In-plane and out-of-plane rotational motion of individual chain molecules in steady shear flow of polymer melts and solutions Fulltext Access 49 Pages 2018
Is there a role for herbal medicine in the treatment and management of periodontal disease? Fulltext Access 49 Pages 2018
Tripterygium glycosides for treatment of nephrotic syndrome: A systematic review and meta-analysis of randomised controlled trials Fulltext Access 49 Pages 2018
Influenza A virus polymerase: an attractive target for next-generation anti-influenza therapeutics Fulltext Access 49 Pages 2018
Bioactive products from singlet oxygen photooxygenation of cannabinoids Fulltext Access 49 Pages 2018
Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead Fulltext Access 49 Pages 2018
Nanoencapsulation techniques for compounds and products with antioxidant and antimicrobial activity - A critical view Fulltext Access 49 Pages 2018
Activity-guided development of potent and selective toll-like receptor 9 antagonists Fulltext Access 50 Pages 2018
The medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse Fulltext Access 50 Pages 2018
Intermittent stimulation in the nucleus basalis of meynert improves sustained attention in rhesus monkeys Fulltext Access 50 Pages 2018
Morphological and functional evidence of increased excitatory signaling in the prelimbic cortex during ethanol withdrawal Fulltext Access 50 Pages 2018
Chitosan nanoparticles as a promising approach for pulmonary delivery of bedaquiline Fulltext Access 50 Pages 2018
Pyrrolopyrimidines: An update on recent advancements in their medicinal attributes Fulltext Access 50 Pages 2018
Formulation design of hydroxypropyl cellulose films for use as orally disintegrating dosage forms Fulltext Access 51 Pages 2018
Recent discovery of indoleamine-2,3-dioxygenase 1 inhibitors targeting cancer immunotherapy Fulltext Access 51 Pages 2018
Salt formation improved the properties of a candidate drug during early formulation development Fulltext Access 51 Pages 2018
Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications Fulltext Access 51 Pages 2018
Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity Fulltext Access 51 Pages 2018
Design of electrospun nanofibrous mats for osteogenic differentiation of mesenchymal stem cells Fulltext Access 51 Pages 2018
Activation of neural stem cells from quiescence drives reactive hippocampal neurogenesis after alcohol dependence Fulltext Access 51 Pages 2018
Sweeping of Adsorbed Therapeutic Protein on Prefillable Syringes Promotes Micron Aggregate Generation Fulltext Access 52 Pages 2018
Structure-based design of human immuno- and constitutive proteasomes inhibitors Fulltext Access 52 Pages 2018
Molecular dynamics simulation strategies for designing carbon-nanotube-based targeted drug delivery Fulltext Access 52 Pages 2018
Biological evaluation of indolizine-chalcone hybrids as new anticancer agents Fulltext Access 52 Pages 2018
Intranasal oxytocin administration promotes emotional contagion and reduces aggression in a mouse model of callousness Fulltext Access 52 Pages 2018
Elastic, dipole-dipole interaction and viscosity impact on vibrational properties of anisotropic hexagonal microtubule lattice Fulltext Access 53 Pages 2018
Structure-activity relationship study of hypoxia-activated prodrugs for proteoglycan-targeted chemotherapy in chondrosarcoma Fulltext Access 53 Pages 2018
Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity Fulltext Access 53 Pages 2018
Design, synthesis, biological evaluation and structure-activity relationship of sophoridine derivatives bearing pyrrole or indole scaffold as potential antitumor agents Fulltext Access 54 Pages 2018
Synthesis and antibacterial bioactivities of cationic deacetyl linezolid amphiphiles Fulltext Access 54 Pages 2018
Improved Human Pharmacokinetic Prediction of Hepatically Metabolized Drugs With Species-Specific Systemic Clearance Fulltext Access 54 Pages 2018
Biophysical Properties and Heating-Induced Aggregation of Lysine-Conjugated Antibody-Drug Conjugates Fulltext Access 54 Pages 2018
Anti-leishmanial click modifiable thiosemicarbazones: Design, synthesis, biological evaluation and in silico studies Fulltext Access 54 Pages 2018
Glucagon-like peptide-1 mediates effects of oral galactose in streptozotocin-induced rat model of sporadic Alzheimer's disease Fulltext Access 54 Pages 2018
Development and characterization of chitosan-based hydrogels as wound dressing materials Fulltext Access 54 Pages 2018
Amylin in Alzheimer's disease: Pathological peptide or potential treatment? Fulltext Access 54 Pages 2018
Organic arsenicals target thioredoxin reductase followed by oxidative stress and mitochondrial dysfunction resulting in apoptosis Fulltext Access 55 Pages 2018
Metabotropic glutamate receptor subtype 7 in the dorsal striatum oppositely modulates pain in sham and neuropathic rats Fulltext Access 55 Pages 2018
Effect of formulation and process variables on lipid based sustained release tablets via continuous twin screw granulation: A comparative study Fulltext Access 55 Pages 2018
Multi-kinetic release of benznidazole-loaded multiparticulate drug delivery systems based on polymethacrylate interpolyelectrolyte complexes Fulltext Access 55 Pages 2018
Chronic paroxetine treatment prevents disruption of methamphetamine-sensitive circadian oscillator in a transgenic mouse model of Huntington's disease Fulltext Access 55 Pages 2018
Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics Fulltext Access 56 Pages 2018
Design strategies for physical-stimuli-responsive programmable nanotherapeutics Fulltext Access 56 Pages 2018
Granulation development in batch-to-batch and continuous processes from a quality by design perspective Fulltext Access 57 Pages 2018
Novel chitosan-based solid-lipid nanoparticles to enhance the bio-residence of the miraculous phytochemical “Apocynin” Fulltext Access 57 Pages 2018
Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targets Fulltext Access 57 Pages 2018
Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression Fulltext Access 57 Pages 2018
Design and characterization of emulsified spray dried alginate microparticles as a carrier for the dually acting drug roflumilast Fulltext Access 58 Pages 2018
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis Fulltext Access 58 Pages 2018
Genetics update: Monogenetics, polygene disorders and the quest for modifying genes Fulltext Access 58 Pages 2018
Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile Fulltext Access 59 Pages 2018
Ketamine induces hippocampal apoptosis through a mechanism associated with the caspase-1 dependent pyroptosis Fulltext Access 59 Pages 2018
Drug discovery in tuberculosis. New drug targets and antimycobacterial agents Fulltext Access 59 Pages 2018
Synthesis and anticancer activity of novel water soluble benzimidazole carbamates Fulltext Access 59 Pages 2018
Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system Fulltext Access 60 Pages 2018
Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression Fulltext Access 60 Pages 2018
Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability Fulltext Access 60 Pages 2018
Nano-carrier enabled drug delivery systems for nose to brain targeting for the treatment of neurodegenerative disorders Fulltext Access 61 Pages 2018
Zwitterionic cocrystal of diclofenac and l-proline: Structure determination, solubility, kinetics of cocrystallization, and stability study Fulltext Access 61 Pages 2018
Novel multi-target compounds in the quest for new chemotherapies against Alzheimer's disease: An experimental and theoretical study Fulltext Access 61 Pages 2018
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells Fulltext Access 61 Pages 2018
Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores) Fulltext Access 62 Pages 2018
Systemic and local toxicity of metal debris released from hip prostheses: A review of experimental approaches Fulltext Access 62 Pages 2018
An Intercompany Perspective on Biopharmaceutical Drug Product Robustness Studies Fulltext Access 62 Pages 2018
Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for valproic acid and divalproex Fulltext Access 62 Pages 2018
Evolutionary epistemology: Reviewing and reviving with new data the research programme for distributed biological intelligence Fulltext Access 62 Pages 2018
Alkyl indole-based cannabinoid type 2 receptor tools: Exploration of linker and fluorophore attachment Fulltext Access 63 Pages 2018
Synthesis and structure-activity relationship studies of cruzain and rhodesain inhibitors Fulltext Access 64 Pages 2018
Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis Fulltext Access 65 Pages 2018
Structural-based design, synthesis, and antitumor activity of novel alloxazine analogues with potential selective kinase inhibition Fulltext Access 66 Pages 2018
Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms Fulltext Access 66 Pages 2018
Process Development and Robust Control of Physical Attributes of an Amorphous Drug Substance Fulltext Access 66 Pages 2018
Faster protein folding using enhanced conformational sampling of molecular dynamics simulation Fulltext Access 67 Pages 2018
Towards click chemistry: Multicomponent reactions via combinations of name reactions Fulltext Access 67 Pages 2018
Predicting Protein-Protein Interactions of Concentrated Antibody Solutions Using Dilute Solution Data and Coarse-Grained Molecular Models Fulltext Access 67 Pages 2018
The Application of Modeling and Prediction to the Formation and Stability of Amorphous Solid Dispersions Fulltext Access 67 Pages 2018
Fluorine walk: The impact of fluorine in quinolone amides on their activity against African sleeping sickness Fulltext Access 68 Pages 2018
Recent developments of quinolone-based derivatives and their activities against Escherichia coli Fulltext Access 68 Pages 2018
Design, synthesis and characterization of potent microtubule inhibitors with dual anti-proliferative and anti-angiogenic activities Fulltext Access 68 Pages 2018
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors Fulltext Access 69 Pages 2018
Detailed account on activation mechanisms of ruthenium coordination complexes and their role as antineoplastic agents Fulltext Access 69 Pages 2018