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Pharmacology Research Articles

Anticancer effect of petroleum ether extract from Bidens pilosa L and its constituent's analysis by GC-MS
Fulltext Access 25 Pages 2018
FcγRI (CD64) contributes to the severity of immune inflammation through regulating NF-κB/NLRP3 inflammasome pathway
Fulltext Access 25 Pages 2018
Pleiotropic roles of the ubiquitin-proteasome system during viral propagation
Fulltext Access 25 Pages 2018
Dioscin ameliorates cardiac hypertrophy through inhibition of the MAPK and Akt/GSK3β/mTOR pathways
Fulltext Access 25 Pages 2018
Long noncoding RNA SNHG6 regulates p21 expression via activation of the JNK pathway and regulation of EZH2 in gastric cancer cells
Fulltext Access 25 Pages 2018
Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: In vivo and in vitro studies
Fulltext Access 25 Pages 2018
Molecular modeling studies of coruscanone (A) core nucleus as potential antifungal agents
Fulltext Access 25 Pages 2018
Real time monitoring and quantification of reactive oxygen species in breast cancer cell line MCF-7 by 2′,7′-dichlorofluorescin diacetate (DCFDA) assay
Fulltext Access 25 Pages 2018
Curcuma comosa reduces visceral adipose tissue and improves dyslipidemia in ovariectomized rats
Fulltext Access 25 Pages 2018
Bioactive fraction of Rhodiola algida against chronic hypoxia-induced pulmonary arterial hypertension and its anti-proliferation mechanism in rats
Fulltext Access 25 Pages 2018
Improvement of Cisplatin-induced renal dysfunction by Schisandra chinensis stems via anti-inflammation and anti-apoptosis effects
Fulltext Access 25 Pages 2018
The role of HBV-induced autophagy in HBV replication and HBV related-HCC
Fulltext Access 25 Pages 2018
Castanea mollissima shell prevents an over expression of inflammatory response and accelerates the dermal wound healing
Fulltext Access 25 Pages 2018
Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells
Fulltext Access 25 Pages 2018
Lipophilic extracts of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibit key enzymes involved in inflammation and gout
Fulltext Access 25 Pages 2018
Anti-Deinagkistrodon acutus venom properties of ethanolic root extract from Cynanchum paniculatum (Bunge) kitag and its GC-MS analysis
Fulltext Access 25 Pages 2018
Analysis of chemical composition and in vitro antidermatophyte activity of ethanol extracts of Dryopteris fragrans (L.) Schott
Fulltext Access 25 Pages 2018
Euphorbia kansui fry-baked with vinegar modulates gut microbiota and reduces intestinal toxicity in rats
Fulltext Access 25 Pages 2018
Ginkgolide K promotes astrocyte proliferation and migration after oxygen-glucose deprivation via inducing protective autophagy through the AMPK/mTOR/ULK1 signaling pathway
Fulltext Access 25 Pages 2018
The role of verapamil and SL-327 in morphine- and ethanol-induced state-dependent and cross state-dependent memory
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Role of nitric oxide and KATP channel in the protective effect mediated by nicorandil in bile duct ligation-induced liver fibrosis in rats
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LncRNA HOX transcript antisense RNA accelerated kidney injury induced by urine-derived sepsis through the miR-22/high mobility group box 1 pathway
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Inhibition of catechol-O-methyltransferase in the cynomolgus monkey by opicapone after acute and repeated administration
Fulltext Access 25 Pages 2018
The WHO R&D Blueprint: 2018 review of emerging infectious diseases requiring urgent research and development efforts
Fulltext Access 25 Pages 2018
The role of (E)-6-chloro-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-2-styrylquinazolin-4(3H)-one in the modulation of cannabinoidergic system. A pilot study
Fulltext Access 25 Pages 2018
Metabolomic and biotechnological approaches to determine therapeutic potential of Withania somnifera (L.) Dunal: A review
Fulltext Access 25 Pages 2018
Ganglioside GD3 synthase (GD3S), a novel cancer drug target
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Preliminary analysis of the effect of Stevia (Stevia rebaudiana) in patients with chronic kidney disease (stage I to stage III)
Fulltext Access 25 Pages 2018
Neuronal mechanisms mediating pathological reward-related behaviors: A focus on silent synapses in the nucleus accumbens
Fulltext Access 25 Pages 2018
A PK/PD study of Delta-4 abiraterone metabolite in metastatic castration-resistant prostate cancer patients
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Integrated microarray meta-analysis identifies miRNA-27a as an oncogene in ovarian cancer by inhibiting FOXO1
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Combined treatment with aripiprazole and antidepressants reversed some MK-801-induced schizophrenia-like symptoms in mice
Fulltext Access 25 Pages 2018
Protein phosphatase 2A as therapeutic targets in various disease models
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Zebrafish models: do we have valid paradigms for depression?
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The mechanisms behind decreased internalization of angiotensin II type 1 receptor
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The influence of CYP1A2 genotype in the blood pressure response to caffeine ingestion is affected by physical activity status and caffeine consumption level
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Histamine H4 receptor antagonism prevents the progression of diabetic nephropathy in male DBA2/J mice
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Highlighting the endoplasmic reticulum-mitochondria connection: Focus on Mitofusin 2
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Minocycline as a promising therapeutic strategy for chronic pain
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Dose-dependent target diversion of Danhong injection on the Glu-GLT-1/Gly-GlyRα dynamic balance module of cerebral ischemia
Fulltext Access 25 Pages 2018
Neuroprotective effect of epalrestat mediated through oxidative stress markers, cytokines and TAU protein levels in diabetic rats
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Establishment of a reverse genetics system for duck Tembusu virus to study virulence and screen antiviral genes
Fulltext Access 25 Pages 2018
Tapentadol - A representative of a new class of MOR-NRI analgesics
Fulltext Access 25 Pages 2018
The importance of chemokines in neuropathic pain development and opioid analgesic potency
Fulltext Access 25 Pages 2018
Sensorimotor gating deficits and effects of antipsychotics on the hyperactivity in VGF-overexpressing mice
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Alpinumisoflavone rescues glucocorticoid-induced apoptosis of osteocytes via suppressing Nox2-dependent ROS generation
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5-Fluororacil-Induced Gastrointestinal Damage Impairs the Absorption and Anticoagulant Effects of Dabigatran Etexilate
Fulltext Access 25 Pages 2018
Fibroblast growth factor 20 is protective towards dopaminergic neurons in vivo in a paracrine manner
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Current status of muscarinic M1 and M4 receptors as drug targets for neurodegenerative diseases
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Glucagon-like receptor 1 agonists and DPP-4 inhibitors: Anti-diabetic drugs with anti-stroke potential
Fulltext Access 25 Pages 2018
Histamine-deficient mice do not respond to the antidepressant-like effects of oleoylethanolamide
Fulltext Access 25 Pages 2018
Pharmacological activation of mGlu4 and mGlu7 receptors, by LSP2-9166, reduces ethanol consumption and relapse in rat
Fulltext Access 25 Pages 2018
Fingolimod anti-inflammatory and neuroprotective effects modulation of RAGE axis in multiple sclerosis patients
Fulltext Access 25 Pages 2018
P2X7 purinergic receptors participate in the expression and extinction processes of contextual fear conditioning memory in mice
Fulltext Access 25 Pages 2018
In vitro inhibitory properties of sesquiterpenes from Chloranthus serratus on cell motility via down-regulation of LIMK1 activation in human breast cancer
Fulltext Access 25 Pages 2018
Urtica dioica L. leaf extract modulates blood pressure and oxidative stress in spontaneously hypertensive rats
Fulltext Access 25 Pages 2018
The potential of three different PCR-related approaches for the authentication of mixtures of herbal substances and finished herbal medicinal products
Fulltext Access 25 Pages 2018
Phytochemical profile of Orthosiphon aristatus extracts after storage: Rosmarinic acid and other caffeic acid derivatives
Fulltext Access 25 Pages 2018
The Participant Recruitment Outcomes (PRO) study: Exploring contemporary perspectives of telehealth trial non-participation through insights from patients, clinicians, study investigators, and study staff
Fulltext Access 25 Pages 2018
A virus-like particle vaccine protects mice against coxsackievirus A10 lethal infection
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Veratrum nigrum inhibits the estrogenic activity of salvia miltiorrhiza bunge in vivo and in vitro
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4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol is a potential agent for gout therapy as a dual inhibitor of XOD and NLRP3
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Parthenolide reduces metastasis by inhibition of vimentin expression and induces apoptosis by suppression elongation factor α − 1 expression
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Protective role of β-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis
Fulltext Access 25 Pages 2018
Can we increase the speed and efficacy of antidepressant treatments? Part II. Glutamatergic and RNA interference strategies
Fulltext Access 26 Pages 2018
Labrasol® and Salts of Medium-Chain Fatty Acids Can Be Combined in Low Concentrations to Increase the Permeability of a Macromolecule Marker Across Isolated Rat Intestinal Mucosae
Fulltext Access 26 Pages 2018
Using Computational Fluid Dynamics to Compare Shear Rate and Turbulence in the TIM-Automated Gastric Compartment With USP Apparatus II
Fulltext Access 26 Pages 2018
ISG'ylation increases stability of numerous proteins including Stat1, which prevents premature termination of immune response in LPS-stimulated microglia
Fulltext Access 26 Pages 2018
Involvement of neuronal and glial activities in control of the extracellular d-serine concentrations by the AMPA glutamate receptor in the mouse medial prefrontal cortex
Fulltext Access 26 Pages 2018
Dual effects of insect nAChR chaperone RIC-3 on hybrid receptor: Promoting assembly on endoplasmic reticulum but suppressing transport to plasma membrane on Xenopus oocytes
Fulltext Access 26 Pages 2018
Nanomedicine as a potential approach to empower the new strategies for the treatment of preeclampsia
Fulltext Access 26 Pages 2018
Structural basis for selective inhibition of antibacterial target MraY, a membrane-bound enzyme involved in peptidoglycan synthesis
Fulltext Access 26 Pages 2018
Supermolecular drug challenge to overcome drug resistance in cancer cells
Fulltext Access 26 Pages 2018
Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1
Fulltext Access 26 Pages 2018
Dragon's Blood exerts cardio-protection against myocardial injury through PI3K-AKT-mTOR signaling pathway in acute myocardial infarction mice model
Fulltext Access 26 Pages 2018
Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells
Fulltext Access 26 Pages 2018
MicroRNA-17 impairs glucose metabolism in insulin-resistant skeletal muscle via repressing glucose transporter 4 expression
Fulltext Access 26 Pages 2018
The association between inflammatory markers (iNOS, HO-1, IL-33, MIP-1β) and depression with and without posttraumatic stress disorder
Fulltext Access 26 Pages 2018
Cyclophosphamide-modified murine peritoneal macrophages induce CD4+ T contrasuppressor cells that protect contact sensitivity T effector cells from suppression
Fulltext Access 26 Pages 2018
Involvement of α-methylene-γ- and δ-lactones in the suppression of multidrug resistance in MCF-7 cells
Fulltext Access 26 Pages 2018
Casticin inhibits PDGF-induced proliferation and migration of airway smooth muscle cells
Fulltext Access 26 Pages 2018
Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica
Fulltext Access 26 Pages 2018
Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior
Fulltext Access 26 Pages 2018
Schisandrol B promotes liver regeneration after partial hepatectomy in mice
Fulltext Access 26 Pages 2018
EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes
Fulltext Access 26 Pages 2018
Fluorinated phenmetrazine “legal highs” act as substrates for high-affinity monoamine transporters of the SLC6 family
Fulltext Access 26 Pages 2018
Melatonin promotes neuroprotection of induced pluripotent stem cells-derived neural stem cells subjected to H2O2-induced injury in vitro
Fulltext Access 26 Pages 2018
Anti-IL-12/IL-23p40 antibody ameliorates dermatitis and skin barrier dysfunction in mice with imiquimod-induced psoriasis-like dermatitis
Fulltext Access 26 Pages 2018
Mirabegron, a β3-adrenoceptor agonist reduced platelet aggregation through cyclic adenosine monophosphate accumulation
Fulltext Access 26 Pages 2018
Regulation and trafficking of muscarinic acetylcholine receptors
Fulltext Access 26 Pages 2018
Factors affecting the selection of an inhaler device for COPD and the ideal device for different patient profiles. Results of EPOCA Delphi consensus
Fulltext Access 26 Pages 2018
Chloride cotransporter KCC2 is essential for GABAergic inhibition in the SCN
Fulltext Access 26 Pages 2018
Interplay between 5-HT2C and 5-HT1A receptors in the dorsal periaqueductal gray in the modulation of fear-induced antinociception in mice
Fulltext Access 26 Pages 2018
The role of STAG2 in bladder cancer
Fulltext Access 26 Pages 2018
In Vivo Transgene Expression in the Pancreas by the Intraductal Injection of Naked Plasmid DNA
Fulltext Access 26 Pages 2018
Regulatory effect of nicotine on the differentiation of Th1, Th2 and Th17 lymphocyte subsets in patients with rheumatoid arthritis
Fulltext Access 26 Pages 2018
Beta2-adrenergic signaling affects the phenotype of human cardiac progenitor cells through EMT modulation
Fulltext Access 26 Pages 2018
Jaboticaba peel extract decrease autophagy in white adipose tissue and prevents metabolic disorders in mice fed with a high-fat diet
Fulltext Access 26 Pages 2018
Zinc supplementation reduces inflammation in ulcerative colitis patients by downregulating gene expression of Zn metalloproteins
Fulltext Access 26 Pages 2018
Comparison of fluticasone/formoterol with budesonide/formoterol pMDI in adults with moderate to severe persistent asthma: Results from a 12-week randomized controlled trial
Fulltext Access 26 Pages 2018
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