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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Success stories of natural product-based hybrid molecules for multi-factorial diseases
Fulltext Access 74 Pages 2018
Surface-modified mucoadhesive microgels as a controlled release system for miconazole nitrate to improve localized treatment of vulvovaginal candidiasis
Fulltext Access 76 Pages 2018
Structure-based design of bacterial transglycosylase inhibitors incorporating biphenyl, amine linker and 2-alkoxy-3-phosphorylpropanoate moieties
Fulltext Access 77 Pages 2018
Synthesis and biological evaluation of dihydroquinoline carboxamide derivatives as anti-tubercular agents
Fulltext Access 78 Pages 2018
Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease
Fulltext Access 79 Pages 2018
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease
Fulltext Access 81 Pages 2018
Surface functionalized dendrimers as controlled-release delivery nanosystems for tumor targeting
Fulltext Access 82 Pages 2018
Discovery of a potent glucokinase activator with a favorable liver and pancreas distribution pattern for the treatment of type 2 diabetes mellitus
Fulltext Access 82 Pages 2018
Experimental methods for flow and aerosol measurements in human airways and their replicas
Fulltext Access 83 Pages 2018
Polymorphism, Intermolecular Interactions, and Spectroscopic Properties in Crystal Structures of Sulfonamides
Fulltext Access 85 Pages 2018
Current progress on antioxidants incorporating the pyrazole core
Fulltext Access 85 Pages 2018
Recent advance in oxazole-based medicinal chemistry
Fulltext Access 90 Pages 2018
An update on small molecule strategies targeting leishmaniasis
Fulltext Access 93 Pages 2018
Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives
Fulltext Access 94 Pages 2018
Cascade reactions as efficient and universal tools for construction and modification of 6-, 5-, 4- and 3-membered sulfur heterocycles of biological relevance
Fulltext Access 97 Pages 2018
Traditional plant based medicines used to treat musculoskeletal disorders in Northern Pakistan
Fulltext Access 97 Pages 2018
Syntheses and anti-pancreatic cancer activities of rakicidin A analogues
Fulltext Access 101 Pages 2018
An overview of quinazolines: Pharmacological significance and recent developments
Fulltext Access 103 Pages 2018
Lipid based nanocarriers: a translational perspective
Fulltext Access 107 Pages 2018
Pyrrole: An insight into recent pharmacological advances with structure activity relationship
Fulltext Access 110 Pages 2018
Recent advancement of piperidine moiety in treatment of cancer- A review
Fulltext Access 133 Pages 2018
Current anti-diabetic agents and their molecular targets: A review
Fulltext Access 136 Pages 2018
Towards the targeted management of aggressive periodontitis
Fulltext Access 4 Pages 2017
Rhinitis and sleep disorders: The trigeminocardiac reflex link?
Fulltext Access 4 Pages 2017
Polycystic ovary syndrome in men
Fulltext Access 4 Pages 2017
A hypothesis for mechanism for brain oedema due to glycine
Fulltext Access 4 Pages 2017
Iron chelation for the treatment of uveitis
Fulltext Access 4 Pages 2017
Chronic fatigue syndrome and idiopathic intracranial hypertension: Different manifestations of the same disorder of intracranial pressure?
Fulltext Access 4 Pages 2017
In pursuit of cancer metastasis therapy by bacteria and its biofilms: History or future
Fulltext Access 4 Pages 2017
Impaired illness awareness and leftward visuospatial inattention in schizophrenia are attributable to a common neural deficit - Posterior parietal hemispheric imbalance
Fulltext Access 4 Pages 2017
Hepcidin and metallothioneins as molecular base for sex-dependent differences in clinical course of experimental autoimmune encephalomyelitis in chronic iron overload
Fulltext Access 4 Pages 2017
Implications of bisphosphonate calcium ion depletion interfering with desmosome epithelial seal in osseointegrated implants and pressure ulcers
Fulltext Access 4 Pages 2017
The neural signature of emotional memories in serial crimes
Fulltext Access 4 Pages 2017
Infrared thermal measurement method to evaluate the skin cooling effect of topical products and the impact of microstructure of creams
Fulltext Access 4 Pages 2017
Male contraception: Prospects for sound and ultrasound
Fulltext Access 4 Pages 2017
Horseradish and radish peroxidases eaten with fish could help explain observed associations between fish consumption and protection from age-related dementia
Fulltext Access 4 Pages 2017
A novel genetic model to explore the Brenner hypothesis: Linking nephron endowment and number with hypertension
Fulltext Access 4 Pages 2017
The potential management of oral candidiasis using anti-biofilm therapies
Fulltext Access 4 Pages 2017
Is periodontitis a risk factor for infections in cirrhotic patients?
Fulltext Access 4 Pages 2017
On human parthenogenesis
Fulltext Access 4 Pages 2017
Tidal chemotherapy in premenopausal patients with hormone receptor positive breast cancer
Fulltext Access 4 Pages 2017
Nanoparticles as agents targeting cholesterol crystallization in atherosclerosis
Fulltext Access 4 Pages 2017
Mild anemia during pregnancy upregulates placental vascularity development
Fulltext Access 4 Pages 2017
Pathophysiological explanation of cardiovascular benefits of sodium-glucose cotransporter-2 inhibitors by neurotrophic theory
Fulltext Access 4 Pages 2017
Interleukin-1beta may act on hepatocytes to boost plasma homocysteine - The increased cardiovascular risk associated with elevated homocysteine may be mediated by this cytokine
Fulltext Access 4 Pages 2017
A novel inhibitor of endocannabinoid catabolic enzymes sheds light on behind the scene interplay between chronic pain, analgesic tolerance, and heroin dependence
Fulltext Access 4 Pages 2017
Identification of pyruvate dehydrogenase kinase 1 inhibitors with anti-osteosarcoma activity
Fulltext Access 4 Pages 2017
Asymmetric conjugate addition of 5-benzylfurfurals to nitroalkenes using a diaminomethylenemalononitrile organocatalyst
Fulltext Access 4 Pages 2017
Oxoammonium salt-mediated oxidative nitriles synthesis from aldehydes with ammonium acetate
Fulltext Access 4 Pages 2017
Service animal as adjuvant treatment for restless leg syndrome
Fulltext Access 4 Pages 2017
Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic
Fulltext Access 4 Pages 2017
Controlled hydrogenation of diphenylacetylene using alkylammonium formate
Fulltext Access 4 Pages 2017
Synthesis of cananodine by intramolecular epoxide opening
Fulltext Access 4 Pages 2017
Silylated iminophosphonates: Novel reactive synthons for the preparation of fluorinated aminophosphonates and aminophosphonic acids
Fulltext Access 4 Pages 2017
Acid/base controllable self-complexes that mimic flapping butterfly
Fulltext Access 4 Pages 2017
Iodine-mediated rearrangements of diallylsilanes
Fulltext Access 4 Pages 2017
Protonation-induced switching of pleated foldamers of diaminonaphthalene-bipyridinium polymers
Fulltext Access 4 Pages 2017
Literature
Fulltext Access 4 Pages 2017
Pyridone photoelectrocyclizations to pyridophenanthrenes
Fulltext Access 4 Pages 2017
On the probable composition of 'Jamaican stone' aphrodisiac
Fulltext Access 4 Pages 2017
New aromatic compounds from the rhizomes of Homalomena occulta
Fulltext Access 4 Pages 2017
New lignan glycosides from the root barks of Litsea glutinosa
Fulltext Access 4 Pages 2017
Design, synthesis, and cytotoxicity of stabilized mycolactone analogs
Fulltext Access 4 Pages 2017
Solvent free synthesis of ynones using magnetically recoverable Copper-ferrite nanoparticles
Fulltext Access 4 Pages 2017
In vitro studies on the inhibition of colon cancer by amino acid derivatives of bromothiazole
Fulltext Access 4 Pages 2017
Fluorescence detection of serum albumin with a turnover-based sensor utilizing Kemp elimination reaction
Fulltext Access 4 Pages 2017
Synthesis of 3- and 29-substituted celastrol derivatives and structure-activity relationship studies of their cytotoxic activities
Fulltext Access 4 Pages 2017
Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides
Fulltext Access 4 Pages 2017
Design and multi-step synthesis of chalcone-polyamine conjugates as potent antiproliferative agents
Fulltext Access 4 Pages 2017
Evaluation of tetraether lipid-based liposomal carriers for encapsulation and retention of nucleoside-based drugs
Fulltext Access 4 Pages 2017
Synthesis and antiviral evaluation of novel 1,3,4-oxadiazole/thiadiazole-chalcone conjugates
Fulltext Access 4 Pages 2017
Synthesis and biological evaluation of pyridinium-functionalized carbazole derivatives as promising antibacterial agents
Fulltext Access 4 Pages 2017
Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands
Fulltext Access 4 Pages 2017
Synthesis of pyrrole-imidazole polyamide oligomers based on a copper-catalyzed cross-coupling strategy
Fulltext Access 4 Pages 2017
Synthesis of camphecene derivatives using click chemistry methodology and study of their antiviral activity
Fulltext Access 4 Pages 2017
Synthesis and characterization of new hexahelicene derivatives
Fulltext Access 4 Pages 2017
The reaction of cinnamaldehyde and cinnam(o)yl derivatives with thiols
Fulltext Access 4 Pages 2017
The chair-boat energy difference in 1,3-dioxane
Fulltext Access 4 Pages 2017
Photoinduced oxygenation of dehydrorotenones
Fulltext Access 4 Pages 2017
Gibbane metabolites from ent-kaura-2,16-dien-19-ol
Fulltext Access 4 Pages 2017
An analysis of the diastereomeric transition state interactions for stereoselective epoxidation of acyclic allylic alcohols with peroxy-acids
Fulltext Access 4 Pages 2017
A simple synthesis of choline alkyl phosphates
Fulltext Access 4 Pages 2017
Synthesis of diaryl ethers from tyrosine derivatives
Fulltext Access 4 Pages 2017
A novel esterification procedure applied to synthesis of biologically active esters of Foscarnet
Fulltext Access 4 Pages 2017
1-(Phenylseleno)-2-(p-toluenesulfonyl)ethyne. A novel acetylenic sulfone that undergoes normal and anti-Michael nucleophilic additions
Fulltext Access 4 Pages 2017
Convenient synthesis of new amphiphilic triphenylphosphine analogues for aqueous biphasic catalysis
Fulltext Access 4 Pages 2017
Instructions to contributors
Fulltext Access 4 Pages 2017
Temperature induced rotation in a [4.4]cyclophane
Fulltext Access 4 Pages 2017
Graphical contents list
Fulltext Access 4 Pages 2017
Convenient synthesis of selected meta- and ortho-substituted pentaarylpyridines via the Suzuki-Miyaura cross-coupling reaction
Fulltext Access 4 Pages 2017
A four-step tandem synthesis of 3,5-diaroyl-4-arylpyrazoles from 1,3-diaryl-propane-1,3-diketones
Fulltext Access 4 Pages 2017
A mild halogenation of pyrazoles using sodium halide salts and Oxone
Fulltext Access 4 Pages 2017
Preparative-scale synthesis of amino coumarins through new sequential nitration and reduction protocol
Fulltext Access 4 Pages 2017
Ethyl acetate as an acetyl surrogate for the iodine catalyzed acetylation of alcohols
Fulltext Access 4 Pages 2017
Synthesis of thiazolidin-4-ones via [3+2] cycloaddition of in situ generated aza-oxyallylic cations with isothiocyanates
Fulltext Access 4 Pages 2017
Copper catalyzed synthesis of benzoxazoles and benzothiazoles via tandem manner
Fulltext Access 4 Pages 2017
Cobalt-catalyzed isocyanide insertion cyclization to dihydrobenzoimidazotriazins
Fulltext Access 4 Pages 2017
Reaction of 2-propargylphenylcarbamates with diphenyliodonium salts via Meyer-Schuster rearrangement
Fulltext Access 4 Pages 2017
Chemoselective synthesis of novel spiropyrano acenaphthylene derivatives via one-pot four-component reaction
Fulltext Access 4 Pages 2017
Efficient synthesis of pyrazine boronic esters via palladium-catalyzed Miyaura borylation
Fulltext Access 4 Pages 2017
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