Enhancement of ghrelin-signaling system by Rikkunshi-To attenuates teriparatide-induced pica in rats Fulltext Access 9 Pages 2018
Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude Fulltext Access 9 Pages 2018
Cynomorium songaricum prevents bone resorption in ovariectomized rats through RANKL/RANK/TRAF6 mediated suppression of PI3K/AKT and NF-κB pathways Fulltext Access 9 Pages 2018
Regulation of apolipoprotein A-I gene expression by the histamine H1 receptor: Requirement for NF-κB Fulltext Access 9 Pages 2018
Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation Fulltext Access 9 Pages 2018
Norbixin, an apocarotenoid derivative activates PPARγ in cardiometabolic syndrome: Validation by in silico and in vivo experimental assessment Fulltext Access 9 Pages 2018
Sevoflurane affects neurogenesis through cell cycle arrest via inhibiting wnt/β-catenin signaling pathway in mouse neural stem cells Fulltext Access 9 Pages 2018
MiR-302b regulates cell functions and acts as a potential biomarker to predict recurrence in bladder cancer Fulltext Access 9 Pages 2018
Oligo-peptide I-C-F-6 inhibits hepatic stellate cell activation and ameliorates CCl4-induced liver fibrosis by suppressing NF-κB signaling and Wnt/β-catenin signaling Fulltext Access 9 Pages 2018
Matrix Gla protein negatively regulates calcification of human aortic valve interstitial cells isolated from calcified aortic valves Fulltext Access 9 Pages 2018
Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator Fulltext Access 9 Pages 2018
Atractylodin attenuates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome and TLR4 pathways Fulltext Access 9 Pages 2018
Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice Fulltext Access 9 Pages 2018
Silencing of PHLPP1 promotes neuronal apoptosis and inhibits functional recovery after spinal cord injury in mice Fulltext Access 9 Pages 2018
Toxicological evaluation of an aqueous suspension from leaves and stems of Petiveria alliacea L. (Phytolaccaceae) Fulltext Access 9 Pages 2018
Extraction, fractionation and re-fractionation of Artemisia nilagirica for anticancer activity and HPLC-ESI-QTOF-MS/MS determination Fulltext Access 9 Pages 2018
Dihydrofisetin exerts its anti-inflammatory effects associated with suppressing ERK/p38 MAPK and Heme Oxygenase-1 activation in lipopolysaccharide-stimulated RAW 264.7 macrophages and carrageenan-induced mice paw edema Fulltext Access 9 Pages 2018
Scutellarin alleviates lipopolysaccharide-induced cognitive deficits in the rat: Insights into underlying mechanisms Fulltext Access 9 Pages 2018
Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-ĸB pathways Fulltext Access 9 Pages 2018
Paeoniflorin inhibits VSMCs proliferation and migration by arresting cell cycle and activating HO-1 through MAPKs and NF-κB pathway Fulltext Access 9 Pages 2018
Down-regulation of Notch signaling pathway reverses the Th1/Th2 imbalance in tuberculosis patients Fulltext Access 9 Pages 2018
Blocking osteopontin-fibronectin interactions reduce extracellular fibronectin deployment and arthritic immunopathology Fulltext Access 9 Pages 2018
EFhd2/swiprosin-1 regulates LPS-induced macrophage recruitment via enhancing actin polymerization and cell migration Fulltext Access 9 Pages 2018
Kaempferol inhibits the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes by blocking activation of the MAPK pathway Fulltext Access 9 Pages 2018
A prenylated flavonoid, 10-oxomornigrol F, exhibits anti-inflammatory effects by activating the Nrf2/heme oxygenase-1 pathway in macrophage cells Fulltext Access 9 Pages 2018
Phytochemical and genetic characterization of styles of wild Crocus species from the island of Crete, Greece and comparison to those of cultivated C. sativus Fulltext Access 9 Pages 2018
New inhibitors of matrix metalloproteinases 9 (MMP-9): Lignans from Selaginella moellendorffii Fulltext Access 9 Pages 2018
Ent-abietanes from the Godavari mangrove, Ceriops decandra: Absolute configuration and NF-κB inhibitory activity Fulltext Access 9 Pages 2018
Contribution of IL-1β, 6 and TNF-α to the form of post-traumatic osteoarthritis induced by “idealized” anterior cruciate ligament reconstruction in a porcine model Fulltext Access 9 Pages 2018
Differentiated HASTR/ci35 cells: A promising in vitro human astrocyte model for facilitating CNS drug development studies Fulltext Access 9 Pages 2018
Inhibition effect of glycyrrhiza polysaccharide (GCP) on tumor growth through regulation of the gut microbiota composition Fulltext Access 9 Pages 2018
A new diethylcarbamazine formulation (NANO-DEC) as a therapeutic tool for hepatic fibrosis Fulltext Access 9 Pages 2018
Interleukin 33 ameliorates disturbance of regulatory T cells in pulmonary sarcoidosis Fulltext Access 9 Pages 2018
High fat diet modulates inflammatory parameters in the heart and liver during acute Trypanosoma cruzi infection Fulltext Access 9 Pages 2018
A novel Gallic acid derivative attenuates BLM-induced pulmonary fibrosis in mice Fulltext Access 9 Pages 2018
Piceatannol attenuates D-GalN/LPS-induced hepatoxicity in mice: Involvement of ER stress, inflammation and oxidative stress Fulltext Access 9 Pages 2018
Melatonin inhibits endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in lipopolysaccharide-induced endometritis in mice Fulltext Access 9 Pages 2018
Attenuation of antimalarial agent hydroxychloroquine on TNF-α-induced endothelial inflammation Fulltext Access 9 Pages 2018
Andrographolide sulfonate reduces mortality in Enterovirus 71 infected mice by modulating immunity Fulltext Access 9 Pages 2018
Osthole inhibits pancreatic cancer progression by directly exerting negative effects on cancer cells and attenuating tumor-infiltrating M2 macrophages Fulltext Access 9 Pages 2018
Mangiferin inhibits high-fat diet induced vascular injury via regulation of PTEN/AKT/eNOS pathway Fulltext Access 9 Pages 2018
Imiquimod enhances the potency of an exogenous BM-DC based vaccine against mouse melanoma Fulltext Access 9 Pages 2018
Impacts of simultaneous exposure to arsenic (III) and copper (II) on inflammatory response, immune homeostasis, and heat shock response in chicken thymus Fulltext Access 9 Pages 2018
The activation of Toll-like receptor 4 reverses tumor differentiation in human glioma U251 cells via Notch pathway Fulltext Access 9 Pages 2018
BF211, a derivative of bufalin, enhances the cytocidal effects in multiple myeloma cells by inhibiting the IL-6/JAK2/STAT3 pathway Fulltext Access 9 Pages 2018
Differential regulation of MyD88- and TRIF-dependent signaling pathways of Toll-like receptors by cardamonin Fulltext Access 9 Pages 2018
Microtubular remodeling and decreased expression of Nav1.5 with enhanced EHD4 in cells from the infarcted heart Fulltext Access 9 Pages 2018
Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition Fulltext Access 9 Pages 2018
Puerarin attenuates palmitate-induced mitochondrial dysfunction, impaired mitophagy and inflammation in L6 myotubes Fulltext Access 9 Pages 2018
Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-α and CXCL-1 Fulltext Access 9 Pages 2018
Four new hybrid polyketide-terpenoid metabolites from the Penicillium sp. SYPF7381 in the rhizosphere soil of Pulsatilla chinensis Fulltext Access 9 Pages 2018
Arundinosides A-G, new glucosyloxybenzyl 2R-benzylmalate derivatives from the aerial parts of Arundina graminifolia Fulltext Access 9 Pages 2018
Polyphenolic profile and biological activities of black carrot crude extract (Daucus carota L. ssp. sativus var. atrorubens Alef.) Fulltext Access 9 Pages 2018
(19αH)-lupane and (9βH)-lanostane triterpenes from Euphorbia helioscopia trigger apoptosis of tumor cell Fulltext Access 9 Pages 2018
Dehydroabietic acid isolated from Pinus elliottii exerts in vitro antileishmanial action by pro-oxidant effect, inducing ROS production in promastigote and downregulating Nrf2/ferritin expression in amastigote forms of Leishmania amazonensis Fulltext Access 9 Pages 2018
Evaluation of in vitro/in vivo anti-diabetic effects and identification of compounds from Physalis alkekengi Fulltext Access 9 Pages 2018
New zwitterionic monoterpene indole alkaloids from Uncaria rhynchophylla Fulltext Access 9 Pages 2018
A strategy to improve the oral availability of baicalein: The baicalein-theophylline cocrystal Fulltext Access 9 Pages 2018
Design, synthesis, and anti-inflammatory activity of caffeoyl salicylate analogs as NO production inhibitors Fulltext Access 9 Pages 2018
New secondary metabolites from an engineering mutant of endophytic Streptomyces sp. CS Fulltext Access 9 Pages 2018
Over-expressed miRNA-200b ameliorates ulcerative colitis-related colorectal cancer in mice through orchestrating epithelial-mesenchymal transition and inflammatory responses by channel of AKT2 Fulltext Access 9 Pages 2018
The comprehensive electrophysiological study of curcuminoids on delayed-rectifier K+ currents in insulin-secreting cells Fulltext Access 9 Pages 2018
IL-1β augments H2S-induced increase in intracellular Ca2+ through polysulfides generated from H2S/NO interaction Fulltext Access 9 Pages 2018
Evaluation of pharmacokinetics/pharmacodynamics and efficacy of one-month depots of TAK-448 and TAK-683, investigational kisspeptin analogs, in male rats and an androgen-dependent prostate cancer model Fulltext Access 9 Pages 2018
Antagonism of corticotropin-releasing factor CRF1 receptors blocks the enhanced response to cocaine after social stress Fulltext Access 9 Pages 2018
Analysis of the pharmacological properties of JWH-122 isomers and THJ-2201, RCS-4 and AB-CHMINACA in HEK293T cells and hippocampal neurons Fulltext Access 9 Pages 2018
Inhibition of gingipains prevents Porphyromonas gingivalis-induced preterm birth and fetal death in pregnant mice Fulltext Access 9 Pages 2018
A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1 Fulltext Access 9 Pages 2018
Deubiquitinase inhibitor b-AP15 activates endoplasmic reticulum (ER) stress and inhibits Wnt/Notch1 signaling pathway leading to the reduction of cell survival in hepatocellular carcinoma cells Fulltext Access 9 Pages 2018
Ameliorating effect of TI-1-162, a hydroxyindenone derivative, against TNBS-induced rat colitis is mediated through suppression of RIP/ASK-1/MAPK signaling Fulltext Access 9 Pages 2018
In vitro and in vivo functional profile characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3-carboxamido)morphinan (NAQ) as a low efficacy mu opioid receptor modulator Fulltext Access 9 Pages 2018
Amelioration of collagen antibody induced arthritis in mice by an antibody directed against the fibronectin type III repeats of tenascin-C Fulltext Access 9 Pages 2018
Reduced inflammatory factor expression facilitates recovery after sciatic nerve injury in TLR4 mutant mice Fulltext Access 9 Pages 2018
AT-RVD1 repairs mouse lung after cigarette smoke-induced emphysema via downregulation of oxidative stress by NRF2/KEAP1 pathway Fulltext Access 9 Pages 2018
Lactobacillus plantarum AN1 cells increase caecal L. reuteri in an ICR mouse model of dextran sodium sulphate-induced inflammatory bowel disease Fulltext Access 9 Pages 2018
siRNA-mediated c-Rel knockdown ameliorates collagen-induced arthritis in mice Fulltext Access 9 Pages 2018
Circulating CD14+CD163+CD115+ M2 monocytes are associated with the severity of new onset severe acute pancreatitis in Chinese patients Fulltext Access 9 Pages 2018
Andrographolide suppresses TRIF-dependent signaling of toll-like receptors by targeting TBK1 Fulltext Access 9 Pages 2018
Andrographolide derivative CX-10 ameliorates dextran sulphate sodium-induced ulcerative colitis in mice: Involvement of NF-κB and MAPK signalling pathways Fulltext Access 9 Pages 2018
Inhibitor of Bruton's tyrosine kinases, PCI-32765, decreases pro-inflammatory mediators' production in high glucose-induced macrophages Fulltext Access 9 Pages 2018
Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways Fulltext Access 9 Pages 2018
Protective effects of ginsenoside Rg1 on splenocytes and thymocytes in an aging rat model induced by d-galactose Fulltext Access 9 Pages 2018
Toll-like receptor 2 stimulation promotes colorectal cancer cell growth via PI3K/Akt and NF-κB signaling pathways Fulltext Access 9 Pages 2018
Metformin, a first-line drug for type 2 diabetes mellitus, disrupts the MALAT1/miR-142-3p sponge to decrease invasion and migration in cervical cancer cells Fulltext Access 9 Pages 2018
Long non-coding RNA NEAT1 plays an important role in sepsis-induced acute kidney injury by targeting miR-204 and modulating the NF-κB pathway Fulltext Access 9 Pages 2018
Glabridin, an isoflavan from licorice root, ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice Fulltext Access 9 Pages 2018
IL-17 inhibits the accumulation of myeloid-derived suppressor cells in breast cancer via activating STAT3 Fulltext Access 9 Pages 2018
Enhancement of Th1 immune response against Leishmania cysteine peptidase A, B by PLGA nanoparticle Fulltext Access 9 Pages 2018
Protective effect of pristimerin against LPS-induced acute lung injury in mice Fulltext Access 9 Pages 2018
C5a receptor1 inhibition alleviates influenza virus-induced acute lung injury Fulltext Access 9 Pages 2018
Fisetin inhibits the generation of inflammatory mediators in interleukin-1β-induced human lung epithelial cells by suppressing the NF-κB and ERK1/2 pathways Fulltext Access 9 Pages 2018
Down-regulation of IFIT3 protects liver from ischemia-reperfusion injury Fulltext Access 9 Pages 2018
New peptide MY1340 revert the inhibition effect of VEGF on dendritic cells differentiation and maturation via blocking VEGF-NRP-1 axis and inhibit tumor growth in vivo Fulltext Access 9 Pages 2018
Nasal vaccination with pneumococcal surface protein A in combination with cationic liposomes consisting of DOTAP and DC-chol confers antigen-mediated protective immunity against Streptococcus pneumoniae infections in mice Fulltext Access 9 Pages 2018
Comparison of lactate and β-hydroxybutyrate in the treatment of concanavalin-A induced hepatitis Fulltext Access 9 Pages 2018