents
Fulltext Access 41 Pages 2018
Identification of novel 2-benzyl-1-indanone analogs as interleukin-5 inhibitors
Fulltext Access 41 Pages 2018
A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery
Fulltext Access 41 Pages 2018
Design, synthesis, cytotoxicity and mechanism of novel dihydroartemisinin-coumarin hybrids as potential anti-cancer agents
Fulltext Access 41 Pages 2018
Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans
Fulltext Access 41 Pages 2018
Pyrimidine-chloroquinoline hybrids: Synthesis and antiplasmodial activity
Fulltext Access 41 Pages 2018
Colchicine prodrugs and codrugs: Chemistry and bioactivities
Fulltext Access 41 Pages 2018
Graphical contents list
Fulltext Access 41 Pages 2018
First population pharmacokinetic analysis showing increased quinolone metabolite formation and clearance in patients with cystic fibrosis compared to healthy volunteers
Fulltext Access 41 Pages 2018
Liposils: An effective strategy for stabilizing Paclitaxel loaded liposomes by surface coating with silica
Fulltext Access 41 Pages 2018
Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice
Fulltext Access 41 Pages 2018
Nasal dilation effects on olfactory deposition in unilateral and bi-directional deliveries: In vitro tests and numerical modeling
Fulltext Access 41 Pages 2018
Model and methods to assess hepatic function from indocyanine green fluorescence dynamical measurements of liver tissue
Fulltext Access 41 Pages 2018
Influence of formulation parameters on encapsulation and release characteristics of curcumin loaded in chitosan-based drug delivery carriers
Fulltext Access 41 Pages 2018
Water Activity and Its Significance in Topical Dosage Forms
Fulltext Access 41 Pages 2018
Butoconazole nitrate vaginal sponge: Drug release and antifungal efficacy
Fulltext Access 42 Pages 2018
Structure-based design of allosteric calpain-1 inhibitors populating a novel bioactivity space
Fulltext Access 42 Pages 2018
An integrated computational approach of molecular dynamics simulations, receptor binding studies and pharmacophore mapping analysis in search of potent inhibitors against tuberculosis
Fulltext Access 42 Pages 2018
Fluorescence-Based High-Throughput Salt Screening
Fulltext Access 42 Pages 2018
Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs
Fulltext Access 42 Pages 2018
Development and applications of a physiologically-based model of paediatric oral drug absorption
Fulltext Access 42 Pages 2018
Zero-order release of poorly water-soluble drug from polymeric films made via aqueous slurry casting
Fulltext Access 42 Pages 2018
Effects of hydrochlorothiazide and amlodipine on single oral dose pharmacokinetics of valsartan in healthy Korean subjects: Population model-based approach
Fulltext Access 42 Pages 2018
Modified equation for particle bonding area and strength with inclusion of powder fragmentation propensity
Fulltext Access 42 Pages 2018
Advances on photodynamic therapy of melanoma through novel ring-fused 5,15-diphenylchlorins
Fulltext Access 42 Pages 2018
Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation
Fulltext Access 42 Pages 2018
In silico design of small peptides antagonist against leptin receptor for the treatment of obesity and its associated immune-mediated diseases
Fulltext Access 42 Pages 2018
Separation of chloroform from a dilute solution using a cyclic peptide nanotube: A molecular dynamics study
Fulltext Access 42 Pages 2018
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