Diversity oriented synthesis and IKK inhibition of aminobenzimidazole tethered quinazoline-2,4-diones, thioxoquinazolin-4-ones, benzodiazepine-2,3,5-triones, isoxazoles and isoxazolines Fulltext Access 5 Pages 2015
Metronidazole hydrazone conjugates: Design, synthesis, antiamoebic and molecular docking studies Fulltext Access 5 Pages 2015
Novel 5-functionalized-pyrazoles: Synthesis, characterization and pharmacological screening Fulltext Access 5 Pages 2015
Discovery of non-competitive thrombin inhibitor derived from competitive tryptase inhibitor skeleton: Shift in molecular recognition resulted from skeletal conversion of carboxylate into phosphonate Fulltext Access 5 Pages 2015
Synthesis and evaluation of novel fluorinated pyrazolo-1,2,3-triazole hybrids as antimycobacterial agents Fulltext Access 5 Pages 2015
Synthesis, molecular docking and anticancer studies of peptides and iso-peptides Fulltext Access 5 Pages 2015
Biaryls as potent, tunable dual neurokinin 1 receptor antagonists and serotonin transporter inhibitors Fulltext Access 5 Pages 2015
The synthesis and evaluation of sesamol and benzodioxane derivatives as inhibitors of monoamine oxidase Fulltext Access 5 Pages 2015
trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: Prime site exploration using an oxygen linker Fulltext Access 5 Pages 2015
Synthesis of novel pleuromutilin derivatives. Part 1: Preliminary studies of antituberculosis activity Fulltext Access 5 Pages 2015
Development of constrained tamoxifen mimics and their antiproliferative properties against breast cancer cells Fulltext Access 5 Pages 2015
Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity Fulltext Access 5 Pages 2015
Synthesis, antimycobacterial and antifungal evaluation of some new 1-ethyl-5-(hetero)aryl-6-styryl-1,6-dihydropyrazine-2,3-dicarbonitriles Fulltext Access 5 Pages 2015
Synthesis and anti-biofilm activities of dihydro-pyrrol-2-one derivatives on Pseudomonas aeruginosa Fulltext Access 5 Pages 2015
Recognition of a monoclonal antibody against a small molecular weight antigen by monitoring the antigen–antibody reaction using fluorescence labeled structured peptides Fulltext Access 5 Pages 2015
Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening Fulltext Access 5 Pages 2015
Targeted fluorescent probes for detection of oxidative stress in the mitochondria Fulltext Access 5 Pages 2015
Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone–6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease Fulltext Access 5 Pages 2015
Monitoring of drug release kinetics from thin polymer films by multi-parametric surface plasmon resonance Fulltext Access 6 Pages 2015
Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection Fulltext Access 6 Pages 2015
Measurement of shrinkage and cracking in lyophilized amorphous cakes. Part IV: Effects of freezing protocol Fulltext Access 6 Pages 2015
In vivo pharmacological evaluation of a lactose-conjugated luteinizing hormone releasing hormone analogue Fulltext Access 6 Pages 2015
Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability Fulltext Access 6 Pages 2015
Mono-lithocholated exendin-4-loaded glycol chitosan nanoparticles with prolonged antidiabetic effects Fulltext Access 6 Pages 2015
Drug-in-cyclodextrin-in-liposomes: A novel drug delivery system for flurbiprofen Fulltext Access 6 Pages 2015
Investigation on the aerosol performance of dry powder inhalation hypromellose capsules with different lubricant levels Fulltext Access 6 Pages 2015
Crystal face identification by Raman microscopy for assessment of crystal habit of a drug Fulltext Access 6 Pages 2015
Assessment of the effects of sterilization methods on protein drug stability by elucidating decomposition mechanism and material analysis Fulltext Access 6 Pages 2015
Pharmaceutical nanotechnologyA comprehensive production method of self-cryoprotected nano-liposome powders Fulltext Access 6 Pages 2015
Gastrointestinal release behaviour of modified-release drug products: Dynamic dissolution testing of mesalazine formulations Fulltext Access 6 Pages 2015
Vancomycin-modified silica: Synthesis, controlled release and biological activity of the drug Fulltext Access 6 Pages 2015
Gene expression profiling in the lungs of phenylhydrazine-treated rats: The contribution of pro-inflammatory response and endothelial dysfunction to acute thrombosis Fulltext Access 6 Pages 2015
Simultaneous determination of phentermine and topiramate in human plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study Fulltext Access 6 Pages 2015
Seven-membered ring scaffolds for drug discovery: Access to functionalised azepanes and oxepanes through diazocarbonyl chemistry Fulltext Access 6 Pages 2015
2- and 3-Fluoro-3-deazaneplanocins, 2-fluoro-3-deazaaristeromycins, and 3-methyl-3-deazaneplanocin: Synthesis and antiviral properties Fulltext Access 6 Pages 2015
A peptide affinity reagent for isolating an intact and catalytically active multi-protein complex from mammalian cells Fulltext Access 6 Pages 2015
Towards the computational design of protein post-translational regulation Fulltext Access 6 Pages 2015
Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1 Fulltext Access 6 Pages 2015
Efficient method for iodine radioisotope labeling of cyclooctyne-containing molecules using strain-promoted copper-free click reaction Fulltext Access 6 Pages 2015
Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior Fulltext Access 6 Pages 2015
A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma Fulltext Access 6 Pages 2015
Analytical protocol for the sensitive determination of mannitol, sorbitol and glucose containing powders in pharmaceutical workplaces by ion chromatography using a pulsed amperometric detector Fulltext Access 6 Pages 2015
Analysis of amino acid neurotransmitters from rat and mouse spinal cords by liquid chromatography with fluorescence detection Fulltext Access 6 Pages 2015
Studies on the kinetics of carbamazepine degradation in aqueous matrix in the course of modified Fenton's reactions Fulltext Access 6 Pages 2015
Determination of carnitine and acylcarnitines in human urine by means of microextraction in packed sorbent and hydrophilic interaction chromatography-ultra-high-performance liquid chromatography-tandem mass spectrometry Fulltext Access 6 Pages 2015
Simultaneous determination of propofol and its glucuronide in whole blood by liquid chromatography-electrospray tandem mass spectrometry and the influence of sample storage conditions on the reliability of the test results Fulltext Access 6 Pages 2015
Metabolism study of boldenone in human urine by gas chromatography-tandem mass spectrometry Fulltext Access 6 Pages 2015
A new methodology for the determination of enzyme activity based on carbon nanotubes and glucose oxidase Fulltext Access 6 Pages 2015
Biarylmethoxy 2-nitroimidazooxazine antituberculosis agents: Effects of proximal ring substitution and linker reversal on metabolism and efficacy Fulltext Access 6 Pages 2015
Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4 Fulltext Access 6 Pages 2015
Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2 Fulltext Access 6 Pages 2015
Synthesis of novel cationic spermine-conjugated phosphotriester oligonucleotide for improvement of cell membrane permeability Fulltext Access 6 Pages 2015
Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approach Fulltext Access 6 Pages 2015
Novel neurotrophic phenylbutenoids from Indonesian ginger Bangle, Zingiber purpureum Fulltext Access 6 Pages 2015
Pancreatic lipase inhibitory constituents from Morus alba leaves and optimization for extraction conditions Fulltext Access 6 Pages 2015
Synthesis and biological evaluation of phaitanthrin congeners as anti-mycobacterial agents Fulltext Access 6 Pages 2015
Structure-based design and optimization of potent inhibitors of the adenoviral protease Fulltext Access 6 Pages 2015
Improving the passive permeability of macrocyclic peptides: Balancing permeability with other physicochemical properties Fulltext Access 6 Pages 2015
Identification of the dioxygenase-generated intermediate formed during biosynthesis of the dihydropyrrole moiety common to anthramycin and sibiromycin Fulltext Access 6 Pages 2015
Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives Fulltext Access 6 Pages 2015
A long-term stability study of Prussian blue: A quality assessment of water content and cesium binding Fulltext Access 6 Pages 2015
Effect of drying methods on the free and conjugated bufadienolide content in toad venom determined by ultra-performance liquid chromatography-triple quadrupole mass spectrometry coupled with a pattern recognition approach Fulltext Access 6 Pages 2015
Development and beyond: Strategy for long-term maintenance of an online laser diffraction particle size method in a spray drying manufacturing process Fulltext Access 6 Pages 2015
Liposome-like nanocapsules of dual drug-tailed betaine for cancer therapy Fulltext Access 6 Pages 2015
Biological stimuli-responsive cyclodextrin-based host–guest nanosystems for cancer therapy Fulltext Access 6 Pages 2015
A geometric pore adsorption model for predicting the drug loading capacity of insoluble drugs in mesoporous carbon Fulltext Access 6 Pages 2015
Can preschool-aged children swallow several minitablets at a time? Results from a clinical pilot study Fulltext Access 6 Pages 2015
Asymmetric lipid–polymer particles (LIPOMER) by modified nanoprecipitation: role of non-solvent composition Fulltext Access 6 Pages 2015
Estimation of Young’s modulus of pharmaceutical tablet obtained by terahertz time-delay measurement Fulltext Access 6 Pages 2015
Development and evaluation of a tampering resistant transdermal fentanyl patch Fulltext Access 6 Pages 2015
Investigation of microemulsion microstructure and its impact on skin delivery of flufenamic acid Fulltext Access 6 Pages 2015
The use of dynamic thermal analysis to distinguish between genuine and counterfeit drugs Fulltext Access 6 Pages 2015
Measuring drug saturation solubility in thin polymer films: Use of a thin acceptor layer Fulltext Access 6 Pages 2015
Comparison of the osteogenic differentiation potential of mesenchymal cells isolated from human bone marrow, umbilical cord blood and placenta derived stem cells Fulltext Access 6 Pages 2015
Potential of aerosolized rifampicin lipospheres for modulation of pulmonary pharmacokinetics and bio-distribution Fulltext Access 6 Pages 2015
Targeting apoptotic machinery as approach for anticancer therapy: Smac mimetics as anticancer agents Fulltext Access 6 Pages 2015
The Polymorphic Phase Transformations in the Chlorpropamide under Pressure Fulltext Access 6 Pages 2015
A Sensitive Medium-Throughput Method to Predict Intestinal Absorption in Humans Using Rat Intestinal Tissue Segments Fulltext Access 6 Pages 2015
Multiple Linear Regression Analysis Indicates Association of P-Glycoprotein Substrate or Inhibitor Character with Bitterness Intensity Measured with a Sensor Fulltext Access 6 Pages 2015