Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption Fulltext Access 9 Pages 2018
Differential regulation of tefluthrin and telmisartan on the gating charges of INa activation and inactivation as well as on resurgent and persistent INa in a pituitary cell line (GH3) Fulltext Access 9 Pages 2018
Metabolomics profiling of steatosis progression in HepaRG® cells using sodium valproate Fulltext Access 9 Pages 2018
Polycyclic aromatic hydrocarbons (PAHs) skin permeation rates change with simultaneous exposures to solar ultraviolet radiation (UV-S) Fulltext Access 9 Pages 2018
The urinary metabolites of DINCH® have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ Fulltext Access 9 Pages 2018
Benzo[a]pyrene activates an AhR/Src/ERK axis that contributes to CYP1A1 induction and stable DNA adducts formation in lung cells Fulltext Access 9 Pages 2018
Synergistic action of the nephrotoxic mycotoxins ochratoxin A and citrinin at nanomolar concentrations in human proximal tubule-derived cells Fulltext Access 9 Pages 2018
An in vitro cytotoxicities comparison of 16 priority polycyclic aromatic hydrocarbons in human pulmonary alveolar epithelial cells HPAEpiC Fulltext Access 9 Pages 2018
Bioscavenger is effective as a delayed therapeutic intervention following percutaneous VX poisoning in the guinea-pig Fulltext Access 9 Pages 2018
Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling Fulltext Access 9 Pages 2018
Suspect and untargeted screening of bisphenol S metabolites produced by in vitro human liver metabolism Fulltext Access 9 Pages 2018
ATF3 is positively involved in particulate matter-induced airway inflammation in vitro and in vivo Fulltext Access 9 Pages 2018
Nickel ions bind to HSP90β and enhance HIF-1α-mediated IL-8 expression Fulltext Access 9 Pages 2018
Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[a]pyrene and expression of this enzyme in rats Fulltext Access 9 Pages 2018
Effects of diesel exhaust-derived secondary organic aerosol (SOA) on oocytes: Potential risks to meiotic maturation Fulltext Access 9 Pages 2018
Acute effect of bisphenol A: Signaling pathways on calcium influx in immature rat testes Fulltext Access 9 Pages 2018
Detection of lindane and 7,12-dimethylbenz[a]anthracene toxicity at low concentrations in a three-dimensional ovarian follicle culture system Fulltext Access 9 Pages 2018
Bisphenol A modulates inflammation and proliferation pathway in human endometrial stromal cells by inducing oxidative stress Fulltext Access 9 Pages 2018
Estrous cycle-dependent modulation of in vivo microvascular dysfunction after nanomaterial inhalation Fulltext Access 9 Pages 2018
Roles of the KEAP1-NRF2 system in mammalian skin exposed to UV radiation Fulltext Access 9 Pages 2018
Stabilization of the hypoxia-inducible transcription Factor-1 alpha (HIF-1α) in thiamine deficiency is mediated by pyruvate accumulation Fulltext Access 9 Pages 2018
The vanillin derivative 6-bromine-5-hydroxy-4-methoxybenzaldehyde induces aberrant mitotic progression and enhances radio-sensitivity accompanying suppression the expression of PLK1 in esophageal squamous cell carcinoma Fulltext Access 9 Pages 2018
Effects of continuous bisphenol A exposure from early gestation on 90â¯day old rat testes function and sperm molecular profiles: A CLARITY-BPA consortium study Fulltext Access 9 Pages 2018
The antipsychotics sulpiride induces fatty liver in rats via phosphorylation of insulin receptor substrate-1 at Serine 307-mediated adipose tissue insulin resistance Fulltext Access 9 Pages 2018
Pb2Â + modulates ryanodine receptors from the endoplasmic reticulum in rat brain Fulltext Access 9 Pages 2018
EGR1 is essential for deoxynivalenol-induced G2/M cell cycle arrest in HepG2 cells via the ATF3ÎZip2a/2b-EGR1-p21 pathway Fulltext Access 9 Pages 2018
Optimizing the cutoff for the identification of skin sensitizers by the HaCaSens assay: Introducing an ROC-analysis-based cutoff approach Fulltext Access 9 Pages 2018
Role of NADPH oxidase in cooperative reactive oxygen species generation in dopaminergic neurons induced by combined treatment with dieldrin and lindane Fulltext Access 9 Pages 2018
Transcriptional profiling of irritant contact dermatitis (ICD) in a mouse model identifies specific patterns of gene expression and immune-regulation Fulltext Access 9 Pages 2018
Integration of sperm DNA damage assessment into OECD test guidelines for genotoxicity testing using the MutaMouse model Fulltext Access 9 Pages 2018
ZnSO4 rescued vimentin from collapse in DBP-exposed Sertoli cells by attenuating ER stress and apoptosis Fulltext Access 10 Pages 2018
Prelimbic NMDA receptors stimulation mimics the attenuating effects of clozapine on the auditory electrophysiological rebound induced by ketamine withdrawal Fulltext Access 10 Pages 2018
MIM1, the Mcl-1 - specific BH3 mimetic induces apoptosis in human U87MG glioblastoma cells Fulltext Access 10 Pages 2018
Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine Fulltext Access 10 Pages 2018
ST elevation: Differential diagnosis and caveats. A comprehensive review to help distinguish ST elevation myocardial infarction from nonischemic etiologies of ST elevation Fulltext Access 10 Pages 2018
BENC-511, a novel PI3K inhibitor, suppresses metastasis of non-small cell lung cancer cells by modulating β-catenin/ZEB1 regulatory loop Fulltext Access 10 Pages 2018
Vitamin C exerts novel protective effects against cadmium toxicity in mouse spermatozoa by inducing the dephosphorylation of dihydrolipoamide dehydrogenase Fulltext Access 10 Pages 2018
Toxicologic/transport properties of NCS-382, a γ-hydroxybutyrate (GHB) receptor ligand, in neuronal and epithelial cells: Therapeutic implications for SSADH deficiency, a GABA metabolic disorder Fulltext Access 10 Pages 2018
A retrospective analysis of adverse effects of an in vivo fluoroquinolone antibiotic enrofloxacin treatment on oocyte quality in the common marmoset Fulltext Access 10 Pages 2018
Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice Fulltext Access 10 Pages 2018
Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations Fulltext Access 10 Pages 2018
Exposure to a combination of formaldehyde and DINP aggravated asthma-like pathology through oxidative stress and NF-κB activation Fulltext Access 10 Pages 2018
Liver lobe and strain differences in the activity of murine cytochrome P450 enzymes Fulltext Access 10 Pages 2018
Mutagenic and genotoxic potential of pure Cylindrospermopsin by a battery of in vitro tests Fulltext Access 10 Pages 2018
Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes Fulltext Access 10 Pages 2018
Role of glutathione S-transferases in detoxification of a polycyclic aromatic hydrocarbon, methylcholanthrene Fulltext Access 10 Pages 2018
MeHg affects the activation of FAK, Src, Rac1 and Cdc42, critical proteins for cell movement in PDGF-stimulated SH-SY5Y neuroblastoma cells Fulltext Access 10 Pages 2018
MiR-301b-3p/3584-5p enhances low-dose mono-n-butyl phthalate (MBP)-induced proliferation by targeting Rasd1 in Sertoli cells Fulltext Access 10 Pages 2018
Toxicogenomic responses to zearalenone in Caenorhabditis elegans reveal possible molecular mechanisms of reproductive toxicity Fulltext Access 10 Pages 2018
Methylmercury exposure causes a persistent inhibition of myogenin expression and C2C12 myoblast differentiation Fulltext Access 10 Pages 2018
Residential proximity to green spaces and breast cancer risk: The multicase-control study in Spain (MCC-Spain) Fulltext Access 10 Pages 2018
Diethylstilbestrol (DES) induces autophagy in thymocytes by regulating Beclin-1 expression through epigenetic modulation Fulltext Access 10 Pages 2018
NaHS restores mitochondrial function and inhibits autophagy by activating the PI3K/Akt/mTOR signalling pathway to improve functional recovery after traumatic brain injury Fulltext Access 10 Pages 2018
Enterococcus spp. in Ragusano PDO and Pecorino Siciliano cheese types: A snapshot of their antibiotic resistance distribution Fulltext Access 10 Pages 2018
Diallyl sulfide protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice Fulltext Access 10 Pages 2018
Protective effects of (-)-epicatechin and the colonic metabolite 3,4-dihydroxyphenylacetic acid against glucotoxicity-induced insulin signalling blockade and altered glucose uptake and production in renal tubular NRK-52E cells Fulltext Access 10 Pages 2018
Proteomic analysis of 2-monochloropropanediol (2-MCPD) and 2-MCPD dipalmitate toxicity in rat kidney and liver in a 28-days study Fulltext Access 10 Pages 2018
High resolution metabolomics to determines the risk associated with bisphenol A exposure in humans Fulltext Access 10 Pages 2018
Kaempferol protects against gamma radiation-induced mortality and damage via inhibiting oxidative stress and modulating apoptotic molecules in vivo and vitro Fulltext Access 10 Pages 2018
Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells Fulltext Access 10 Pages 2018
Unraveling CYP2E1 haplotypes in alcoholics from Central Brazil: A comparative study with 1000 genomes population Fulltext Access 10 Pages 2018
Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs Fulltext Access 10 Pages 2018
New 1,3-benzodioxole derivatives: Synthesis, evaluation of in vitro schistosomicidal activity and ultrastructural analysis Fulltext Access 10 Pages 2018
Selenium deficiency aggravates T-2 toxin-induced injury of primary neonatal rat cardiomyocytes through ER stress Fulltext Access 10 Pages 2018
Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin αvβ3 and IGF-1R Fulltext Access 10 Pages 2018
RNA interference against stromal interacting molecule-1 (STIM1) ameliorates ethanol-induced hepatotoxicity Fulltext Access 10 Pages 2018
Mesalazine, an osteopontin inhibitor: The potential prophylactic and remedial roles in induced liver fibrosis in rats Fulltext Access 10 Pages 2018
Methyl ferulic acid attenuates ethanol-induced hepatic steatosis by regulating AMPK and FoxO1 Pathways in Rats and L-02 cells Fulltext Access 10 Pages 2018
Proapoptic and immunotoxic effects of sulfur-fumigated polysaccharides from Smilax glabra Roxb. in RAW264.7â¯cells Fulltext Access 10 Pages 2018
Cirsimarin, a flavone glucoside from the aerial part of Cirsium japonicum var. ussuriense (Regel) Kitam. ex Ohwi, suppresses the JAK/STAT and IRF-3 signaling pathway in LPS-stimulated RAW 264.7 macrophages Fulltext Access 10 Pages 2018
Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice Fulltext Access 10 Pages 2018
Development, qualification, validation and application of the Ames test using a VITROCELL® VC10® smoke exposure system Fulltext Access 10 Pages 2018
Bioactive profiling and therapeutic potential of mushroom (Pleurotus tuberregium) extract on Wistar albino rats (Ratus norvegicus) exposed to arsenic and chromium toxicity Fulltext Access 10 Pages 2018
New research highlights: Impact of chronic ingestion of white kidney beans (Phaseolus vulgaris L. var. Beldia) on small-intestinal disaccharidase activity in Wistar rats Fulltext Access 10 Pages 2018
Evaluation of acute and sublethal effects of chloroquine (C18H26CIN3) on certain enzymological and histopathological biomarker responses of a freshwater fish Cyprinus carpio Fulltext Access 10 Pages 2018
Piperlongumine decreases cell proliferation and the expression of cell cycle-associated proteins by inhibiting Akt pathway in human lung cancer cells Fulltext Access 10 Pages 2018
Ahr and Cyp1a2 genotypes both affect susceptibility to motor deficits following gestational and lactational exposure to polychlorinated biphenyls Fulltext Access 10 Pages 2018
Arsenic impairs insulin signaling in differentiated neuroblastoma SH-SY5Y cells Fulltext Access 10 Pages 2018
Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity Fulltext Access 10 Pages 2018
Ag-NPs induce apoptosis, mitochondrial damages and MT3/OSGIN2 expression changes in an in vitro model of human dental-pulp-stem-cells-derived neurons Fulltext Access 10 Pages 2018
Identification of nanomaterials: A validation report of two laboratories using analytical ultracentrifugation with fixed and ramped speed options Fulltext Access 10 Pages 2018
Co-exposure of imidacloprid and nanoparticle Ag or CeO2 to Cucurbita pepo (zucchini): Contaminant bioaccumulation and translocation Fulltext Access 10 Pages 2018
Multiple identification of most important waterborne protozoa in surface water used for irrigation purposes by 18S rRNA amplicon-based metagenomics Fulltext Access 10 Pages 2018
Conversion between noise exposure indicators Leq24h, LDay, LEvening, LNight, Ldn and Lden: Principles and practical guidance Fulltext Access 10 Pages 2018
Buccal micronucleus cytome assay in primary school children: A descriptive analysis of the MAPEC_LIFE multicenter cohort study Fulltext Access 10 Pages 2018
Di-N-octylphthalate acts as a proliferative agent in murine cell hepatocytes by regulating the levels of TGF-β and pro-apoptotic proteins Fulltext Access 10 Pages 2018
Molecular mechanism of anti-cancerous potential of Morin extracted from mulberry in Hela cells Fulltext Access 10 Pages 2018
Association of exposure to manganese and iron with relaxation rates R1 and R2*- magnetic resonance imaging results from the WELDOX II study Fulltext Access 10 Pages 2018
Apoptosis induction by Pleurotus sajor-caju (Fr.) Singer extracts on colorectal cancer cell lines Fulltext Access 10 Pages 2018
Gypenosides protect retinal pigment epithelium cells from oxidative stress Fulltext Access 10 Pages 2018
RIFM fragrance ingredient safety assessment 2-Benzylheptanol, CAS Registry Number 92368-90-6 Fulltext Access 10 Pages 2018
RIFM fragrance ingredient safety assessment, benzyl formate, CAS Registry Number 104-57-4 Fulltext Access 10 Pages 2018
RIFM fragrance ingredient safety assessment, phenethyl tiglate, CAS Registry Number 55719-85-2 Fulltext Access 10 Pages 2018
RIFM fragrance ingredient safety assessment diethyl succinate, CAS Registry Number 123-25-1 Fulltext Access 10 Pages 2018
RIFM fragrance ingredient safety assessment 2,4-dimethylbenzyl acetate, CAS Registry Number 62346-96-7 Fulltext Access 10 Pages 2018
RIFM fragrance ingredient safety assessment, Amylcyclohexyl acetate (mixed isomers), CAS Registry Number 67874-72-0 Fulltext Access 10 Pages 2018
Vitamin K2, a menaquinone present in dairy products targets castration-resistant prostate cancer cell-line by activating apoptosis signaling Fulltext Access 10 Pages 2018
Acute and subchronic toxicities of the ethanol and hot-water extracts from Chinese sumac (Rhus chinensis Mill.) fruits by oral administration in rats Fulltext Access 10 Pages 2018