Contraction-dependent TGF-β1 activation is required for thrombin-induced remodeling in human airway smooth muscle cells Fulltext Access 10 Pages 2018
Is selective 5-HT1F receptor agonism an entity apart from that of the triptans in antimigraine therapy? Fulltext Access 10 Pages 2018
Probiotics and antibiotic-associated diarrhea in children: A review and new evidence on Lactobacillus rhamnosus GG during and after antibiotic treatment Fulltext Access 10 Pages 2018
Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-α/IFN-γ-induced inflammatory response in keratinocytes and T cell-derived IL-17 Fulltext Access 10 Pages 2018
Structural patterns of the human ABCC4/MRP4 exporter in lipid bilayers rationalize clinically observed polymorphisms Fulltext Access 10 Pages 2018
Effects of bronchodilation on biomarkers of peripheral airway inflammation in COPD Fulltext Access 10 Pages 2018
Synthesis of silver nanoparticles using aqueous extract of Dolichos lablab for reduction of 4-Nitrophenol, antimicrobial and anticancer activities Fulltext Access 10 Pages 2018
TGF-β1 signaling regulates mouse hepatic stellate cell differentiation via the Jagged1/Notch pathway Fulltext Access 10 Pages 2018
Interval exercise training increases LIF expression and prevents myocardial infarction-induced skeletal muscle atrophy in rats Fulltext Access 10 Pages 2018
Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons Fulltext Access 10 Pages 2018
Focusing on long non-coding RNA dysregulation in newly diagnosed multiple myeloma Fulltext Access 10 Pages 2018
Atherogenic diet induced lipid accumulation induced NFκB level in heart, liver and brain of Wistar rat and diosgenin as an anti-inflammatory agent Fulltext Access 10 Pages 2018
Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells Fulltext Access 10 Pages 2018
In vitro study of FUZ as a novel potential therapeutic target in non-small-cell lung cancer Fulltext Access 10 Pages 2018
The anti-diabetic drug dapagliflozin induces vasodilation via activation of PKG and Kv channels Fulltext Access 10 Pages 2018
Alendronate augments lipid A-induced IL-1β release and Smad3/NLRP3/ASC-dependent cell death Fulltext Access 10 Pages 2018
Gut inflammation exacerbates hepatic injury in the high-fat diet induced NAFLD mouse: Attention to the gut-vascular barrier dysfunction Fulltext Access 10 Pages 2018
Spleen tyrosine kinase inhibition ameliorates airway inflammation through modulation of NLRP3 inflammosome and Th17/Treg axis Fulltext Access 10 Pages 2018
MiR-150-5p regulates EGR2 to promote the development of chronic rhinosinusitis via the DC-Th axis Fulltext Access 10 Pages 2018
Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect Fulltext Access 10 Pages 2018
Elevated expression of miR-146, miR-139 and miR-340 involved in regulating Th1/Th2 balance with acute exposure of fine particulate matter in mice Fulltext Access 10 Pages 2018
Protocatechuic acid inhibits Toll-like receptor-4-dependent activation of NF-κB by suppressing activation of the Akt, mTOR, JNK and p38-MAPK Fulltext Access 10 Pages 2018
Mogroside IVE attenuates experimental liver fibrosis in mice and inhibits HSC activation through downregulating TLR4-mediated pathways Fulltext Access 10 Pages 2018
Acute and 28-day sub-acute intravenous toxicity studies of 1'-S-1â²-acetoxychavicol acetate in rats Fulltext Access 10 Pages 2018
MiR-155 inhibition ameliorates 2, 4, 6-Trinitrobenzenesulfonic acid (TNBS)-induced experimental colitis in rat via influencing the differentiation of Th17 cells by Jarid2 Fulltext Access 10 Pages 2018
Effect of celastrol on the progression of polycystic kidney disease in a Pkd1-deficient mouse model Fulltext Access 10 Pages 2018
Enhanced neutrophil autophagy and increased concentrations of IL-6, IL-8, IL-10 and MCP-1 in rheumatoid arthritis Fulltext Access 10 Pages 2018
Leonurine inhibits IL-1β induced inflammation in murine chondrocytes and ameliorates murine osteoarthritis Fulltext Access 10 Pages 2018
Effect of Fluconazole on the Pharmacokinetic Properties of Imrecoxib, a Novel NSAID: A Single-center, Open-label, Self-controlled Study in Healthy Chinese Male Volunteers Fulltext Access 10 Pages 2018
MERS: Progress on the global response, remaining challenges and the way forward Fulltext Access 10 Pages 2018
Botryosphaeran reduces obesity, hepatic steatosis, dyslipidaemia, insulin resistance and glucose intolerance in diet-induced obese rats Fulltext Access 10 Pages 2018
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-κB activation Fulltext Access 10 Pages 2018
Honokiol protects pulmonary microvascular endothelial barrier against lipopolysaccharide-induced ARDS partially via the Sirt3/AMPK signaling axis Fulltext Access 10 Pages 2018
Lisinopril inhibits nuclear transcription factor kappa B and augments sensitivity to silymarin in experimental liver fibrosis Fulltext Access 10 Pages 2018
Anandamide inhibits FcεRI-dependent degranulation and cytokine synthesis in mast cells through CB2 and GPR55 receptor activation. Possible involvement of CB2-GPR55 heteromers Fulltext Access 10 Pages 2018
Diarylheptanoid from rhizomes of Curcuma kwangsiensis (DCK) inhibited imiquimod-induced dendritic cells activation and Th1/Th17 differentiation Fulltext Access 10 Pages 2018
Targeting myeloid-derived suppressor cells using all-trans retinoic acid in melanoma patients treated with Ipilimumab Fulltext Access 10 Pages 2018
Linoorbitides and enterolactone mitigate inflammation-induced oxidative stress and loss of intestinal epithelial barrier integrity Fulltext Access 10 Pages 2018
Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice Fulltext Access 10 Pages 2018
Development, qualification, validation and application of the Ames test using a VITROCELL® VC10® smoke exposure system Fulltext Access 10 Pages 2018
Bioactive profiling and therapeutic potential of mushroom (Pleurotus tuberregium) extract on Wistar albino rats (Ratus norvegicus) exposed to arsenic and chromium toxicity Fulltext Access 10 Pages 2018
New research highlights: Impact of chronic ingestion of white kidney beans (Phaseolus vulgaris L. var. Beldia) on small-intestinal disaccharidase activity in Wistar rats Fulltext Access 10 Pages 2018
Evaluation of acute and sublethal effects of chloroquine (C18H26CIN3) on certain enzymological and histopathological biomarker responses of a freshwater fish Cyprinus carpio Fulltext Access 10 Pages 2018
Selective inhibition of CTCF binding by iAs directs TET-mediated reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells Fulltext Access 10 Pages 2018
Disposition of β-N-methylamino-l-alanine (L-BMAA), a neurotoxin, in rodents following a single or repeated oral exposure Fulltext Access 10 Pages 2018
Intestinal exposure to PCB 153 induces inflammation via the ATM/NEMO pathway Fulltext Access 10 Pages 2018
p-Cresyl sulfate decreases peripheral B cells in mice with adenine-induced renal dysfunction Fulltext Access 10 Pages 2018
Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization Fulltext Access 10 Pages 2018
Exposure- and Dose-response Analyses in Dose Selection and Labeling of FDA-approved Biologics Fulltext Access 10 Pages 2018
Effects of Nemonoxacin on Thorough ECG QT/QTc Interval: A Randomized, Placebo- and Positive-controlled Crossover Study in Healthy Chinese Adults Fulltext Access 10 Pages 2018
Effect of Automated Bolus Calculation on Glucose Variability and Quality of Life in Patients With Type 1 Diabetes on CSII Treatment Fulltext Access 10 Pages 2018
Auxiliary subunits of AMPA receptors: The discovery of a forebrain-selective antagonist, LY3130481/CERC-611 Fulltext Access 10 Pages 2018
Doxorubicin resistance in breast cancer: A novel role for the human protein AHNAK Fulltext Access 10 Pages 2018
Endogenous hydrogen sulfide regulates histone demethylase JMJD3-mediated inflammatory response in LPS-stimulated macrophages and in a mouse model of LPS-induced septic shock Fulltext Access 10 Pages 2018
Is there a role of H2S in mediating health span benefits of caloric restriction? Fulltext Access 10 Pages 2018
Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications Fulltext Access 10 Pages 2018
PBA2 exhibits potent anti-tumor activity via suppression of VEGFR2 mediated-cell proliferation and angiogenesis Fulltext Access 10 Pages 2018
Differential patterns of inhibition of the sugar transporters GLUT2, GLUT5 and GLUT7 by flavonoids Fulltext Access 10 Pages 2018
Forskolin improves sensitivity to doxorubicin of triple negative breast cancer cells via Protein Kinase A-mediated ERK1/2 inhibition Fulltext Access 10 Pages 2018
Selective killing of proinflammatory synovial fibroblasts via activation of transient receptor potential ankyrin (TRPA1) Fulltext Access 10 Pages 2018
Development of novel anti-CD19 antibody-drug conjugates for B-cell lymphoma treatment Fulltext Access 10 Pages 2018
In vitro approach to elucidate the relevance of carboxylesterase 2 and N-acetyltransferase 2 to flupirtine-induced liver injury Fulltext Access 10 Pages 2018
Effects of n-3 PUFA enriched and n-3 PUFA deficient diets in naïve and Aβ-treated female rats Fulltext Access 10 Pages 2018
Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB Fulltext Access 10 Pages 2018
Interactions of endocannabinoid virodhamine and related analogs with human monoamine oxidase-A and -B Fulltext Access 10 Pages 2018
Multitargeted kinase inhibitors imatinib, sorafenib and sunitinib perturb energy metabolism and cause cytotoxicity to cultured C2C12 skeletal muscle derived myotubes Fulltext Access 10 Pages 2018
The diverse functions of the hepatitis B core/capsid protein (HBc) in the viral life cycle: Implications for the development of HBc-targeting antivirals Fulltext Access 10 Pages 2018
Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection Fulltext Access 10 Pages 2018
Evaluation of ODE-Bn-PMEG, an acyclic nucleoside phosphonate prodrug, as an antiviral against productive HPV infection in 3D organotypic epithelial cultures Fulltext Access 10 Pages 2018
Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation Fulltext Access 10 Pages 2018
A cross-sectional survey of the access of older people in the Scottish Highlands to general medical practices, community pharmacies and prescription medicines Fulltext Access 10 Pages 2018
20(R)-ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen-induced hepatotoxicity by suppressing PI3K/AKT pathway-mediated inflammation and apoptosis Fulltext Access 10 Pages 2018
Dexamethasone restores transforming growth factor-β activated kinase 1 expression and phagocytosis activity of Kupffer cells in cholestatic liver injury Fulltext Access 10 Pages 2018
GLMEEMSAL epitope common in different isoforms of hMena elicits in vitro activation of cytotoxic T cells and stimulates specific antitumor immunity in BALB/c mice Fulltext Access 10 Pages 2018
Endocytosis of particulate matter induces cytokine production by neutrophil via Toll-like receptor 4 Fulltext Access 10 Pages 2018
Substance P-regulated leukotriene B4 production promotes acute pancreatitis-associated lung injury through neutrophil reverse migration Fulltext Access 10 Pages 2018
In vitro uptake of oligomannose-coated liposomes leads to differentiation of inflammatory monocytes into mature antigen-presenting cells that can activate T cells Fulltext Access 10 Pages 2018
XQ-1H protects against ischemic stroke by regulating microglia polarization through PPARγ pathway in mice Fulltext Access 10 Pages 2018
Kaempferol-3-o-β-d-glucuronate exhibit potential anti-inflammatory effect in LPS stimulated RAW 264.7 cells and mice model Fulltext Access 10 Pages 2018
The positive effects of secreting cytokines IL-17 and IFN-γ on the early-stage differentiation and negative effects on the calcification of primary osteoblasts in vitro Fulltext Access 10 Pages 2018
B7-H6 expression is induced by lipopolysaccharide and facilitates cancer invasion and metastasis in human gliomas Fulltext Access 10 Pages 2018
Phosphorylation of low density lipoprotein receptor-related protein 6 is involved in receptor for advanced glycation end product-mediated β-catenin stabilization in a toluene diisocyanate-induced asthma model Fulltext Access 10 Pages 2018
Pseudolaric acid B attenuates atherosclerosis progression and inflammation by suppressing PPARγ-mediated NF-κB activation Fulltext Access 10 Pages 2018
A review of DTCA techniques: Appraising their success and potential impact on medication users Fulltext Access 10 Pages 2018
Orally administered brown seaweed-derived β-glucan effectively restrained development of gastric dysplasia in A4gnt KO mice that spontaneously develop gastric adenocarcinoma Fulltext Access 10 Pages 2018
HIV aspartyl protease inhibitors modify the percentage of activated leukocytes, as well as serum levels of IL-17A and NO during experimental leishmaniasis Fulltext Access 10 Pages 2018
MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model Fulltext Access 10 Pages 2018
Harmine, a small molecule derived from natural sources, inhibits enterovirus 71 replication by targeting NF-κB pathway Fulltext Access 10 Pages 2018
Development of a new approach of immunotherapy against scorpion envenoming: Avian IgYs an alternative to equine IgGs Fulltext Access 10 Pages 2018
Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic inflammatory disorders Fulltext Access 10 Pages 2018
Formyl peptide receptor activation inhibits the expansion of effector T cells and synovial fibroblasts and attenuates joint injury in models of rheumatoid arthritis Fulltext Access 10 Pages 2018
MSCs protect endothelial cells from inflammatory injury partially by secreting STC1 Fulltext Access 10 Pages 2018
Design, synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives Fulltext Access 10 Pages 2018
Targeting RAW 264.7 macrophages (M1 type) with Withaferin-A decorated mannosylated liposomes induces repolarization via downregulation of NF-κB and controlled elevation of STAT-3 Fulltext Access 10 Pages 2018
Combination of TLR8 and TLR4 agonists reduces the degrading effects of nicotine on DC-NK mediated effector T cell generation Fulltext Access 10 Pages 2018