Neighbourhood walkability and incidence of hypertension: Findings from the study of 429,334 UK Biobank participants Fulltext Access 11 Pages 2018
Necroptosis in 3-chloro-1, 2-propanediol (3-MCPD)-dipalmitate-induced acute kidney injury in vivo and its repression by miR-223-3p Fulltext Access 11 Pages 2018
Is omphalocele a non-specific malformation in New Zealand White rabbits? Fulltext Access 11 Pages 2018
An Adverse Outcome Pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events Fulltext Access 11 Pages 2018
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro Fulltext Access 11 Pages 2018
Arsenic exposure during embryonic development alters the expression of the long noncoding RNA growth arrest specific-5 (Gas5) in a sex-dependent manner Fulltext Access 11 Pages 2018
Neuroprotective effect of morin on lead acetate- induced apoptosis by preventing cytochrome c translocation via regulation of Bax/Bcl-2 ratio Fulltext Access 11 Pages 2018
The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice Fulltext Access 11 Pages 2018
Effect of neonatal hyperoxia followed by concentrated ambient ultrafine particle exposure on cumulative learning in C57Bl/6J mice Fulltext Access 11 Pages 2018
Human iPSC-derived neuronal models for in vitro neurotoxicity assessment Fulltext Access 11 Pages 2018
Effects of the adsorption of NOM model molecules on the aggregation of TiO2 nanoparticles in aqueous suspensions Fulltext Access 11 Pages 2018
CaMKâ ¡ mediates cadmium induced apoptosis in rat primary osteoblasts through MAPK activation and endoplasmic reticulum stress Fulltext Access 11 Pages 2018
New iridoids from Verbascum nobile and their effect on lectin-induced T cell activation and proliferation Fulltext Access 11 Pages 2018
Essential oils of culinary herbs and spices display agonist and antagonist activities at human aryl hydrocarbon receptor AhR Fulltext Access 11 Pages 2018
Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro Fulltext Access 11 Pages 2018
Chemical findings and in vitro biological studies to uphold the use of Ficus exasperata Vahl leaf and stem bark Fulltext Access 11 Pages 2018
Hibiscus sabdariffa anthocyanins-rich extract: Chemical stability, in vitro antioxidant and antiproliferative activities Fulltext Access 11 Pages 2018
Risk assessment of aflatoxin B1 exposure from maize and peanut consumption in Indonesia using the margin of exposure and liver cancer risk estimation approaches Fulltext Access 11 Pages 2018
RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT phenylethyl 2-methylbutyrate, CAS Registry Number 24817-51-4 Fulltext Access 11 Pages 2018
RIFM fragrance ingredient safety assessment phenethyl isovalerate, CAS Registry Number 140-26-1 Fulltext Access 11 Pages 2018
RIFM fragrance ingredient safety assessment benzyl 2,2-dimethylpropanoate, CAS Registry Number 2094-69-1 Fulltext Access 11 Pages 2018
RIFM fragrance ingredient safety assessment, l-menthyl lactate, CAS Registry Number 59259-38-0 Fulltext Access 11 Pages 2018
N6-methyladenosine mediates the cellular proliferation and apoptosis via microRNAs in arsenite-transformed cells Fulltext Access 11 Pages 2018
Accurate measurement of main aerosol constituents from heated tobacco products (HTPs): Implications for a fundamentally different aerosol Fulltext Access 11 Pages 2018
Emodin-induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2 Fulltext Access 11 Pages 2018
mGluR5 upregulation and the effects of repeated methamphetamine administration and withdrawal on the rewarding efficacy of ketamine and social interaction Fulltext Access 11 Pages 2018
Safety of the Bacillus thuringiensis-derived Cry1A.105 protein: Evidence that domain exchange preserves mode of action and safety Fulltext Access 11 Pages 2018
RIFM fragrance ingredient safety assessment, Hexyl acetate, CAS Registry Number 142-92-7 Fulltext Access 11 Pages 2018
Toxic equivalency factors (TEFs) after acute oral exposure of azaspiracid 1, â2 and â3 in mice Fulltext Access 11 Pages 2018
6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells Fulltext Access 11 Pages 2018
The synthetic cannabinoid XLR-11 induces in vitro nephrotoxicity by impairment of endocannabinoid-mediated regulation of mitochondrial function homeostasis and triggering of apoptosis Fulltext Access 11 Pages 2018
Alterations in the nigrostriatal dopamine system after acute systemic PhIP exposure Fulltext Access 11 Pages 2018
XPF plays an indispensable role in relieving silver nanoparticle induced DNA damage stress in human cells Fulltext Access 11 Pages 2018
The excitotoxity of NMDA receptor NR2D subtype mediates human fetal lung fibroblasts proliferation and collagen production Fulltext Access 11 Pages 2018
Lipidomic signature of serum from the rats exposed to alcohol for one year Fulltext Access 11 Pages 2018
Single ingestion of di-(2-propylheptyl) phthalate (DPHP) by male volunteers: DPHP in blood and its metabolites in blood and urine Fulltext Access 11 Pages 2018
Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction Fulltext Access 11 Pages 2018
Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Cav3.2 in mice Fulltext Access 11 Pages 2018
Assessment of metal sensitizer potency with the reconstructed human epidermis IL-18 assay Fulltext Access 11 Pages 2018
Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells Fulltext Access 11 Pages 2018
The expressional disorder of the renal RAS mediates nephrotic syndrome of male rat offspring induced by prenatal ethanol exposure Fulltext Access 11 Pages 2018
SN56 neuronal cell death after 24â¯h and 14â¯days chlorpyrifos exposure through glutamate transmission dysfunction, increase of GSK-3β enzyme, β-amyloid and tau protein levels Fulltext Access 11 Pages 2018
Neurotoxicity assessment of oleic acid-coated iron oxide nanoparticles in SH-SY5Y cells Fulltext Access 11 Pages 2018
Whole genome mRNA transcriptomics analysis reveals different modes of action of the diarrheic shellfish poisons okadaic acid and dinophysis toxin-1 versus azaspiracid-1 in Caco-2 cells Fulltext Access 11 Pages 2018
Toxicogenomics of the flame retardant tris (2-butoxyethyl) phosphate in HepG2 cells using RNA-seq Fulltext Access 11 Pages 2018
In vitro characterization of zebrafish (Danio rerio) organic anion transporters Oat2a-e Fulltext Access 11 Pages 2018
Short- and long-term gene expression profiles induced by inhaled TiO2 nanostructured aerosol in rat lung Fulltext Access 11 Pages 2018
Inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation Fulltext Access 11 Pages 2018
Expression and function of TLR4- induced B1R bradykinin receptor on cardiac fibroblasts Fulltext Access 11 Pages 2018
Preclinical evaluation of the mono-PEGylated recombinant human interleukin-11 in cynomolgus monkeys Fulltext Access 11 Pages 2018
Temporal cytokine and lymphoid responses to an inhaled TLR7 antedrug agonist in the cynomolgus monkey demonstrates potential safety and tolerability of this approach Fulltext Access 11 Pages 2018
Lateral flow immunoassay and enzyme linked immunosorbent assay as effective immunomethods for the detection of synthetic cannabinoid JWH-200 based on the newly synthesized hapten Fulltext Access 11 Pages 2018
Evaluation of the systemic toxicity and mutagenicity of OLIGOPIN®, procyanidolic oligomers (OPC) extracted from French Maritime Pine Bark extract Fulltext Access 11 Pages 2018
Neuro- and nephroprotective effect of grape seed proanthocyanidin extract against carboplatin and thalidomide through modulation of inflammation, tumor suppressor protein p53, neurotransmitters, oxidative stress and histology Fulltext Access 11 Pages 2018
Tumor-promoting and pro-angiogenic effects of roxarsone via VEGFR2/PLCγ/PKC signaling Fulltext Access 11 Pages 2018
Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway Fulltext Access 11 Pages 2018
Serum derived from ulcerative colitis mouse changes the metabolism of the fluorescent substrate by P450 depending on the degree of disease progression Fulltext Access 11 Pages 2018
Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1 Fulltext Access 11 Pages 2018
Sensitivity of Arbor Acres broilers and chemoprevention of aflatoxin B1-induced liver injury by curcumin, a natural potent inducer of phase-II enzymes and Nrf2 Fulltext Access 11 Pages 2018
Expression of genes related to metal metabolism in the freshwater fish Hyphessobrycon luetkenii living in a historically contaminated area associated with copper mining Fulltext Access 11 Pages 2018
Effects of polysaccharides from Inonotus obliquus and its chromium (III) complex on advanced glycation end-products formation, α-amylase, α-glucosidase activity and H2O2-induced oxidative damage in hepatic L02â¯cells Fulltext Access 11 Pages 2018
Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest Fulltext Access 11 Pages 2018
Evidence of similar protective effects afforded by white tea and its active component 'EGCG' on oxidative-stress mediated hepatic dysfunction during benzo(a)pyrene induced toxicity Fulltext Access 11 Pages 2018
Purification and identification of an actinomycin D analogue from actinomycetes associated with Ganoderma applanatum via magnetic molecularly imprinted polymers and tandem mass spectrometry Fulltext Access 11 Pages 2018
Metabolism-dependent cytotoxicity of citrinin and ochratoxin A alone and in combination as assessed adopting integrated discrete multiple organ co-culture (IdMOC) Fulltext Access 12 Pages 2018
The tamoxifen derivative ridaifen-B is a high affinity selective CB2 receptor inverse agonist exhibiting anti-inflammatory and anti-osteoclastogenic effects Fulltext Access 12 Pages 2018
Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods Fulltext Access 12 Pages 2018
Brain damage and neurological symptoms induced by T-2 toxin in rat brain Fulltext Access 12 Pages 2018
Lung fibroblasts may play an important role in clearing apoptotic bodies of bronchial epithelial cells generated by exposure to PHMG-P-containing solution Fulltext Access 12 Pages 2018
Involvement of estrogen receptor α in pro-pruritic and pro-inflammatory responses in a mouse model of allergic dermatitis Fulltext Access 12 Pages 2018
Myeloid differentiation protein 2 induced retinal ischemia reperfusion injury via upregulation of ROS through a TLR4-NOX4 pathway Fulltext Access 12 Pages 2018
Hepatorenal protective effects of medicinal herbs in An-Gong-Niu-Huang Wan (AGNH) against cinnabar- and realgar-induced oxidative stress and inflammatory damage in mice Fulltext Access 12 Pages 2018
Safety evaluation of the temporary consolidant based on a zebrafish embryo model Fulltext Access 12 Pages 2018
Reprint of “CON4EI: Bovine Corneal Opacity and Permeability (BCOP) test for hazard identification and labelling of eye irritating chemicals” Fulltext Access 12 Pages 2018
Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome Fulltext Access 12 Pages 2018
The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells Fulltext Access 12 Pages 2018
Time-Integrative Passive sampling combined with TOxicity Profiling (TIPTOP): an effect-based strategy for cost-effective chemical water quality assessment Fulltext Access 12 Pages 2018
Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces hepatic steatosis and endoplasmic reticulum stress by inducing nuclear factor erythroid-derived 2-related factor 2 nuclear translocation Fulltext Access 12 Pages 2018
Summer savory (Satureja hortensis L.) extract: Phytochemical profile and modulation of cisplatin-induced liver, renal and testicular toxicity Fulltext Access 12 Pages 2018
Full Length ArticleAn in vitro cytotoxic approach to assess the toxicity of heavy metals and their binary mixtures on hippocampal HT-22 cell line Fulltext Access 12 Pages 2018
Decanoic acid suppresses proliferation and invasiveness of human trophoblast cells by disrupting mitochondrial function Fulltext Access 12 Pages 2018
Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cells DU145 Fulltext Access 12 Pages 2018
In vitro antioxidant and antihypertensive compounds from camu-camu (Myrciaria dubia McVaugh, Myrtaceae) seed coat: A multivariate structure-activity study Fulltext Access 12 Pages 2018
Inï¬uence of formulation of ZnO nanoblokes containing metallic ions dopants on their cytotoxicity and protective factors: An in vitro study on human skin cells exposed to UVA radiation Fulltext Access 12 Pages 2018
Nevada desert dust with heavy metals suppresses IgM antibody production Fulltext Access 12 Pages 2018
CYP1A gene expression as a basic factor for fipronil toxicity in Caspian kutum fish Fulltext Access 12 Pages 2018
Isolation and identification of new chemical constituents from Chinese chive (Allium tuberosum) and toxicological evaluation of raw and cooked Chinese chive Fulltext Access 12 Pages 2018
The second generation tyrosine kinase inhibitor dasatinib induced eryptosis in human erythrocytes-An in vitro study Fulltext Access 12 Pages 2018
Probing flecainide block of INa using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers Fulltext Access 12 Pages 2018
Multidimensional chemobehavior analysis of flavonoids and neuroactive compounds in zebrafish Fulltext Access 12 Pages 2018
nAChRs-ERK1/2-Egr-1 signaling participates in the developmental toxicity of nicotine by epigenetically down-regulating placental 11β-HSD2 Fulltext Access 12 Pages 2018
Isolated mangiferin and naringenin exert antidiabetic effect via PPARγ/GLUT4 dual agonistic action with strong metabolic regulation Fulltext Access 12 Pages 2018
Preclinical safety evaluation of the ethanolic extract from guavira fruits (Campomanesia pubescens (D.C.) O. BERG) in experimental models of acute and short-term toxicity in rats Fulltext Access 12 Pages 2018
Indole-3-carbinol induces apoptosis in human hepatocellular carcinoma Huh-7â¯cells Fulltext Access 12 Pages 2018