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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Exploring the potential of boron-doped nanographene as efficient charge transport and nonlinear optical material: A first-principles study
Fulltext Access 35 Pages 2017
Broad spectrum targeting of tumor vasculature by medicinal plants: An updated review
Fulltext Access 35 Pages 2017
Multifunctional iminochromene-2H-carboxamide derivatives containing different aminomethylene triazole with BACE1 inhibitory, neuroprotective and metal chelating properties targeting Alzheimer's disease
Fulltext Access 35 Pages 2017
Structural insights of cyclin dependent kinases: Implications in design of selective inhibitors
Fulltext Access 35 Pages 2017
Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives
Fulltext Access 35 Pages 2017
In silico design of knowledge-based Plasmodium falciparum epitope ensemble vaccines
Fulltext Access 35 Pages 2017
Synthesis and molecular modelling studies of phenyl linked oxadiazole-phenylhydrazone hybrids as potent antileishmanial agents
Fulltext Access 35 Pages 2017
Synthesis and antibacterial activities of novel pleuromutilin derivatives with a substituted pyrimidine moiety
Fulltext Access 35 Pages 2017
Design, synthesis and evaluation of 4-aminoquinoline-purine hybrids as potential antiplasmodial agents
Fulltext Access 35 Pages 2017
Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action
Fulltext Access 35 Pages 2017
Design, synthesis and cytotoxic activity of certain novel chalcone analogous compounds
Fulltext Access 35 Pages 2017
Topological pattern for the search of new active drugs against methicillin resistant Staphylococcus aureus
Fulltext Access 35 Pages 2017
Synthesis, antimicrobial, antiquorum-sensing and antitumor activities of new benzimidazole analogs
Fulltext Access 35 Pages 2017
Design, synthesis, kinetic mechanism and molecular docking studies of novel 1-pentanoyl-3-arylthioureas as inhibitors of mushroom tyrosinase and free radical scavengers
Fulltext Access 35 Pages 2017
Theoretical investigation on second-order nonlinear optical properties of ruthenium alkynyl-dihydroazulene/vinylheptafulvene complexes
Fulltext Access 35 Pages 2017
Study of the mechanism of protonated histidine-induced conformational changes in the Zika virus dimeric envelope protein using accelerated molecular dynamic simulations
Fulltext Access 35 Pages 2017
Specific interactions between androgen receptor and its ligand: ab initio molecular orbital calculations in water
Fulltext Access 35 Pages 2017
Investigating therapeutic usage of combined Ticagrelor and Aspirin through solid-state and analytical studies
Fulltext Access 36 Pages 2017
Novel technologies for the delivery of ocular therapeutics in glaucoma
Fulltext Access 36 Pages 2017
Covalent binding design strategy: A prospective method for discovery of potent targeted anticancer agents
Fulltext Access 36 Pages 2017
Nanomolar anti-sickling compounds identified by ligand-based pharmacophore approach
Fulltext Access 36 Pages 2017
Urea-containing peptide boronic acids as potent proteasome inhibitors
Fulltext Access 36 Pages 2017
Design, synthesis, biological evaluation, and molecular modeling studies of chalcone-rivastigmine hybrids as cholinesterase inhibitors
Fulltext Access 36 Pages 2017
Freeze dried solid dispersion of exemestane: A way to negate an aqueous solubility and oral bioavailability problems
Fulltext Access 36 Pages 2017
Analysis of Nonlinear Pharmacokinetics of a Highly Albumin-Bound Compound: Contribution of Albumin-Mediated Hepatic Uptake Mechanism
Fulltext Access 36 Pages 2017
Retina-to-Blood Transport of 1-Methyl-4-Phenylpyridinium Involves Carrier-Mediated Process at the Blood-Retinal Barrier
Fulltext Access 36 Pages 2017
Computer design, synthesis, and bioactivity analyses of drugs like fingolimod used in the treatment of multiple sclerosis
Fulltext Access 36 Pages 2017
Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker
Fulltext Access 36 Pages 2017
Pulmonary Administration of Soluble Antigen Arrays Is Superior to Antigen in Treatment of Experimental Autoimmune Encephalomyelitis
Fulltext Access 36 Pages 2017
Drug Delivery Innovations to Address Global Health Challenges for Pediatric and Geriatric Populations (Through Improvements in Patient Compliance)
Fulltext Access 36 Pages 2017
Optical probes and sensors as perspective tools in epigenetics
Fulltext Access 36 Pages 2017
Evaluation of Heat Flux Measurement as a New Process Analytical Technology Monitoring Tool in Freeze Drying
Fulltext Access 36 Pages 2017
Risk management and statistical multivariate analysis approach for design and optimization of satranidazole nanoparticles
Fulltext Access 36 Pages 2017
Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice
Fulltext Access 36 Pages 2017
Magnetic, but not non-magnetic, reduced graphene oxide in spinal cord increases nociceptive neuronal responsiveness
Fulltext Access 36 Pages 2017
Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic-ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia
Fulltext Access 36 Pages 2017
Statistical Considerations Concerning Dissimilar Regulatory Requirements for Dissolution Similarity Assessment. The Example of Immediate-Release Dosage Forms
Fulltext Access 36 Pages 2017
Chitin's Functionality as a Novel Disintegrant: Benchmarking Against Commonly Used Disintegrants in Different Physicochemical Environments
Fulltext Access 36 Pages 2017
Magnetically-induced elimination of Staphylococcus aureus by magnetotactic bacteria under a swing magnetic field
Fulltext Access 36 Pages 2017
Insight Into a Novel Strategy for the Design of Tablet Formulations Intended for Direct Compression
Fulltext Access 36 Pages 2017
Large porous particles for respiratory drug delivery. Glycine-based formulations
Fulltext Access 36 Pages 2017
Molecular dynamics of conformation-specific dopamine transporter-inhibitor complexes
Fulltext Access 36 Pages 2017
Nanotechnology-based delivery systems to release growth factors and other endogenous molecules for chronic wound healing
Fulltext Access 36 Pages 2017
A general method for determining molecular interfaces and layers
Fulltext Access 36 Pages 2017
Enhancing the efficiency of thiomers: Utilizing a highly mucoadhesive polymer as backbone for thiolation and preactivation
Fulltext Access 37 Pages 2017
Poly (amidoamine) dendrimer-mediated hybrid formulation for combination therapy of ramipril and hydrochlorothiazide
Fulltext Access 37 Pages 2017
Memantine-derived drugs as potential antitumor agents for the treatment of glioblastoma
Fulltext Access 37 Pages 2017
Molecular dynamics study of micelles properties according to their size
Fulltext Access 37 Pages 2017
Dissolving Microneedles Integrated With Liquid Crystals Facilitate Transdermal Delivery of Sinomenine Hydrochloride
Fulltext Access 37 Pages 2017
Synthesis and characterization of genistein conjugated with gold nanoparticles and the study of their cytotoxic properties
Fulltext Access 37 Pages 2017
Liposphere mediated topical delivery of thymoquinone in the treatment of psoriasis
Fulltext Access 37 Pages 2017
Identification of novel serotonin reuptake inhibitors targeting central and allosteric binding sites: A virtual screening and molecular dynamics simulations study
Fulltext Access 37 Pages 2017
Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property
Fulltext Access 37 Pages 2017
Dependence of Punch Sticking on Compaction Pressure-Roles of Particle Deformability and Tablet Tensile Strength
Fulltext Access 37 Pages 2017
Computational Modeling of Polymeric Physicochemical Properties for Formulation Development of a Drug Containing Basic Functionality
Fulltext Access 37 Pages 2017
Morphine dosing strategy plays a key role in the generation and duration of the produced antinociceptive tolerance
Fulltext Access 37 Pages 2017
Improved oral absorption profile of itraconazole in hypochlorhydria by self-micellizing solid dispersion approach
Fulltext Access 37 Pages 2017
Optimization of paeonol-loaded poly(butyl-2-cyanoacrylate) nanocapsules by central composite design with response surface methodology together with the antibacterial properties
Fulltext Access 37 Pages 2017
Recent advances of pyrazole-containing derivatives as anti-tubercular agents
Fulltext Access 37 Pages 2017
Ethnomedicinal survey of medicinal plants of Chinglai valley, Buner district, Pakistan
Fulltext Access 37 Pages 2017
Some Lessons Learned From a Comparison Between Sedimentation Velocity Analytical Ultracentrifugation and Size Exclusion Chromatography to Characterize and Quantify Protein Aggregates
Fulltext Access 37 Pages 2017
4-Phenyl quinoline derivatives as potential serotonin receptor ligands with antiproliferative activity
Fulltext Access 37 Pages 2017
Synthesis and antiproliferative activity of monocationic arylthiophene derivatives
Fulltext Access 37 Pages 2017
Synthesis, alkaline phosphatase inhibition studies and molecular docking of novel derivatives of 4-quinolones
Fulltext Access 37 Pages 2017
Opening eyes to nanomedicine: Where we are, challenges and expectations on nanotherapy for diabetic retinopathy
Fulltext Access 37 Pages 2017
Design, synthesis and biological evaluation of new pyrrolidine carboxamide analogues as potential chemotherapeutic agents for hepatocellular carcinoma
Fulltext Access 37 Pages 2017
Puromycin based inhibitors of aminopeptidases for the potential treatment of hematologic malignancies
Fulltext Access 37 Pages 2017
Biological characteristics, bioactive components and antineoplastic properties of sporoderm-broken spores from wild Cordyceps cicadae
Fulltext Access 38 Pages 2017
Perspectives on Subcutaneous Route of Administration as an Immunogenicity Risk Factor for Therapeutic Proteins
Fulltext Access 38 Pages 2017
Dissolution Failure of Solid Oral Drug Products in Field Alert Reports
Fulltext Access 38 Pages 2017
Synthesis of new spirooxindole-pyrrolothiazole derivatives: Anti-cancer activity and molecular docking
Fulltext Access 38 Pages 2017
Identification of Endogenous Biomarkers to Predict the Propensity of Drug Candidates to Cause Hepatic or Renal Transporter-Mediated Drug-Drug Interactions
Fulltext Access 38 Pages 2017
Prediction of Air Entrapment in Tableting: An Approximate Solution
Fulltext Access 38 Pages 2017
Biocompatibility assessment of silk nanoparticles: hemocompatibility and internalization by human blood cells
Fulltext Access 38 Pages 2017
An efficient size-dependent shear deformable shell model and molecular dynamics simulation for axial instability analysis of silicon nanoshells
Fulltext Access 38 Pages 2017
Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease
Fulltext Access 38 Pages 2017
Innovative approach for identifying root causes of glass defects in sterile drug product manufacturing
Fulltext Access 38 Pages 2017
Novel unsaturated glycyrrhetic acids derivatives: Design, synthesis and anti-inflammatory activity
Fulltext Access 38 Pages 2017
Assessment of the chromatographic lipophilicity of eight cephalosporins on different stationary phases
Fulltext Access 38 Pages 2017
Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments
Fulltext Access 38 Pages 2017
Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides
Fulltext Access 38 Pages 2017
Ketamine modulates hippocampal neurogenesis and pro-inflammatory cytokines but not stressor induced neurochemical changes
Fulltext Access 38 Pages 2017
Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action
Fulltext Access 38 Pages 2017
New derivatives of quinoline-4-carboxylic acid with antiplasmodial activity
Fulltext Access 38 Pages 2017
Synthesis, evaluation and molecular modelling studies of 2-(carbazol-3-yl)-2-oxoacetamide analogues as a new class of potential pancreatic lipase inhibitors
Fulltext Access 38 Pages 2017
Synthesis and investigation of novel 6-(1,2,3-triazol-4-yl)-4-aminoquinazolin derivatives possessing hydroxamic acid moiety for cancer therapy
Fulltext Access 38 Pages 2017
Specific interactions between zinc metalloproteinase and its inhibitors: Ab initio fragment molecular orbital calculations
Fulltext Access 38 Pages 2017
Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: A combined computational and experimental study
Fulltext Access 38 Pages 2017
A preformulation evaluation of a photosensitive surface active compound, explaining concentration dependent degradation
Fulltext Access 38 Pages 2017
Smuggling gold nanoparticles across cell types - A new role for exosomes in gene silencing
Fulltext Access 39 Pages 2017
Elucidation of the Intestinal Absorption of para-Aminobenzoic Acid, a Marker for Dietary Intake
Fulltext Access 39 Pages 2017
Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1
Fulltext Access 39 Pages 2017
In silico target prediction for elucidating the mode of action of herbicides including prospective validation
Fulltext Access 39 Pages 2017
Organic Anion-Transporting Polypeptide and Efflux Transporter-Mediated Hepatic Uptake and Biliary Excretion of Cilostazol and Its Metabolites in Rats and Humans
Fulltext Access 39 Pages 2017
Application of Quantitative Targeted Absolute Proteomics to Profile Protein Expression Changes of Hepatic Transporters and Metabolizing Enzymes During Cholic Acid-Promoted Liver Regeneration
Fulltext Access 39 Pages 2017
Systematic development of a gastroretentive fixed dose combination of lamivudine and zidovudine for increased patient compliance
Fulltext Access 39 Pages 2017
Cannabinoid 2 receptor is a novel anti-inflammatory target in experimental proliferative vitreoretinopathy
Fulltext Access 39 Pages 2017
Mouse models of nonalcoholic steatohepatitis in preclinical drug development
Fulltext Access 39 Pages 2017
Aerosolizable modified-release particles of montelukast improve retention and availability of the drug in the lungs
Fulltext Access 39 Pages 2017
Formulation of polysaccharide-based nanoparticles for local administration into the oral cavity
Fulltext Access 39 Pages 2017
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